scholarly journals Guanidine Motif in Biologically Active Peptides

2014 ◽  
Vol 67 (7) ◽  
pp. 965 ◽  
Author(s):  
Juan V. Alegre-Requena ◽  
Eugenia Marqués-López ◽  
Raquel P. Herrera
Keyword(s):  
Hydrogen Bond ◽  
Natural Products ◽  
Organic Synthesis ◽  
Biologically Active ◽  
Metal Salts ◽  
Structural Motif ◽  
Active Peptides ◽  
The Past ◽  
Wide Range ◽  
Biologically Active Peptides

In the past decade, guanidines have attracted attention as valuable hydrogen bond-based catalysts while they have long been considered as organic superbases with a broad scope of synthetic applicability. Their easy modification has also expanded their capacity to form complexes with a wide range of metal salts as effective metal scavengers. All these attractive aspects have promoted a huge growth in the field of organic synthesis involving guanidines and examples of such reactions have been collected in numerous reviews and some books. Moreover, this structural motif is also present in a large number of natural products and biologically active compounds that exhibit appealing properties and play important roles in medicinal chemistry. In this highlight, we will only cover the synthesis and properties of biologically active guanidine-containing peptides reported in the past 3 years.

scholarly journals The Pathways Involved in TLQP-62 Mediated Biological Functions

2018 ◽  
Vol 7 (1) ◽  
pp. 953-966
Author(s):  
Md. Shamim Akhter ◽  
Jojon Arif
Keyword(s):  
Biological Function ◽  
Biological Effects ◽  
Neuroendocrine Cells ◽  
Biologically Active ◽  
Active Peptides ◽  
Mediated Action ◽  
Wide Range ◽  
Biologically Active Peptides ◽  
Review Study ◽  
Inducible Gene

VGF is neurosecretory protein, belongs to the extendedgranin family of proteins, originallyrecognized as a nerve growth factor (NGF) inducible gene product. It is selectively synthesized mostly in neuronal and neuroendocrine cells. It has a very simple organization. It has several biologically active peptides, described as VGF-derived peptides including APPG-40, APPG-37, GRPE-37, NERP-1, NERP-2, NAPP-129 (VGF 20), VGF 18, HFHH-51 (VGF 6), HHPD-1, AQEE-30 (Peptide V), LQEQ-19, TLQP-21 and TLQP-62 (VGF 10). Among these peptides TLQP-62 is of great significance because of its several remarkable biological effects like regulation of memory formation, glucose homeostasis and insulin secretion, gene transcription, neurogenesis, etc. Although in light of these outstanding behavioral and physiological roles, very few information are available regarding its mode of action. Still, no receptor has been found for TLQP-62 mediated cascading pathways. However, considering the significant biological function of TLQP-62, this review study was done to summarize the pathways involved in TLQP-62 mediated action, based on the information till now. TLQP-62 activates signal transduction cascades by two mechanisms including opening of the calcium channels and modulating the AMPK, PKC and ERK pathways. These events result in an increase in intracellular Ca2+ concentration which permits the secretion of insulin. TLQP-62 would be a significant therapeutics and drug discovery tool for a wide range of diseases to which the peptide related, if TLQP-62 mediated pathways are known, as a whole.

scholarly journals Gold-Catalyzed Complementary Nitroalkyne Internal Redox Process: A DFT Study

2021 ◽  
Vol 9 ◽  
Author(s):  
K. Vipin Raj ◽  
Pawan S. Dhote ◽  
Kumar Vanka ◽  
Chepuri V. Ramana
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Gold Catalysis ◽  
Redox Process ◽  
Biologically Active ◽  
Dft Study ◽  
Relative Stabilities ◽  
Wide Range ◽  
Theoretical Investigations ◽  
Synthetic Methodologies

Gold-catalysis, in this century, is one of the most emerging and promising new areas of research in organic synthesis. During the last two decades, a wide range of distinct synthetic methodologies have been unveiled employing homogeneous gold catalysis and aptly applied in the synthesis of numerous natural products and biologically active molecules. Among these, the reactions involving α-oxo gold carbene/α-imino gold carbene intermediates are of contemporary interest, in view of their synthetic potential and also due to the need to understand the bonding involved in these complexes. In this manuscript, we document the theoretical investigations on the regio-selectivity dependence of substitution on the gold-catalyzed cycloisomerization of o-nitroarylalkyne derivatives. We have also studied the relative stabilities of α-oxo gold carbene intermediates.

From Nucleic Acids to Drug Discovery: Nucleobases as Emerging Templates for Drug Candidates

2021 ◽  
Vol 28 ◽  
Author(s):  
Xi Khai Wong ◽  
Keng Yoon Yeong
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Bacterial Infections ◽  
Review Article ◽  
Biologically Active ◽  
Structural Motif ◽  
Natural Sources ◽  
Drug Candidates ◽  
The Past ◽  
Current State

: Nucleobases represent key structural motif in biologically active molecules including synthetic and natural products. Molecular modifications made on nucleobases or their isolation from natural sources are being widely investigated for the development of drugs with improved potency for the treatment of different diseases, such as cancer, as well as viral and bacterial infections. This review article focuses on the nucleobase analogue drug developments of the past 20 years (2000-2020). Various pharmacological and medicinal aspects of nucleobases and their analogues are discussed. The current state and limitations are also highlighted.

Copper-catalyzed N-arylation of pyrroles: An overview

2021 ◽  
Author(s):  
Kalathingal Nasreen Hisana ◽  
C. M. A. Afsina ◽  
Gopinathan Anilkumar
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Wide Range

N-Arylated pyrroles have a wide range of applications in pharmaceuticals, agrochemical industry and organic synthesis. They are intermediates for the formation of many biologically active compounds and natural products. Over...

scholarly journals Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 249
Author(s):  
Raquel G. Soengas ◽  
Humberto Rodríguez-Solla
Keyword(s):  
Organic Chemistry ◽  
Natural Products ◽  
Functional Group ◽  
Biological Activities ◽  
Synthetic Methods ◽  
Bond Forming ◽  
Drug Candidates ◽  
The Past ◽  
Wide Range

The 1,3-butadiene motif is widely found in many natural products and drug candidates with relevant biological activities. Moreover, dienes are important targets for synthetic chemists, due to their ability to give access to a wide range of functional group transformations, including a broad range of C-C bond-forming processes. Therefore, the stereoselective preparation of dienes have attracted much attention over the past decades, and the search for new synthetic protocols continues unabated. The aim of this review is to give an overview of the diverse methodologies that have emerged in the last decade, with a focus on the synthetic processes that meet the requirements of efficiency and sustainability of modern organic chemistry.

scholarly journals Concepts for Biologically Active Peptides

2010 ◽  
Vol 16 (30) ◽  
pp. 3390-3400 ◽  
Author(s):  
Abba J. Kastin ◽  
Weihong Pan
Keyword(s):  
Biologically Active ◽  
Active Peptides ◽  
Biologically Active Peptides
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