Iridium-Catalyzed Triborylation of 3-Substituted Indoles

2015 ◽  
Vol 68 (12) ◽  
pp. 1810 ◽  
Author(s):  
Andrew S. Eastabrook ◽  
Jonathan Sperry
Keyword(s):  
1H Nmr ◽  
Nmr Analysis ◽  
One Pot ◽  
Substitution Pattern ◽  
The Third

Readily available 3-substituted indoles undergo a one-pot iridium-catalyzed triborylation at the C2, C5, and C7 sites. 1H NMR analysis indicates borylation at C2 and C7 occurs first (no monoborylated product is observed), with the third borylation occurring as a separate, distinct step that is sterically directed to C5 by a combination of the substituent at C3 and the boronate at C7. The resulting tetrasubstituted indoles possess a substitution pattern that is cumbersome to prepare using existing methods.

Benzimidazole Derivatives as Potential Antimicrobial and Antiulcer Agents: A Mini Review

2019 ◽  
Vol 19 (16) ◽  
pp. 1292-1297 ◽  
Author(s):  
Ali Mohd Ganie ◽  
Ayaz Mahmood Dar ◽  
Fairooz Ahmad Khan ◽  
Bashir Ahmad Dar
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
1H Nmr ◽  
13C Nmr ◽  
Benzimidazole Derivatives ◽  
Spectroscopic Techniques ◽  
One Pot ◽  
Biological Screening ◽  
Elemental Analyses ◽  
Characterization Studies

:Here in we report the number of strategies for the synthesis of differently substituted benzimidazole derivatives. The protocols involved in the syntheses of these derivatives were one-pot or multi-component. The characterization studies of these derivatives were carried by using different spectroscopic techniques (1H NMR, 13C NMR and MS) and elemental analyses. The biological screening studies revealed that these benzimidazole derivatives show potential antibacterial as well as antifungal behavior. These benzimidazole derivatives not only depicted potential antiulcer properties but also showed moderate to good anticancer/cytotoxic behavior against different cancer cell lines.

Polyhydroxyalkanoate quantification in organic wastes and pure cultures using a single-step extraction and 1H NMR analysis

2012 ◽  
Vol 66 (5) ◽  
pp. 1000-1006 ◽  
Author(s):  
Elisabeth Linton ◽  
Asif Rahman ◽  
Sridhar Viamajala ◽  
Ronald C. Sims ◽  
Charles D. Miller
Keyword(s):  
1H Nmr ◽  
Azotobacter Vinelandii ◽  
Nile Blue ◽  
Agricultural Waste ◽  
Accurate Method ◽  
Single Step ◽  
Proton Nuclear Magnetic Resonance ◽  
Copolymer Composition ◽  
Nmr Analysis ◽  
Nmr Method

In this study, a proton nuclear magnetic resonance (1H NMR) method was developed to quantitatively analyze polyhydroxyalkanoate (PHA) content in Cupriavidus necator H16, Azotobacter vinelandii AvOP, and mixed microbial cultures from the effluent of an agricultural waste treatment anaerobic digester. In contrast to previous methods, a single-step PHA extractive method using deuterated chloroform was established, thereby facilitating direct 1H NMR analysis. The accuracy of the method was verified through comparison with well-established gas chromatography (GC) methanolysis techniques. Nile blue fluorescence staining was also carried out to serve as an independent and qualitative indicator of intracellular PHA content. The results indicate that the 1H NMR method is appropriate for rapid and non-destructive quantification of overall PHA content and determination of PHA copolymer composition in a variety of cultures. Notably, this technique was effective in measuring PHA content in full-strength waste samples where high concentrations of background impurities and organic compounds are present. The straightforward procedures minimize error-introducing steps, require less time and materials, and result in an accurate method suitable for routine analyses.

scholarly journals 1H-NMR analysis of the sugar structures of glycoproteins as their pyridylamino derivatives

FEBS Letters ◽  
1986 ◽  
Vol 209 (2) ◽  
pp. 265-268 ◽  
Author(s):  
Satoshi Koyama ◽  
Hiromi Daiyasu ◽  
Sumihiro Hase ◽  
Yuji Kobayashu ◽  
Yoshimasa Kyogoki ◽  
...  
Keyword(s):  
1H Nmr ◽  
Nmr Analysis

Quantitative 1H NMR-analysis of technical octabrominated diphenylether DE-79™ and UV spectra of its components and photolytic transformation products

Chemosphere ◽  
2008 ◽  
Vol 73 (1) ◽  
pp. S44-S52 ◽  
Author(s):  
Ana-Maria Geller ◽  
Heinz-Ulrich Krüger ◽  
Qing Liu ◽  
Cornelius Zetzsch ◽  
Manfred Elend ◽  
...  
Keyword(s):  
1H Nmr ◽  
Transformation Products ◽  
Uv Spectra ◽  
Nmr Analysis

scholarly journals 1H NMR Analysis of Aromatic Polyamide in N-methyl-2-pyroridone Solution

2003 ◽  
Vol 60 (4) ◽  
pp. 186-191
Author(s):  
Hironori MATSUDA ◽  
Shizuo YAMASAKI ◽  
Tetsuo ASAKURA
Keyword(s):  
1H Nmr ◽  
Aromatic Polyamide ◽  
Nmr Analysis

scholarly journals Zinc Chloride Catalyzed Amino Claisen Rearrangement of 1-N-Allylindolines: An Expedient Protocol for the Synthesis of Functionalized 7-Allylindolines

2019 ◽  
Vol 25 (1) ◽  
pp. 22-26 ◽  
Author(s):  
Seema Jain
Keyword(s):  
Zinc Chloride ◽  
Claisen Rearrangement ◽  
Reaction System ◽  
Biologically Active ◽  
Catalyst Loading ◽  
One Pot ◽  
Substitution Pattern ◽  
Claisen Rearrangements ◽  
Lower Temperature ◽  
Molecular Libraries

Abstract7-Allylindolines are valuable synthons for designing biologically active molecular libraries. Lewis acid catalyzed amino-Claisen rearrangement provides a one pot synthetic entry to these heteroarenes. In this context, Zinc chloride (ZnCl2)–N,N-dimethylformamide system efficiently catalyzed amino-Claisen rearrangements of 1-N-allylindolines to 7-allylindolines. The rearrangement is influenced by stereoelectronic effects of substituents present in 1-N-allylindolines. The substrates containing electron donating functionalities underwent rearrangement at lower temperature than substrates with electron withdrawing functional groups. The regioselectivity of the process is governed by the substitution pattern on allyl moiety in 1-N-allylindoline as well as ZnCl2 catalyst loading in the reaction system.

Refining Universal Procedures for Ammonium Quantification via Rapid 1H NMR Analysis for Dinitrogen Reduction Studies

2020 ◽  
Vol 5 (3) ◽  
pp. 736-741 ◽  
Author(s):  
Rebecca Y. Hodgetts ◽  
Alexey S. Kiryutin ◽  
Peter Nichols ◽  
Hoang-Long Du ◽  
Jacinta M. Bakker ◽  
...  
Keyword(s):  
1H Nmr ◽  
Nmr Analysis ◽  
Dinitrogen Reduction

1H NMR analysis of some η6-(substituted aryl phenylsulfonylacetonitrile)-η5-cyclopentadienyliron cations

1994 ◽  
Vol 219 (1-2) ◽  
pp. 221-223 ◽  
Author(s):  
Alaa S. Abd-El-Aziz ◽  
Paul Hazendonk ◽  
Christine R. de Denus ◽  
Harold M. Hutton
Keyword(s):  
1H Nmr ◽  
Nmr Analysis

Chemical characterization of a prominent phosphomonoester resonance from mammalian brain. 31P and 1H NMR analysis at 4.7 and 14.1 tesla

1986 ◽  
Vol 67 (3) ◽  
pp. 443-450 ◽  
Author(s):  
J.W Pettegrew ◽  
S.J Kopp ◽  
J Dadok ◽  
N.J Minshew ◽  
J.M Feliksik ◽  
...  
Keyword(s):  
1H Nmr ◽  
Chemical Characterization ◽  
Mammalian Brain ◽  
Nmr Analysis
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