Recent Advances in Photodecarboxylations Involving Phthalimides

2018 ◽  
Vol 71 (9) ◽  
pp. 634 ◽  
Author(s):  
Saira Mumtaz ◽  
Mark J. Robertson ◽  
Michael Oelgemöller
Keyword(s):  
Electrochemical Properties ◽  
Continuous Flow ◽  
Coupling Reactions ◽  
Falling Film ◽  
Macrocyclic Compounds ◽  
Reaction Conditions ◽  
Flow Reactors ◽  
Alkyl Radicals ◽  
Highly Efficient ◽  
Continuous Flow Reactors

Owing to their favourable photophysical and electrochemical properties, phthalimides undergo a variety of highly efficient photodecarboxylation reactions. These transformations have been applied to the synthesis of macrocyclic compounds as well as bioactive addition adducts. N-Acetoxyphthalimides are versatile precursors to imidyl and alkyl radicals through photodecarboxylation and have subsequently been used for a variety of coupling reactions. The generally mild reaction conditions make these reactions attractive for green chemical applications. The process protocols were successfully transferred to novel photoreactor devices, among these falling film or continuous flow reactors.

scholarly journals Towards a Novel Computer-Aided Optimization of Microreactors: Techno-Economic Evaluation of an Immobilized Enzyme System

Symmetry ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 524
Author(s):  
Philip Pietrek ◽  
Manfred Kraut ◽  
Roland Dittmeyer
Keyword(s):  
Magnetic Beads ◽  
Glucose Dehydrogenase ◽  
Packed Bed ◽  
Detailed Knowledge ◽  
Reaction Conditions ◽  
Flow Reactors ◽  
Continuous Flow Reactors ◽  
Enzyme Cascades ◽  
And Control ◽  
Physical And Chemical

Immobilized multi-enzyme cascades are increasingly used in microfluidic devices. In particular, their application in continuous flow reactors shows great potential, utilizing the benefits of reusability and control of the reaction conditions. However, capitalizing on this potential is challenging and requires detailed knowledge of the investigated system. Here, we show the application of computational methods for optimization with multi-level reactor design (MLRD) methodology based on the underlying physical and chemical processes. We optimize a stereoselective reduction of a diketone catalyzed by ketoreductase (Gre2) and Nicotinamidadenindinukleotidphosphat (NADPH) cofactor regeneration with glucose dehydrogenase (GDH). Both enzymes are separately immobilized on magnetic beads forming a packed bed within the microreactor. We derive optimal reactor feed concentrations and enzyme ratios for enhanced performance and a basic economic model in order to maximize the techno-economic performance (TEP) for the first reduction of 5-nitrononane-2,8-dione.

Continuous flow reactors: a perspective

2012 ◽  
Vol 14 (1) ◽  
pp. 38-54 ◽  
Author(s):  
Charlotte Wiles ◽  
Paul Watts
Keyword(s):  
Continuous Flow ◽  
Flow Reactors ◽  
Continuous Flow Reactors

Synthesis of Tailored Segmented Polyurethanes Utilizing Continuous-Flow Reactors and Real-Time Process Monitoring

2021 ◽  
Author(s):  
Xabier Lopez de Pariza ◽  
Tim Erdmann ◽  
Pedro L. Arrechea ◽  
Leron Perez ◽  
Charles Dausse ◽  
...  
Keyword(s):  
Real Time ◽  
Process Monitoring ◽  
Continuous Flow ◽  
Time Process ◽  
Flow Reactors ◽  
Segmented Polyurethanes ◽  
Continuous Flow Reactors

Functional Group Interconversion Reactions in Continuous Flow Reactors

2021 ◽  
Vol 25 ◽  
Author(s):  
Alexander Leslie ◽  
Angel Maria Joseph ◽  
Marcus Baumann
Keyword(s):  
Continuous Flow ◽  
Functional Group ◽  
Modern Synthesis ◽  
Flow Reactors ◽  
Flow Synthesis ◽  
Specific Reaction ◽  
Solid Foundation ◽  
Continuous Flow Reactors ◽  
Flow Techniques

: An overview of the current uptake of continuous flow techniques for various functional group interconversion reactions is presented. Besides highlighting a variety of prominent examples and their main features, this review provides insights into specific reaction classes, such as oxidations, reductions, rearrangements as well as different C-H functionalization processes. While this review can only include key examples from the last decade, the reader will find a solid foundation of important transformations along with further references to inform and appreciate the opportunities arising from modern synthesis technologies such as flow synthesis.

Visible light-induced iniferter polymerization of methacrylates enhanced by continuous flow

2017 ◽  
Vol 8 (42) ◽  
pp. 6496-6505 ◽  
Author(s):  
Maarten Rubens ◽  
Phanumat Latsrisaeng ◽  
Tanja Junkers
Keyword(s):  
Block Copolymers ◽  
Visible Light ◽  
Continuous Flow ◽  
Flow Reactors ◽  
Continuous Flow Reactors

Visible-light induced photoiniferter polymerization in continuous flow reactors is very efficient in yielding low dispersity methacrylate block copolymers.

scholarly journals Diels–Alder reactions of myrcene using intensified continuous-flow reactors

2017 ◽  
Vol 13 ◽  
pp. 120-126 ◽  
Author(s):  
Christian H Hornung ◽  
Miguel Á Álvarez-Diéguez ◽  
Thomas M Kohl ◽  
John Tsanaktsidis
Keyword(s):  
Continuous Flow ◽  
Flow Reactor ◽  
Scale Up ◽  
Reaction Times ◽  
Alder Reaction ◽  
Diels Alder ◽  
Flow Reactors ◽  
Diels Alder Reaction ◽  
Naturally Occurring ◽  
Continuous Flow Reactors

This work describes the Diels–Alder reaction of the naturally occurring substituted butadiene, myrcene, with a range of different naturally occurring and synthetic dienophiles. The synthesis of the Diels–Alder adduct from myrcene and acrylic acid, containing surfactant properties, was scaled-up in a plate-type continuous-flow reactor with a volume of 105 mL to a throughput of 2.79 kg of the final product per day. This continuous-flow approach provides a facile alternative scale-up route to conventional batch processing, and it helps to intensify the synthesis protocol by applying higher reaction temperatures and shorter reaction times.

Synthesis of cyclic organic carbonates via catalytic oxidative carboxylation of olefins in flow reactors

2017 ◽  
Vol 7 (1) ◽  
pp. 84-89 ◽  
Author(s):  
Ajay A. Sathe ◽  
Anirudh M. K. Nambiar ◽  
Robert M. Rioux
Keyword(s):  
Carbon Dioxide ◽  
Continuous Flow ◽  
Catalytic Conversion ◽  
Cyclic Carbonates ◽  
Flow Reactors ◽  
Organic Carbonates ◽  
Continuous Flow Reactors

The direct catalytic conversion of olefins into cyclic carbonates using peroxide and carbon dioxide is demonstrated using continuous flow reactors.

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