A Simple Approach to Micro-Patterned Surfaces by Breath Figures with Internal Structure Using Thermoresponsive Amphiphilic Block Copolymers

2005 ◽  
Vol 58 (8) ◽  
pp. 595 ◽  
Author(s):  
Alexandra Nygard ◽  
Thomas P. Davis ◽  
Christopher Barner-Kowollik ◽  
Martina H. Stenzel
Keyword(s):  
Block Copolymers ◽  
Casting Process ◽  
Amphiphilic Block Copolymers ◽  
Patterned Surfaces ◽  
Stimuli Responsive ◽  
Porous Films ◽  
Breath Figures ◽  
Angle Measurements ◽  
Isopropyl Acrylamide ◽  
Contact Angle Measurements

Employing amphiphilic block copolymers in a casting process to obtain honeycomb-structured films via breath figures leads to a suborder of these porous films. A thermoresponsive block copolymer, polystyrene-block-poly(N-isopropyl acrylamide), was synthesized and used to test the arrangement of both blocks within the honeycomb-structured films. Contact angle measurements reveal that the surface of these films has a different composition compared to the structure of the pores. The pores were found to be enriched in hydrophilic sequences showing stimuli-responsive behavior, whereas the surface reacts like a typical hydrophobic porous film.

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

scholarly journals Antimicrobial Porous Surfaces Prepared by Breath Figures Approach

Materials ◽  
2018 ◽  
Vol 11 (8) ◽  
pp. 1266 ◽  
Author(s):  
Alexandra Muñoz-Bonilla ◽  
Rocío Cuervo-Rodríguez ◽  
Fátima López-Fabal ◽  
José Gómez-Garcés ◽  
Marta Fernández-García
Keyword(s):  
Block Copolymers ◽  
Side Chain ◽  
Porous Films ◽  
Narrow Pore Size Distribution ◽  
Breath Figures ◽  
Gram Positive Bacteria ◽  
Alkyl Groups ◽  
Porous Surfaces ◽  
Cationic Copolymers ◽  
Ordered Porous

Herein, efficient antimicrobial porous surfaces were prepared by breath figures approach from polymer solutions containing low content of block copolymers with high positive charge density. In brief, those block copolymers, which were used as additives, are composed of a polystyrene segment and a large antimicrobial block bearing flexible side chain with 1,3-thiazolium and 1,2,3-triazolium groups, PS54-b-PTTBM-M44, PS54-b-PTTBM-B44, having different alkyl groups, methyl or butyl, respectively. The antimicrobial block copolymers were blended with commercial polystyrene in very low proportions, from 3 to 9 wt %, and solubilized in THF. From these solutions, ordered porous films functionalized with antimicrobial cationic copolymers were fabricated, and the influence of alkylating agent and the amount of copolymer in the blend was investigated. Narrow pore size distribution was obtained for all the samples with pore diameters between 5 and 11 µm. The size of the pore decreased as the hydrophilicity of the system increased; thus, either as the content of copolymer was augmented in the blend or as the copolymers were quaternized with methyl iodide. The resulting porous polystyrene surfaces functionalized with low content of antimicrobial copolymers exhibited remarkable antibacterial efficiencies against Gram positive bacteria Staphylococcus aureus, and Candida parapsilosis fungi as microbial models.

Synthesis and self-assembly of photoacid-containing block copolymers based on 1-naphthol

2019 ◽  
Vol 10 (41) ◽  
pp. 5602-5616 ◽  
Author(s):  
Felix Wendler ◽  
Jessica C. Tom ◽  
Felix H. Schacher
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Molecular Switches ◽  
Amphiphilic Block Copolymers ◽  
Strong Increase ◽  
Stimuli Responsive ◽  
Responsive Materials

Photoacids experience a strong increase in acidity when absorbing light and, hence, can be considered as molecular switches. The incorporation into amphiphilic block copolymers leads to novel stimuli-responsive materials with great potential.

Honeycomb structured porous films from amphiphilic block copolymers prepared via RAFT polymerization

Polymer ◽  
2007 ◽  
Vol 48 (17) ◽  
pp. 4950-4965 ◽  
Author(s):  
Kok Hou Wong ◽  
Thomas P. Davis ◽  
Christopher Barner-Kowollik ◽  
Martina H. Stenzel
Keyword(s):  
Block Copolymers ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Porous Films

Systematic Investigation on the Formation of Honeycomb-Patterned Porous Films from Amphiphilic Block Copolymers

2015 ◽  
Vol 119 (4) ◽  
pp. 1971-1979 ◽  
Author(s):  
Bai-Heng Wu ◽  
Liang-Wei Zhu ◽  
Yang Ou ◽  
Wen Tang ◽  
Ling-Shu Wan ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Systematic Investigation ◽  
Amphiphilic Block Copolymers ◽  
Porous Films

scholarly journals Gold-Loaded Organic/Inorganic Nanocomposite Honeycomb Membranes

2006 ◽  
Vol 59 (8) ◽  
pp. 539 ◽  
Author(s):  
Kok Hou Wong ◽  
Thomas P. Davis ◽  
Christopher Barner-Kowollik ◽  
Martina H. Stenzel
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Raft Polymerization ◽  
Porous Films ◽  
Breath Figures ◽  
Vinyl Pyridine ◽  
Self Assembled ◽  
Gold Nanocomposites ◽  
Hydrolysis Of ◽  
Porous Array

RAFT polymerization was used to prepare polystyrene – poly(4-vinyl pyridine) block copolymers, PSn-b-P(4VP)m. Well-defined block copolymers were obtained despite some indications of hydrolysis of the RAFT endgroup during synthesis. The block copolymer PS70-b-P(4VP)55 was self-assembled into micellar structures in dichloromethane, leading to nanoparticles with hydrodynamic diameters of 70 nm. The micelles were loaded with HAuCl4 and, upon reduction, micellar gold-containing nanoparticles with hydrodynamic diameters of 240 nm were obtained. These nanoparticles were employed in the preparation of honeycomb-structured porous films by means of the breath figures technique to yield gold nanocomposites with a hexagonal porous array.

scholarly journals Novel Amphiphilic Block Copolymers for the Formation of Stimuli-Responsive Non-Lamellar Lipid Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3648
Author(s):  
Jiali Zhai ◽  
Bo Fan ◽  
San H. Thang ◽  
Calum J. Drummond
Keyword(s):  
Block Copolymers ◽  
Drug Release ◽  
Liquid Crystalline ◽  
Lipid Nanoparticles ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Control Drug ◽  
Reversible Addition ◽  
Poly Ethylene ◽  
Internal Particle

Non-lamellar lyotropic liquid crystalline (LLC) lipid nanoparticles contain internal multidimensional nanostructures such as the inverse bicontinuous cubic and the inverse hexagonal mesophases, which can respond to external stimuli and have the potential of controlling drug release. To date, the internal LLC mesophase responsiveness of these lipid nanoparticles is largely achieved by adding ionizable small molecules to the parent lipid such as monoolein (MO), the mixture of which is then dispersed into nanoparticle suspensions by commercially available poly(ethylene oxide)–poly(propylene oxide) block copolymers. In this study, the Reversible Addition-Fragmentation chain Transfer (RAFT) technique was used to synthesize a series of novel amphiphilic block copolymers (ABCs) containing a hydrophilic poly(ethylene glycol) (PEG) block, a hydrophobic block and one or two responsive blocks, i.e., poly(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acrylate) (PTBA) and/or poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA). High throughput small angle X-ray scattering studies demonstrated that the synthesized ABCs could simultaneously stabilize a range of LLC MO nanoparticles (vesicles, cubosomes, hexosomes, inverse micelles) and provide internal particle nanostructure responsiveness to changes of hydrogen peroxide (H2O2) concentrations, pH and temperature. It was found that the novel functional ABCs can substitute for the commercial polymer stabilizer and the ionizable additive in the formation of next generation non-lamellar lipid nanoparticles. These novel formulations have the potential to control drug release in the tumor microenvironment with endogenous H2O2 and acidic pH conditions.

Copper-Coordination Induced Fabrication of Stimuli-Responsive Polymersomes from Amphiphilic Block Copolymer Containing Pendant Thioethers

2021 ◽  
Author(s):  
Shuqi Dong ◽  
Li Liu ◽  
Hanying Zhao
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Amphiphilic Block Copolymer ◽  
Stimuli Responsive ◽  
Copper Coordination

In this work, we synthesized oxidation-responsive amphiphilic block copolymers PEG45-b-P(MET/PBC)n bearing pendant phenylboronic ester carbamate (PBC) and thioether moieties in the hydrophobic block by RAFT polymerization and post-polymerization modification. As...

Sign in / Sign up

Export Citation Format

Share Document