Chemistry of the Podocarpaceae. XLV. Heterocyclic derivatives of 12-Hydroxypodocarpa-8,11,13-trien-19-oic acid

1973 ◽  
Vol 26 (8) ◽  
pp. 1763 ◽  
Author(s):  
GD Beresford ◽  
RC Cambie ◽  
KP Mathai
Keyword(s):  
Hydrazine Hydrate ◽  
Hydroxylamine Hydrochloride ◽  
Heterocyclic Derivatives ◽  
Derivatives Of

The preparation of chromone (11), methylbenzoxazole (18), methylbenzisoxazole (17), flavonoid (12), and benzofuran (19) derivatives from 12-hydroxypodocarpa-8,11,13-trien-19-oic acid (1) is reported. Treatment of the chromone (11) with hydrazine hydrate affords the 3?-phenylpyrazole (20) while treatment with hydroxylamine hydrochloride affords the 3?-phenylisoxazole (21).

Synthetic use of the ribosyl derivatives of 2,4- and 2,5-thiazolidinediones

1979 ◽  
Vol 44 (5) ◽  
pp. 1475-1482 ◽  
Author(s):  
Hubert Hřebabecký ◽  
Zdeněk Točík ◽  
Jiří Beránek
Keyword(s):  
Hydrazine Hydrate ◽  
Hydrogen Chloride ◽  
Sodium Methoxide ◽  
Aqueous Ammonia ◽  
Hydroxylamine Hydrochloride ◽  
Acetyl Derivative ◽  
High Yield ◽  
Derivatives Of ◽  
Methanolic Ammonia

On ribosidation of 2,4-thiazolidinedione (2,5-thiazolidinedione, respectively), the 3-β-D-ribofuranosyl derivative is formed in high yield, either the benzoyl derivative Ia (IIa) or the acetyl derivative Ib (IIb). The unsubstituted ribosyl derivative Ic is formed from the acetyl derivative Ib by methanolic hydrogen chloride. The benzoylated ribosyl-2,4-thiazolidinedione Ia affords the benzoylated ribosylurea III on reaction with aqueous ammonia, the hydroxyethylurea derivative IVa with 2-aminoethanol, the semicarbazide derivative Va with hydrazine hydrate, the ribosylhydroxyurea derivative VIa on reaction with hydroxylamine hydrochloride and triethylamine, the benzoyl derivative of ribosylbiuret VII with O-methylisourea hydrochloride and triethylamine, and (analogously) ribosylisothiobiuret VIII with S-methylisothiourea. Methanolysis of the benzoyl derivative of hydroxyethylurea IVa with sodium methoxide affords the unprotected riboside IVb. Ribosylhydroxyurea VIb is formed on debenzoylation of compound VIa with methanolic ammonia. Acetylation of compound VIb furnishes the pentaacetyl derivative VIc.

New Route Synthesis of Styryl Pyrones: High Yield Synthesis, Reactions and Spectral Properties of 2-Phenyl-6-Styryl-4-Pyrones

2005 ◽  
Vol 2005 (10) ◽  
pp. 654-656 ◽  
Author(s):  
Abdel Moneim El-Ghanam
Keyword(s):  
Hydrazine Hydrate ◽  
Spectral Properties ◽  
Sodium Ethoxide ◽  
Hydroxylamine Hydrochloride ◽  
The Other ◽  
High Yield ◽  
Phosphorus Pentasulfide ◽  
Other Hand ◽  
Synthesis Reactions ◽  
Derivatives Of

2-Phenyl-6-styryl-4-pyrone derivatives have been synthesised from the reaction of ethyl phenylpropiolate with benzylideneacetone derivatives in the presence of sodium ethoxide. Treatment of styrylpyrone with phosphorus pentasulfide gave the corresponding styrylpyran-4-thione which on treatment with hydroxylamine hydrochloride and aqueous methylamine afforded the corresponding oxime and 1-methyl-2-phenyl-6-styrylpyridine-4(1H)-thione, respectively. On the other hand, styrylpyran-4-thione reacted with malononitrile to give pyrolylidenemalononitrile which on treatment with bidentate reagents, hydrazine hydrate, hydroxylamine hydrochloride, thiourea, and thiosemicarbazide afforded the corresponding styrylspiropyran derivatives of pyrazole, 1,2-oxazole or 1,3-thiazine, respectively.

Heterocyclic derivatives of purines. 5. Nucleophilic substitution in series of imidazo[1,2-f]purine derivatives

1984 ◽  
Vol 20 (3) ◽  
pp. 330-334
Author(s):  
S. N. Garmash ◽  
B. A. Priimenko ◽  
N. A. Klyuev ◽  
N. I. Romanenko ◽  
A. K. Sheinkman
Keyword(s):  
Nucleophilic Substitution ◽  
Purine Derivatives ◽  
Heterocyclic Derivatives ◽  
In Series ◽  
Derivatives Of

Angular condensed heterocyclic derivatives of ?-naphthol

1970 ◽  
Vol 6 (4) ◽  
pp. 513-515
Author(s):  
T. Kh. Gladysheva ◽  
M. V. Gorelik
Keyword(s):  
Heterocyclic Derivatives ◽  
Derivatives Of

scholarly journals Synthesis of bis-Heterocyclic Derivatives of Thiohydantoin

INEOS OPEN ◽  
2021 ◽  
Vol 4 ◽  
Author(s):  
O. N. Gorunova ◽  
◽  
N. A. Bystrova ◽  
K. A. Kochetkov ◽  
◽  
...  
Keyword(s):  
Structural Modification ◽  
Suggested Approach ◽  
Heterocyclic Derivatives ◽  
Derivatives Of

The possibility of structural modification of thiohydantoin derivatives via amidoalkylation under the action of a range of cyclic hemiamidals is demonstrated. The suggested approach provides, in particular, unsymmetrical nitrogen-containing bis-heterocyclic systems with pharmacologically relevant groups that are difficult to obtain by other methods.

scholarly journals Synthesis and Evaluation Antibacterial Activity of Some New Substituted 5-Bromoisatin Containing Five, Six Heterocyclic Ring

2016 ◽  
Vol 13 (2) ◽  
pp. 345-359
Author(s):  
Baghdad Science Journal
Keyword(s):  
Heterocyclic Ring ◽  
Absolute Ethanol ◽  
Synthesis Process ◽  
Triazole Derivatives ◽  
Amide Derivatives ◽  
Heterocyclic Derivatives ◽  
Acid Anhydrides ◽  
Specific Reactions ◽  
Derivatives Of ◽  
Product Compound

This research includes the synthesis of some new different heterocyclic derivatives of 5-Bromoisatin. New sulfonylamide, diazine, oxazole, thiazole and 1,2,3-triazole derivatives of 5-Bromoisatin have been synthesized. The synthesis process started by the reaction of 5-Bromoisatin with different reagents to obtain schiff bases of 5-Bromoisatin intermediate compounds(1, 8, 19) by using glacial acetic acid as a catalyst in three routes. The first route, 5-Bromoisatin reacted with p-aminosulfonylchloride to product compound(1), then converted to sulfonyl amide derivatives(2-7) by the reaction of compound(1) with different substituted primary aromatic amine in absolute ethanol. The second route includes the reaction of 5-Bromoisatin reacted with ethyl glycinate to give 5-bromo-3-(Ethyl imino acetate)-2-oxo indole(8), which undergo react with hydrazine hydrate 80% to obtain hydrazine derivatives(9) that react with different acid anhydrides to obtain diazine derivatives(10-14). Also compound(8) reacts with urea and thiourea to give compounds(15,16) which undergo cyclization with p-bromophenacylbromide in absolute ethanol as a solvent to obtain oxazole (17) and thiazole (18), respectively. The third route included the reaction of 5-Bromoisatin with p-phenylenediamine in ethanol to obtain compound(19) which is converted to new substitutes 1,2,3-triazole derivatives(22,23) by diazotation of compound(19) and treating the resulted salt(20) with sodium azid, then acetylaceton or ethylacetoacetate, respectively. Newly synthesized compounds were identified by spectral methods. (FTIR, 1H-NMR, 13C-NMR) and measurements of some of its physical properties and also some specific reactions. Furthermore the effects of the synthesized compounds were studied on some strains of bacteria.

scholarly journals The reactivity of aromatic and heterocyclic derivatives of hydrazine. Vіі. The acid-base properties of substituted 5,7-dichloro-9-hydrazine acridine

2016 ◽  
Vol 0 (1(85)) ◽  
pp. 12-14
Author(s):  
A. O. Deviatkina ◽  
O. M. Svechnikova ◽  
S. V. Kolisnyk ◽  
N. P. Kobzar ◽  
A. F. Vinnyk
Keyword(s):  
Acid Base ◽  
Heterocyclic Derivatives ◽  
Derivatives Of ◽  
Base Properties

scholarly journals Synthesis and characterization of new Oxazine , Thiazine and Pyrazol derived from chalcones

2014 ◽  
Vol 11 (2) ◽  
pp. 477-485 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Nmr Spectroscopy ◽  
Hydrazine Hydrate ◽  
Elemental Analysis ◽  
Potassium Hydroxide ◽  
1H Nmr Spectroscopy ◽  
Room Temperature ◽  
Potassium Hydroxide Solution ◽  
Synthesis And Characterization ◽  
Heterocyclic Derivatives

In this study, chalcones were synthesis by condensing 2-acetylpyridine with aromatic aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation. After that, new heterocyclic derivatives such as Oxazine, Thiazine and Pyrazol were synthesis by reaction between chalcones with urea, thiourea and hydrazine hydrate respectively scheme 1. All these compounds wrer characterization by FTIR, 1H-NMR spectroscopy and elemental analysis.

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