The Synthesis of Fluorescent DNA Intercalator Precursors through Efficient Multiple Heck Reactions

2011 ◽  
Vol 64 (3) ◽  
pp. 316 ◽  
Author(s):  
Nigel A. Lengkeek ◽  
Ramiz A. Boulos ◽  
Allan J. McKinley ◽  
Thomas V. Riley ◽  
Boris Martinac ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Benzene Derivatives ◽  
Efficient Synthesis ◽  
Heck Reactions ◽  
Dna Intercalator ◽  
Highly Efficient ◽  
Cross Coupling Reaction ◽  
Efficient Route

A highly efficient synthesis of p-carboethoxy-tristyryl and carboethoxy-terastyrenyl benzene derivatives through a multiple Heck cross coupling reaction is reported. This reaction provides an efficient route to DNA intercalator precursors containing a benzene core.

C–N cross-coupling reaction catalysed by reusable CuCr2O4 nanoparticles under ligand-free conditions: a highly efficient synthesis of triarylamines

RSC Advances ◽  
2015 ◽  
Vol 5 (37) ◽  
pp. 28879-28884 ◽  
Author(s):  
Javad Safaei-Ghomi ◽  
Zeinab Akbarzadeh ◽  
Bahareh Khojastehbakht-Koopaei
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Efficient Synthesis ◽  
Highly Efficient ◽  
Aryl Iodides ◽  
Cross Coupling Reaction ◽  
Ligand Free

A convenient, efficient and ligand-free method for the C–N coupling reaction of anilines and aryl iodides was performed using CuCr2O4 nanoparticles.

An Efficient Synthesis of Optically Active 4-Benzyloxy-3-hydoroxy-1-butyne and Its Cross-Coupling Reaction

Heterocycles ◽  
1992 ◽  
Vol 33 (2) ◽  
pp. 831 ◽  
Author(s):  
Seiichi Takano ◽  
Masashi Akiyama ◽  
Takumichi Sugihara ◽  
Kunio Ogasawara
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Optically Active ◽  
Efficient Synthesis ◽  
Cross Coupling Reaction

Synthesis and Application of Tetrafluoroethylene (CF2CF2)-Containing Acetylene Derivatives

Synthesis ◽  
2020 ◽  
Vol 52 (13) ◽  
pp. 1947-1958
Author(s):  
Tsutomu Konno ◽  
Gen Egashira ◽  
Chihiro Kajimoto ◽  
Takuto Kataoka ◽  
Shigeyuki Yamada
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Alder Reaction ◽  
Diels Alder ◽  
Benzene Derivatives ◽  
Diels Alder Reaction ◽  
Cross Coupling Reaction ◽  
Oxidative Aromatization ◽  
High Yields ◽  
Acetylene Derivatives

On treating 1,3,4-tribromo-1,1,2,2-tetrafluorobutane, readily prepared from commercially available 4-bromo-3,3,4,4-tetrafluorobut-1-ene, with 3.3 equivalents of LHMDS at 0 °C in THF, the corresponding lithium acetylide could be prepared quantitatively. The acetylide reacted well with various aldehydes, ketones, or chlorosilanes to give the corresponding acetylene derivatives in high yields. It was also found that various iodoarenes could participate in the cross-coupling reaction with the zinc acetylide, readily prepared from the lithium acetylide and ZnCl2·TMEDA complex, in the presence of Pd(PPh3)4 to bring about the adducts in high yields. Thus-obtained acetylene derivatives underwent smooth Diels–Alder reaction with various 1,3-dienes to afford the corresponding 1,4- or 1,3-cyclohexadiene derivatives. In addition, it was revealed that the oxidative aromatization of the resulting cyclohexadiene derivatives with DDQ took place very smoothly, providing the multi-substituted benzene derivatives having a tetrafluoro­ethylene group.

scholarly journals Pd(CH3CN)2Cl2/Pipecolinic Acid as a Highly Efficient Catalytic System for Suzuki-Miyaura Cross-coupling Reaction of Bromoaryl Carboxylic Acids in Water

Catalysts ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 86 ◽  
Author(s):  
Xiaogang Li ◽  
Wenbin Zhang ◽  
Leiqing Fu ◽  
Mengping Guo
Keyword(s):  
Catalytic System ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Catalytic Performance ◽  
High Turnover ◽  
Mild Conditions ◽  
Highly Efficient ◽  
Cross Coupling Reaction ◽  
Pipecolinic Acid ◽  
Excellent Catalytic Performance

In this study, a convenient and highly efficient catalytic system for the Suzuki-Miyaura coupling reaction was investigated under mild conditions. A combination of Pd(CH3CN)2Cl2 and pipecolinic acid showed excellent catalytic performance and afforded high turnover numbers; turnover numbers were up to 4.9 × 105 for the coupling reaction of 4-bromobenzoic acid and tetraphenylboron sodium. The catalytic system was also effective for the indexes of 4-bromobenzoic acid, and high turnover numbers were obtained.

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