Synthesis of 2,6,7-Trimethoxy-3,4-methylenedioxyphenanthene, a degradation product of ocoteine

1973 ◽  
Vol 26 (9) ◽  
pp. 2035 ◽  
Author(s):  
GY Moltrasio ◽  
D Giacopello ◽  
MJ Vernengo
Keyword(s):  
Degradation Product ◽  
Aporphine Alkaloid ◽  
Pschorr Reaction

The synthesis of 2,6,7-trimethoxy-3,4-methylenedioxyphenanthrene (3) by the application of the Pschorr reaction is reported. The product was identical with that obtained by degradation of the aporphine alkaloid ocoteine (2).

The Different Forms of Antithrombin III in Serum

1977 ◽  
Vol 38 (02) ◽  
pp. 0494-0503 ◽  
Author(s):  
D. S Pepper ◽  
D Banhegyi ◽  
J. D Cash
Keyword(s):  
Molecular Weight ◽  
Affinity Chromatography ◽  
Human Serum ◽  
Degradation Product ◽  
Antithrombin Iii ◽  
Gel Filtration ◽  
Free Form ◽  
Polymeric Form ◽  
At Iii ◽  
Human Thrombin

SummaryAntithrombin III (AT III) complexes were isolated from human serum by affinity chromatography and gel filtration. In the first step of the preparation, using heparin-agarose chromatography, we observed that the complexed form of AT III bound less strongly to the gel than the free form and that about half of the AT III was free. With further purification a 2.5 × 105 molecular weight complex was isolated. Using 125I labelled human thrombin, this complex was radioactive indicating the presence of thrombin. Only in a synthetic thrombin-AT III system was a 9 × 104 molecular weight complex detected, but not in serum. These facts suggest that in serum AT III complexes may exist in a polymeric form. Also, an AT III antigen derived from the original AT III molecule, but not complexed, was isolated which may be a degradation product.Abbreviations used: AT-III, antithrombin III. Hepes, N-2-Hydroxyethylpiperazine-N-2-Ethanesulphonic acid.

scholarly journals Ultrasound-assisted depolymerization of kappa-carrageenan and characterization of degradation product

2021 ◽  
pp. 105540
Author(s):  
Mariel G. Tecson ◽  
Lucille V. Abad ◽  
Virgilio D. Ebajo ◽  
Drexel H. Camacho
Keyword(s):  
Degradation Product ◽  
Ultrasound Assisted ◽  
Kappa Carrageenan

scholarly journals Evaluation of the Long-Term Storage Stability of the Cyanide Antidote: Dimethyl Trisulfide and Degradation Product Identification

ACS Omega ◽  
2020 ◽  
Vol 5 (42) ◽  
pp. 27171-27179 ◽  
Author(s):  
Indika K. Warnakula ◽  
Afshin Ebrahimpour ◽  
Sun Yi Li ◽  
Ramesha D. Gaspe Ralalage ◽  
Chathuranga C. Hewa-Rahinduwage ◽  
...  
Keyword(s):  
Degradation Product ◽  
Storage Stability ◽  
Dimethyl Trisulfide ◽  
Long Term Storage ◽  
Cyanide Antidote ◽  
Product Identification ◽  
Term Storage

scholarly journals Validated spectral manipulations for determination of an anti-neoplastic drug and its related impurities including its hazardous degradation product

RSC Advances ◽  
2021 ◽  
Vol 11 (35) ◽  
pp. 21332-21342
Author(s):  
Ibrahim A. Naguib ◽  
Eglal A. Abdelaleem ◽  
Eman S. Hassan ◽  
Aml A. Emam
Keyword(s):  
Absorption Spectra ◽  
Degradation Product ◽  
Zero Order ◽  
Sterile Water ◽  
Related Impurities ◽  
Amino Imidazole

Zero order absorption spectra of 12 μg mL−1 of Dacarbazine (), 5-amino-imidazole-4 carboxamide (), and 2-azahypoxanthine (…) using sterile water as a blank.

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