Insect Moulting Hormones: The Synthesis of Ecdysone Analogues From a Bile Acid

1976 ◽  
Vol 29 (8) ◽  
pp. 1815 ◽  
Author(s):  
J Kinnear ◽  
M Martin ◽  
DS Horn ◽  
E Middleton ◽  
J Wilkie ◽  
...  
Keyword(s):  
Biological Activity ◽  
Bile Acid ◽  
Chenodeoxycholic Acid ◽  
Moulting Hormones ◽  
General Synthesis

A new general synthesis of 2-deoxyecdysone analogues starting from the bile acid, chenodeoxycholic acid, has been developed and used to prepare a number of ecdysones for structure-biological activity studies.

scholarly journals Bile Acid Synthesis Disorders in Japan: Long-Term Outcome and Chenodeoxycholic Acid Treatment

2021 ◽  
Author(s):  
Akihiko Kimura ◽  
Tatsuki Mizuochi ◽  
Hajime Takei ◽  
Akira Ohtake ◽  
Jun Mori ◽  
...  
Keyword(s):  
Bile Acid ◽  
Chenodeoxycholic Acid ◽  
Acid Treatment ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes

Life Sciences ◽  
2016 ◽  
Vol 156 ◽  
pp. 47-56 ◽  
Author(s):  
Regina Krattinger ◽  
Adrian Boström ◽  
Serene M.L. Lee ◽  
Wolfgang E. Thasler ◽  
Helgi B. Schiöth ◽  
...  
Keyword(s):  
Bile Acid ◽  
Drug Metabolism ◽  
Chenodeoxycholic Acid ◽  
Human Hepatocytes

Differential intestinal deconjugation of taurine and glycine bile acid N-acyl amidates in rats

1992 ◽  
Vol 262 (2) ◽  
pp. G351-G358
Author(s):  
R. Zhang ◽  
S. Barnes ◽  
R. B. Diasio
Keyword(s):  
High Performance Liquid Chromatography ◽  
Small Intestine ◽  
Liquid Chromatography ◽  
Bile Acid ◽  
Chenodeoxycholic Acid ◽  
High Performance ◽  
Biliary Fistula ◽  
The Difference ◽  
The Stability ◽  
Rat Bile

Mechanisms responsible for the difference in the relative amounts of taurine- and glycine-conjugated bile acid N-acyl amidates (Tau/Gly ratio) are not fully understood. In the present study, the stability of taurine- and glycine-conjugated bile acid N-acyl amidates during intestinal transit and absorption was examined to investigate the contribution of intestinal deconjugation to the Tau/Gly ratio in rat bile. Radiolabeled chenodeoxycholic acid (CDC) and its N-acyl amidates with glycine (CDC-Gly) or taurine (CDC-Tau) were introduced into the lumen of the upper small intestine in the biliary fistula rats, and radioactive metabolites in bile, blood, urine, and tissues were identified and quantitated by high-performance liquid chromatography. Results indicated that 1) extensive deconjugation of CDC-Gly occurs during intestinal absorption; 2) CDC-Tau is recovered in bile largely intact; and 3) newly synthesized CDC-Tau and CDC-Gly are formed in a ratio of less than 2:1 after administration of [14C]-CDC. In summary, the present study demonstrates that resistance of taurine-conjugated bile acid N-acyl amidates to hydrolysis in the intestine, rather than a difference in synthesis of taurine- and glycine-conjugated N-acyl amidates in liver, may account for the high Tau/Gly ratio in rat bile.

Development, validation, and application of a single-tube radioimmunoassay for cholic and chenodeoxycholic conjugated bile acids in human serum.

1977 ◽  
Vol 23 (11) ◽  
pp. 2107-2113 ◽  
Author(s):  
A Roda ◽  
E Roda ◽  
R Aldini ◽  
D Festi ◽  
G Mazzella ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Liver Disease ◽  
Bile Acid ◽  
Human Serum ◽  
Chenodeoxycholic Acid ◽  
Serum Samples ◽  
Single Tube ◽  
Glycocholic Acid ◽  
Low Concentrations ◽  
Conjugated Bile Acids

Abstract A single-tube radioimmunoassay for both cholic acid and chenodeoxycholic acid conjugates in serum is based on the use of [1-(14)C]glycocholic acid and [H-3H]glycochenodeoxycholic acid as tracers. The assay was shown to be specific, sensitive, accurate, and precise (CV = 13% at low concentrations, 5.5% at higher concentrations) when used for serum samples from subjects and patients with increased bile acid in the serum because of liver disease, and results correlate well with those by gas chromatography (r = .99).

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