Synthesis of Highly Enantio-Enriched Heliespirones A and C by a Diastereoselective Aromatic Claisen Rearrangement

2018 ◽  
Vol 71 (5) ◽  
pp. 366
Author(s):  
Philip Norcott ◽  
Christopher S. P. McErlean
Keyword(s):  
Natural Products ◽  
Optical Properties ◽  
Computational Methods ◽  
Claisen Rearrangement ◽  
Synthetic Strategy ◽  
Aromatic Claisen Rearrangement

Computational methods were used to investigate the stereochemical course of the extra-annular Claisen rearrangement. The stereochemical fidelity of the synthetic strategy and comparison of the optical properties support the hypothesis that the heliespirones are scalemic natural products.

Copper-catalyzed alkynylation/annulation cascades of N-allyl ynamides: regioselective access to medium-sized N-heterocycles

2021 ◽  
Vol 8 (1) ◽  
pp. 18-24
Author(s):  
Xu-Heng Yang ◽  
Jian Huang ◽  
Fang Wang ◽  
Zhuoliang Liu ◽  
Yujiao Li ◽  
...  
Keyword(s):  
Claisen Rearrangement ◽  
Synthetic Strategy ◽  
Key Steps

A synthetic strategy based on sequential application of aza-Claisen rearrangement, C–H functionalization, C–N coupling and cyclization as key steps has been developed for the synthesis of 6-, 7-, 8-, and 9-membered rings N-heterocycles.

The Claisen rearrangement in the syntheses of bioactive natural products

Tetrahedron ◽  
2013 ◽  
Vol 69 (34) ◽  
pp. 6921-6957 ◽  
Author(s):  
K.C. Majumdar ◽  
Raj Kumar Nandi
Keyword(s):  
Natural Products ◽  
Claisen Rearrangement ◽  
Bioactive Natural Products

Total synthesis of (±)-heliannuol C and E via aromatic Claisen rearrangement

2005 ◽  
Vol 46 (14) ◽  
pp. 2457-2460 ◽  
Author(s):  
James R. Vyvyan ◽  
Jennifer M. Oaksmith ◽  
Bevin W. Parks ◽  
Elaine M. Peterson
Keyword(s):  
Total Synthesis ◽  
Claisen Rearrangement ◽  
Aromatic Claisen Rearrangement

Computational Work with Natural Products

2013 ◽  
pp. 224-238
Keyword(s):  
Natural Products ◽  
Computational Methods ◽  
Chemical Structures ◽  
Computational Work

This exercises aims to familiarize students with chemical structures of natural products. Students will also use computational methods to learn about trends or the lack thereof in natural products.

The effect of the aliphatic carboxylate linkers on the electronic structures, chemical bonding and optical properties of the uranium-based metal–organic frameworks

RSC Advances ◽  
2015 ◽  
Vol 5 (34) ◽  
pp. 26735-26748 ◽  
Author(s):  
Saumitra Saha ◽  
Udo Becker
Keyword(s):  
Optical Properties ◽  
Detailed Analysis ◽  
Computational Methods ◽  
Chemical Bonding ◽  
Electronic Structures ◽  
Computational Study ◽  
Metal Organic Frameworks ◽  
Metal Organic ◽  
First Time

A series of uranyl containing aliphatic dicarboxylate structures is studied using computational methods. Our computational study provides a detailed analysis of these MOFs and explores the effect of linkers on their properties for the first time.

scholarly journals Development of a Divergent Route to Erythrina Alkaloids

Synlett ◽  
2020 ◽  
Vol 31 (04) ◽  
pp. 327-333 ◽  
Author(s):  
Jesper L. Kristensen ◽  
Sebastian Clementson ◽  
Mikkel Jessing ◽  
Paulo J. Vital
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
19Th Century ◽  
First Generation ◽  
Second Generation ◽  
Enantioselective Synthesis ◽  
Third Generation ◽  
Synthetic Strategy ◽  
Erythrina Alkaloids ◽  
The 19Th Century

Erythrina alkaloids were identified at the end of the 19th century and today, more than 100 members of the erythrinane family have been isolated. They are characterized by a unique tetracyclic, α-tertiary spiroamine scaffold. Herein we detail our efforts towards the development of a divergent enantioselective synthesis of (+)-dihydro-β-erythroidine (DHβE) – one of the most prominent members of this intriguing family of natural products.1 Introduction2 Synthetic Strategy2.1 First Generation2.2 Second Generation2.3 Third Generation2.3.1 Radical Endgame2.3.2 Completion of the Total Synthesis3 Conclusion

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