A revision of the structures proposed for the melicope extractives, melicopol and methylmelicopol

1973 ◽  
Vol 26 (11) ◽  
pp. 2459 ◽  
Author(s):  
BS Balgir ◽  
LN Mander ◽  
STK Mander
Keyword(s):  
Methyl Ether ◽  
Partial Methylation ◽  
Ether Derivative

2,4,6-Trihydroxybenzoic acid was converted by partial methylation, formylation, and then reduction into methyl 2-hydroxy-3-hydroxymethyl- 4,6-dimethoxybenzoate (5) which proved different from dimethyldegeranylmelicopol. Methyl 6-geranyloxy-2-hydroxy-3- hydroxymethyl-4-methoxybenzoate (4), its neryl analogue (7), and methyl 4-geranyloxy-2-hydroxy-3-hydroxymethyl-6-methoxybenzoate (21) were prepared similarly but all were different from methylmelicopol. From a re-investigation of earlier work, melicopol and methylmelicopol were assigned new structures, 6?-geranyloxy-2,2?,4?-tri-hydroxy-3?- methoxyacetophenone (31) and its 4?-methyl ether derivative (24), respectively. Dimethyldegeranylmelicopol, 2,6?-dihydroxy-2?,3?,4?- trimethoxyacetophenone (25), was prepared from antiarol (28) and acetoxyacetonitrile.

An Alternative Route to 2-Bromo-Estradiols and 2-Iodo-Estradiols From Estradiol

1987 ◽  
Vol 40 (2) ◽  
pp. 303 ◽  
Author(s):  
DJ Pert ◽  
DD Ridley
Keyword(s):  
Methyl Ether ◽  
Alternative Route ◽  
Reaction Conditions ◽  
Careful Choice ◽  
Ether Derivative ◽  
Trimethylsilyl Derivatives

Through careful choice of reaction conditions, alkylation of estradiol with chloromethyl methyl ether may yield either the 3,17β-bis(methoxymethy1) ether or the 3-methoxymethyl ether derivative. Treatment of either of these protected estradiols with s- butyllithium, then with trimethylsilyl chloride affords, regioselectively, the 2-trimethylsilyl derivatives which can conveniently be converted into 2-bromo-or 2-iodo-estradiol.

METHYLATION OF SUGAR DITHIOACETALS: IV. D-XYLOSE DIETHYL DITHIOACETAL

1962 ◽  
Vol 40 (10) ◽  
pp. 1899-1902 ◽  
Author(s):  
G. G. S. Dutton ◽  
Y. Tanaka
Keyword(s):  
Methyl Iodide ◽  
Methyl Ether ◽  
Silver Oxide ◽  
Partial Methylation ◽  
Tetrahydrofuran Solution

Partial methylation of D-xylose diethyl dithioacetal in tetrahydrofuran with methyl iodide and silver oxide yielded 2-, 3-, and 5-O-methyl-D-xyloses in the ratio of 20:10:1. The poly-O-methylated components were not examined. The 2-O-methyl-D-xylose was identified as the crystalline sugar and the 3-O-methyl ether as the phenylosazone and p-bromophenylosazone. An alternative preparation of the dithioacetal in tetrahydrofuran solution is described.

scholarly journals Molecularly imprinted polymeric coatings for sensitive and selective gravimetric detection of artemether

RSC Advances ◽  
2020 ◽  
Vol 10 (57) ◽  
pp. 34355-34363
Author(s):  
Usman Arshad ◽  
Adnan Mujahid ◽  
Peter Lieberzeit ◽  
Adeel Afzal ◽  
Sadia Zafar Bajwa ◽  
...  
Keyword(s):  
Methyl Ether ◽  
Antimalarial Drugs ◽  
Polymeric Coatings ◽  
Molecularly Imprinted ◽  
Chemical Structures ◽  
Ether Derivative

Chemical structures of the antimalarial drugs: artemisinin, artemether (a methyl ether derivative of artemisinin), and lumefantrine.

THE PHARMACOLOGICAL ACTIONS OF CAPAURINE

1944 ◽  
Vol 22e (3) ◽  
pp. 64-66 ◽  
Author(s):  
A. K. Reynolds ◽  
R. A. Waud
Keyword(s):  
Smooth Muscle ◽  
Methyl Ether ◽  
Plant Family ◽  
Ether Derivative ◽  
Central Origin ◽  
Convulsant Drug

The pharmacological actions of a new alkaloid, capaurine, and its O-methyl ether derivative have been studied. Capaurine was isolated from Corydalis aurea, a member of the plant family Fumariaceae, which is indigenous to Canada.The base produces paralysis in frogs and convulsions in mice and rabbits, both effects being of central origin. The heart is depressed as is the smooth muscle of the intestine and uterus. Capaurine O-methyl ether is a convulsant drug exhibiting actions on the heart and smooth muscle quite similar to those of the alkaloid itself.

A test of the effects of pregnenolone methyl ether on subjective feelings of B-29 crews after a twelve-hour mission.

1955 ◽  
Author(s):  
Saul B. Sells ◽  
John R. Barry ◽  
David K. Trites ◽  
Herman I. Chinn
Keyword(s):  
Methyl Ether

Observations on a Relationship between Steroid Metabolism and the Concentration of Plasma Fibrinogen

1963 ◽  
Vol 10 (02) ◽  
pp. 400-405 ◽  
Author(s):  
B. A Amundson ◽  
L. O Pilgeram
Keyword(s):  
Blood Coagulation ◽  
Methyl Ether ◽  
Broad Spectrum ◽  
Human Subjects ◽  
Plasma Fibrinogen ◽  
Steroid Metabolism ◽  
Specific Site ◽  
Chain Reaction ◽  
Normal Human ◽  
A Chain

SummaryEnovid (5 mg norethynodrel and 0.075 mg ethynylestradiol-3-methyl ether) therapy in young normal human subjects causes an increase in plasma fibrinogen of 32.4% (P >C 0.001). Consideration of this effect together with other effects of Enovid on the activity of specific blood coagulatory factors suggests that the steroids are exerting their effect at a specific site of the blood coagulation and/or fibrinolytic system. The broad spectrum of changes which are induced by the steroids may be attributed to a combination of a chain reaction and feed-back control.

Partial methylation of methyl 4,6-dideoxy-α-D-arabino-hexopyranoside

1977 ◽  
Vol 42 (11) ◽  
pp. 3180-3185 ◽  
Author(s):  
K. Kefurt ◽  
Z. Kefurtová ◽  
V. Ineman ◽  
J. Jarý
Keyword(s):  
Partial Methylation
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