Use of Ethyl (Benzothiazol-2-ylsulfonyl)acetate for Malonic Ester-type Syntheses of Carboxylic Acids and Esters

2014 ◽  
Vol 67 (9) ◽  
pp. 1222 ◽  
Author(s):  
Waleed M. Hussein ◽  
Ross P. McGeary
Keyword(s):  
Carboxylic Acids ◽  
Alkyl Halides ◽  
Malonic Ester ◽  
One Pot ◽  
Dichloromethane Solution ◽  
Mild Conditions ◽  
Acetic Acids

A new methodology for the synthesis of substituted carboxylic acids is described. Alkylation of either ethyl (benzothiazol-2-ylsulfonyl)acetate or ethyl 2-(benzothiazol-2-ylsulfonyl)propionate was achieved with alkyl halides and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in dichloromethane solution. These products were then desulfinated and hydrolysed in one-pot under mild conditions to give substituted acetic acids in good-to-excellent yields.

ChemInform Abstract: Indium(III)-Catalyzed Reductive Bromination and Iodination of Carboxylic Acids to Alkyl Bromides and Iodides: Scope, Mechanism, and One-Pot Transformation to Alkyl Halides and Amine Derivatives.

ChemInform ◽  
2014 ◽  
Vol 45 (15) ◽  
pp. no-no
Author(s):  
Toshimitsu Moriya ◽  
Shinichiro Yoneda ◽  
Keita Kawana ◽  
Reiko Ikeda ◽  
Takeo Konakahara ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Alkyl Halides ◽  
One Pot ◽  
Alkyl Bromides

One-step Synthesis of β-lactams Using Cyanuric Fluoride

2013 ◽  
Vol 37 (1) ◽  
pp. 25-27 ◽  
Author(s):  
Maaroof Zarei
Keyword(s):  
Reaction Conditions ◽  
One Pot ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
One Step ◽  
Acetic Acids

Cyanuric fluoride works as an efficient acid activator reagent for the direct [2+2] ketene–imine cycloaddition of substituted acetic acids and imines in a one-pot synthesis under mild conditions. The yields are good to excellent and the reaction conditions are mild, simple and efficient.

ChemInform Abstract: ONE POT CONVERSION OF ALKYL HALIDES INTO THIOLS UNDER MILD CONDITIONS

1985 ◽  
Vol 16 (23) ◽  
Author(s):  
P. MOLINA ◽  
M. ALAJARIN ◽  
M. J. VILAPLANA ◽  
A. R. KATRITZKY
Keyword(s):  
Alkyl Halides ◽  
One Pot ◽  
Mild Conditions

One pot conversion of alkyl halides into thiols under mild conditions

1985 ◽  
Vol 26 (4) ◽  
pp. 469-472 ◽  
Author(s):  
P. Molina ◽  
M. Alajarin ◽  
M.J. Vilaplana ◽  
A.R. Katritzky
Keyword(s):  
Alkyl Halides ◽  
One Pot ◽  
Mild Conditions

Indium(III)-Catalyzed Reductive Bromination and Iodination of Carboxylic Acids to Alkyl Bromides and Iodides: Scope, Mechanism, and One-Pot Transformation to Alkyl Halides and Amine Derivatives

2013 ◽  
Vol 78 (21) ◽  
pp. 10642-10650 ◽  
Author(s):  
Toshimitsu Moriya ◽  
Shinichiro Yoneda ◽  
Keita Kawana ◽  
Reiko Ikeda ◽  
Takeo Konakahara ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Alkyl Halides ◽  
One Pot ◽  
Alkyl Bromides

Silver-Promoted Regioselective Oxidative Decarboxylative C–H Alkylation of Phenanthridines with Carboxylic Acids

Synthesis ◽  
2019 ◽  
Vol 52 (02) ◽  
pp. 239-245
Author(s):  
Tianyin Huang ◽  
Yang Yu ◽  
Hui Wang ◽  
Yifan Lin ◽  
Yurui Ma ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Efficient Synthesis ◽  
One Pot ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
The Given

A novel oxidative decarboxylative C–H alkylation of phenanthridines with carboxylic acids was developed for the efficient synthesis of multi-substituted phenanthridine derivatives. The given method features easy availability of starting materials, high regioselectivity, and mild conditions. Furthermore, a one-pot synthesis of multi-substituted phenanthridine derivatives was realized by the reaction of biphenyl isocyanides and carboxylic acid.

Synthesis of 3-(Cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8- carboxylic Acids Via an Efficient Three-component Condensation Reaction between Cyclohexylisocyanide and 2-Aminopyridine-3-carboxylic Acid in the Presence of Aromatic Aldehyde

2018 ◽  
Vol 21 (4) ◽  
pp. 298-301 ◽  
Author(s):  
Ghasem Marandi
Keyword(s):  
Biological Sciences ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
High Performance ◽  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
New Materials ◽  
One Pot ◽  
High Yields ◽  
Benzaldehyde Derivatives

Aim and Objective: The reaction of cyclohexylisocyanide and 2-aminopyridine-3- carboxylic acid in the presence of benzaldehyde derivatives in ethanol led to 3-(cyclohexylamino)-2- arylimidazo[1,2-a]pyridine-8-carboxylic acids in high yields. In a three component condensation reaction, isocyanide reacts with 2-aminopyridine-3-carboxylic acid and aromatic aldehydes without any prior activation. Material and Methods: The synthesized products have stable structures which have been characterized by IR, 1H, 13C and Mass spectroscopy as well as CHN-O analysis. Results: In continuation of our attempts to develop simple one-pot routes for the synthesis of 3- (cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids, aromatic aldehydes with divers substituted show a high performance. Conclusion: In conclusion, this study introduces the art of combinatorial chemistry using a simple one-pot procedure for the synthesis of new materials which are interesting compounds in medicinal and biological sciences.

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