Uncatalyzed Reactions in Aqueous Media: Three-Component, One-Pot, Clean Synthesis of Tetrahydrobenzo[b]pyran Derivatives

2007 ◽  
Vol 60 (4) ◽  
pp. 305 ◽  
Author(s):  
Sunita B. Bandgar ◽  
Babasaheb P. Bandgar ◽  
Balaji L. Korbad ◽  
Jalinder V. Totre ◽  
Sachin Patil
Keyword(s):  
Aqueous Medium ◽  
Aqueous Media ◽  
Aromatic Aldehydes ◽  
Pure Form ◽  
One Pot ◽  
Clean Synthesis ◽  
Neutral Conditions

The synthesis of various tetrahydrobenzo[b]pyran derivatives has been carried out by means of an uncatalyzed, three-component, one-pot clean condensation of aromatic aldehydes, reactive methylene compounds, and dimidone in aqueous medium. Simple workup, and mild and neutral conditions that give quantitative yields of products in pure form, are the attractive features of this method.

TiO2 Nanoparticles as an Efficient Catalyst for the One-pot Preparation of Tetrahydrobenzo[c]acridines in Aqueous Media

2013 ◽  
Vol 68 (4) ◽  
pp. 362-366 ◽  
Author(s):  
Shahrzad Abdolmohammadi ◽  
Mahdieh Mohammadnejad ◽  
Faezeh Shafaei
Keyword(s):  
Ammonium Acetate ◽  
Titanium Dioxide Nanoparticles ◽  
Aqueous Media ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
One Pot ◽  
Efficient Catalyst ◽  
The One ◽  
Work Up ◽  
Operational Simplicity

A series of tetrahydrobenzo[c]acridinone derivatives have been prepared by a one-pot fourcomponent reaction of 1-naphthol, aromatic aldehydes, dimedone, and ammonium acetate in aqueous media using a catalytic amount of titanium dioxide nanoparticles (TiO2 NPs). The advantages of this novel protocol include the excellent yields, operational simplicity, short reaction time, easy work-up, reusability of the catalyst and an environmentally friendly procedure.

scholarly journals Synthesis of Functionalized Dihydropyrido[2,3-d]pyrimidines in Aqueous Medium

SynOpen ◽  
2018 ◽  
Vol 02 (01) ◽  
pp. 0001-0005 ◽  
Author(s):  
Saeed Balalaie ◽  
Hamed Esmaeilabadi ◽  
Saber Mehrparvar ◽  
Frank Rominger ◽  
Fatima Hamdan ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Aqueous Media ◽  
Aromatic Aldehydes ◽  
Cascade Reaction ◽  
Hydrogen Phosphate ◽  
Diammonium Hydrogen Phosphate ◽  
Diammonium Hydrogen

Synthesis of functionalized 2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one from a cascade reaction between 3-formylchromone, malononitrile, diammonium hydrogen phosphate, and aromatic aldehydes in aqueous media is described.

Uncatalyzed Reactions in Aqueous Media: Three-Component, One-Pot, Clean Synthesis of Tetrahydrobenzo[b]pyran Derivatives.

ChemInform ◽  
2007 ◽  
Vol 38 (38) ◽  
Author(s):  
Sunita B. Bandgar ◽  
Babasaheb P. Bandgar ◽  
Balaji L. Korbad ◽  
Jalinder V. Totre ◽  
Sachin Patil
Keyword(s):  
Aqueous Media ◽  
One Pot ◽  
Clean Synthesis

Kröhnke reaction in aqueous media: one-pot clean synthesis of 4′-aryl-2,2′:6′,2″-terpyridines

Tetrahedron ◽  
2007 ◽  
Vol 63 (2) ◽  
pp. 381-388 ◽  
Author(s):  
Shujiang Tu ◽  
Runhong Jia ◽  
Bo Jiang ◽  
Junyong Zhang ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Aqueous Media ◽  
One Pot ◽  
Clean Synthesis ◽  
Kröhnke Reaction

Green Synthesis of 4-aryl-3,4-Dihydrochromeno[3,4-e][1,3]Oxazine-2,5-Dione in Aqueous Media by Condensation of 4-Hydroxycoumarin with Aromatic Aldehydes and Methyl Carbamate

2017 ◽  
Vol 41 (3) ◽  
pp. 136-138 ◽  
Author(s):  
Sabereh Bougan ◽  
Alireza Hassanabadi
Keyword(s):  
Green Chemistry ◽  
Organic Solvent ◽  
Green Synthesis ◽  
Aqueous Media ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Efficient Synthesis ◽  
One Pot ◽  
Three Component Reaction ◽  
High Yields

A green and efficient synthesis of the title compounds has been achieved in a one-pot, three-component reaction of 4-hydroxycoumarin and aromatic aldehydes with methyl carbamate catalysed by p-toluenesulfonic acid in aqueous media to afford 4-aryl-3,4-dihydrochromeno[3,4-e][1,3]oxazine-2,5-diones in excellent yields. The salient features of this protocol are: short reaction times, high yields and absence of any hazardous organic solvent. Consequently, this procedure could be classified as green chemistry.

scholarly journals Poly(4-Vinylpyridinium)Hydrogen Sulfate Catalyzed an Efficient and Ecofriendly Protocol for the One-Pot Multicomponent Synthesis of 1,8-Acridinediones in Aqueous Medium

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Janardhan Banothu ◽  
Rajitha Bavantula ◽  
Peter A. Crooks
Keyword(s):  
Aqueous Medium ◽  
Ammonium Acetate ◽  
Aromatic Aldehydes ◽  
Hydrogen Sulfate ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Multicomponent Condensation ◽  
Green Protocol ◽  
The One ◽  
Work Up

Highly efficient, ecofriendly, and improved protocol for the synthesis of 1,8-acridinediones has been developedviaone-pot multicomponent condensation of 1,3-cyclohexanedione/dimedone, aromatic aldehydes, and ammonium acetate utilizing poly(4-vinylpyridinium)hydrogen sulfate as catalyst in aqueous medium. Excellent yields in shorter reaction time, simple work-up procedure, easy recovery, and reusability of the catalyst are attractive features of this green protocol.

scholarly journals AN EFFICIENT, GREEN, CATALYST FREE SYNTHESIS AND CRYSTALLOGRAPHIC STUDY OF BENZO-4H-PYRANS IN AQUEOUS MEDIUM

2019 ◽  
Vol 9 (4-A) ◽  
pp. 280-289
Author(s):  
SEKAR SILAMBU SILAMBARASAN ◽  
A. Jamal Abdul Nasser
Keyword(s):  
Single Crystal ◽  
Aqueous Medium ◽  
Michael Addition ◽  
Aromatic Aldehydes ◽  
Environmentally Benign ◽  
Monoclinic Space Group ◽  
One Pot ◽  
Green Catalyst ◽  
Space Group ◽  
High Yields

A highly efficient and environmentally benign for the synthesis a of 2-amino-7-hydroxy-4-aryl-4H-chromene-3-carbonitrile derivatives (4a-n) in good to high yields (90%-97%) by one-pot three-component Michael addition reaction of malononitrile, aromatic aldehydes and resorcinol under reflux condition was developed in aqueous medium. Single crystal X-ray studies show that 4h crystallizes in the formula C22H15Cl2N2O2, Mr=410.26, Monoclinic, Space group P2(1)/c, a=12.753(9)Å, b=6.665(4)Å, c=24.050(14) Å, β=102.95(3)A° and 4i C16H10Cl2N2O2, Mr=333.16, Triclinic, Space group P-1, a=6.271(3)Å, b=18.697(5)Å, c =13.794(7) Å,  β =94.269(17)A°. The structure of the products were further confirmed by 1H NMR, 13C NMR, IR and Mass spectrum. Keywords: Benzopyrans, malononitrile, resorcinol, Michael addition, water mediated synthesis, single crystal XRD

Potassium phthalimide-catalysed one-pot multi-component reaction for efficient synthesis of amino-benzochromenes in aqueous media

2014 ◽  
Vol 68 (8) ◽  
Author(s):  
Hamzeh Kiyani ◽  
Fatemeh Ghorbani
Keyword(s):  
Organic Solvent ◽  
Aqueous Media ◽  
Ethyl Cyanoacetate ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Environmentally Benign ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
High Yields

Abstract2-Amino-4-aryl-4H-benzo[h]chromenes and 3-amino-1-aryl-1H-benzo[f]chromenes were prepared by treating cyano-methylene compounds (malononitrile or ethyl cyanoacetate), substituted aromatic aldehydes, and naphtholic compounds in the presence of potassium phthalimide as a green, mild, efficient, and commercially available organocatalyst in aqueous media. The procedure was readily conducted and affords remarkable advantages such as safety, short reaction times, environmentally benign milder reaction conditions, no organic solvent required, and high yields.

scholarly journals Three-Component One-Pot Condensation of 2-Hydroxy-1,4-Naphthoquinone with Aromatic Aldehydes and Methyl Carbamate: Synthesis of 4-aryl-3,4-Dihydronaphtho[3,4-e][1,3]Oxazine-2,5,10-Trione in Aqueous Media

2018 ◽  
Vol 42 (6) ◽  
pp. 291-293
Author(s):  
Nooshin Ghaffari-Nia ◽  
Alireza Hassanabadi
Keyword(s):  
Green Chemistry ◽  
Organic Solvent ◽  
Efficient Method ◽  
Aqueous Media ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
One Pot ◽  
One Pot Condensation ◽  
Oxazine Ring ◽  
High Yields

A green and efficient method for oxazine ring formation is established using the reaction of 2-hydroxy-1,4-naphthoquinone and aromatic aldehydes with methyl carbamate catalysed by p-toluenesulfonic acid in aqueous media to afford 4-aryl-3,4-dihydronaphtho[3,4- e][1,3] oxazine-2,5,10-triones in excellent yields. The salient features of this protocol are short reaction times and high yields while avoiding any hazardous organic solvent. Therefore, this procedure could be classified as green chemistry.

Heterogeneous recyclable nano-CeO2 catalyst: efficient and eco-friendly synthesis of novel fused triazolo and tetrazolo pyrimidine derivatives in aqueous medium

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 68788-68797 ◽  
Author(s):  
Lingala Suresh ◽  
P. Sagar Vijay Kumar ◽  
T. Vinodkumar ◽  
G. V. P. Chandramouli
Keyword(s):  
Aqueous Medium ◽  
Condensation Reaction ◽  
Bond Formation ◽  
Aromatic Aldehydes ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Multicomponent Condensation ◽  
The One

A ceria nanocatalyst was used for the one-pot, multicomponent condensation reaction of benzoylacetonitrile, aromatic aldehydes and 5-amino-triazole/tetrazole proceeding via C–C and C–N bond formation to deliver triazolo/tetrazolo[1,5-a]pyrimidines.

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