Bisnoriridodial, Bisnoriridolactone, and Related Compounds

1961 ◽  
Vol 14 (2) ◽  
pp. 276 ◽  
Author(s):  
GWK Cavill ◽  
DL Ford
Keyword(s):  
Insecticidal Activity ◽  
Synthetic Compounds ◽  
Naturally Occurring ◽  
Related Compounds

Bisnoriridodial and cis-bisnoriridolactone have been synthesized. The 1,5-dialdehyde-δ-lactone rearrangement of the former compound is compared with that of iridodial. The insecticidal activity of the naturally occurring iridolactones, and of related synthetic compounds, is reported.

scholarly journals Podophyllotoxin: History, Recent Advances and Future Prospects

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 603
Author(s):  
Zinnia Shah ◽  
Umar Farooq Gohar ◽  
Iffat Jamshed ◽  
Aamir Mushtaq ◽  
Hamid Mukhtar ◽  
...  
Keyword(s):  
Structure Optimization ◽  
Cytokine Storm ◽  
Chemotherapeutic Drug ◽  
Future Prospects ◽  
Naturally Occurring ◽  
Pharmacologically Active ◽  
Almost All ◽  
Pharmacologically Active Compounds ◽  
Synthetic Derivatives ◽  
Related Compounds

Podophyllotoxin, along with its various derivatives and congeners are widely recognized as broad-spectrum pharmacologically active compounds. Etoposide, for instance, is the frontline chemotherapeutic drug used against various cancers due to its superior anticancer activity. It has recently been redeveloped for the purpose of treating cytokine storm in COVID-19 patients. Podophyllotoxin and its naturally occurring congeners have low bioavailability and almost all these initially discovered compounds cause systemic toxicity and development of drug resistance. Moreover, the production of synthetic derivatives that could suffice for the clinical limitations of these naturally occurring compounds is not economically feasible. These challenges demanded continuous devotions towards improving the druggability of these drugs and continue to seek structure-optimization strategies. The discovery of renewable sources including microbial origin for podophyllotoxin is another possible approach. This review focuses on the exigency of innovation and research required in the global R&D and pharmaceutical industry for podophyllotoxin and related compounds based on recent scientific findings and market predictions.

Synthesis of demethoxycapillarisin, a naturally occurring 2-phenoxychromone, and related compounds

1981 ◽  
pp. 474 ◽  
Author(s):  
Hidekazu Takeno ◽  
Masashi Hashimoto ◽  
Yoshiyasu Koma ◽  
Haruo Horiai ◽  
Hiroyuki Kikuchi
Keyword(s):  
Naturally Occurring ◽  
Related Compounds

Repellency of Naturally Occurring or Related Compounds, DEET, and Para-Menthane-3,8-Diol to Bed Bugs (Hemiptera: Cimicidae)

2018 ◽  
Vol 55 (3) ◽  
pp. 666-672 ◽  
Author(s):  
John F Anderson ◽  
Francis J Ferrandino ◽  
Michael P Vasil ◽  
Robert H Bedoukian ◽  
Marie Maher ◽  
...  
Keyword(s):  
Bed Bugs ◽  
Naturally Occurring ◽  
Related Compounds

ChemInform Abstract: SYNTHESIS OF DEMETHOXYCAPILLARISIN, A NATURALLY OCCURRING 2-PHENOXYCHROMONE, AND RELATED COMPOUNDS

1981 ◽  
Vol 12 (40) ◽  
Author(s):  
H. TAKENO ◽  
M. HASHIMOTO ◽  
Y. KOMA ◽  
H. HORIAI ◽  
H. KIKUCHI
Keyword(s):  
Naturally Occurring ◽  
Related Compounds
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