Synthesis and Binding Studies of a New DNA Minor Groove Binder

1998 ◽  
Vol 51 (3) ◽  
pp. 243 ◽  
Author(s):  
Christopher I. Clark ◽  
David P. Kelly ◽  
Roger F. Martin ◽  
Jonathan M. White ◽  
Pavel Lobachevsky
Keyword(s):  
Minor Groove ◽  
Minor Groove Binder ◽  
Binding Studies ◽  
Dna Minor Groove ◽  
Indole Synthesis ◽  
Dna Minor Groove Binder

2-[2′-(4′′-Ethoxyphenyl)-1H-indol-6′-yl]-5-(4′′′-methylpiperazin-1′′′-yl)-1H-benzimidazole (1) has been synthesized from 2-(4′-ethoxyphenyl)-1H-indole-6-carbaldehyde (4b) and 4-(4′-methylpiperazin-1′-yl)benzene-1,2-diamine (3b). The aldehyde (4b) was prepared in five steps by using a modified Leimgruber–Batcho indole synthesis. Evaluation of (1) as a DNA ligand is described.

DNA Binding Compounds. VII. Synthesis, Characterization and DNA Binding Capacity of 1,2-Dicarba-closo-dodecaborane Bibenzimidazoles Related to the DNA Minor Groove Binder Hoechst 33258

1999 ◽  
Vol 52 (4) ◽  
pp. 291 ◽  
Author(s):  
Stuart A. Bateman ◽  
David P. Kelly ◽  
Jonathan M. White ◽  
Roger F. Martin
Keyword(s):  
Dna Binding ◽  
Binding Capacity ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Hoechst 33258 ◽  
Binding Studies ◽  
Dna Minor Groove ◽  
Dna Binding Studies ◽  
Carborane Ligand ◽  
Dna Minor Groove Binder

A series of bibenzimidazole derivatives based on the known DNA minor groove binder Hoechst 33258 have been prepared to include a 1,2-dicarba-closo-dodecaborane cage for potential use in boron neutron capture therapy (BNCT). The carborane derivatives (5){(7) were chosen to reduce the steric inhibition of minor groove DNA binding displayed by the previously prepared carborane ligand (4). The synthesis and preliminary DNA binding studies of these bibenzimidazole derivatives are presented herein.

scholarly journals Trabectedin – the DNA minor groove binder

2015 ◽  
Vol 2 (2) ◽  
pp. 41
Author(s):  
G. A. Belitsky ◽  
K. I. Kirsanov ◽  
E. A. Lesovaya ◽  
M. G. Yakubovskaya
Keyword(s):  
Minor Groove ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
Dna Minor Groove Binder

Inhibition of the in vitro integration of moloney murine leukemia virus DNA by the DNA minor groove binder netropsin

1994 ◽  
Vol 47 (10) ◽  
pp. 1821-1826 ◽  
Author(s):  
Sandrine Carteau ◽  
Jean Francois Mouscadet ◽  
Hélène Goulaouic ◽  
Frédéric Subra ◽  
Christian Auclair
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Minor Groove ◽  
Moloney Murine Leukemia Virus ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
Murine Leukemia ◽  
Dna Minor Groove Binder

Design, Synthesis, and Biological Activity of Hybrid Compounds between Uramustine and DNA Minor Groove Binder Distamycin A

2002 ◽  
Vol 45 (17) ◽  
pp. 3630-3638 ◽  
Author(s):  
Pier Giovanni Baraldi ◽  
Romeo Romagnoli ◽  
Antonio Entrena Guadix ◽  
Maria Josè Pineda de las Infantas ◽  
Miguel Angel Gallo ◽  
...  
Keyword(s):  
Biological Activity ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Design Synthesis ◽  
Distamycin A ◽  
Dna Minor Groove ◽  
Hybrid Compounds ◽  
Dna Minor Groove Binder

scholarly journals Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding

2014 ◽  
Vol 10 (10) ◽  
pp. 2724-2734 ◽  
Author(s):  
Jie Zhou ◽  
Vu Le ◽  
Dimpy Kalia ◽  
Shizuka Nakayama ◽  
Clinton Mikek ◽  
...  
Keyword(s):  
Dissociation Constant ◽  
Dissociation Constants ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
G Quadruplex ◽  
Dna Minor Groove Binder

Diminazene or berenil is known to be an AT-rich DNA minor groove binder with micromolar dissociation constant. Here, we show that DMZ binds to G-quadruplexes withKdas low as 1 nM.

scholarly journals Lurbinectedin (PM01183), a New DNA Minor Groove Binder, Inhibits Growth of Orthotopic Primary Graft of Cisplatin-Resistant Epithelial Ovarian Cancer

2012 ◽  
Vol 18 (19) ◽  
pp. 5399-5411 ◽  
Author(s):  
August Vidal ◽  
Clara Muñoz ◽  
María-José Guillén ◽  
Jemina Moretó ◽  
Sara Puertas ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
Dna Minor Groove Binder

RNase Activity of a DNA Minor Groove Binder with a Minimalist Catalytic Motif from RNase A

2001 ◽  
Vol 281 (5) ◽  
pp. 1283-1290 ◽  
Author(s):  
Mark Helm ◽  
Mary L. Kopka ◽  
Sanjay K. Sharma ◽  
J.William Lown ◽  
Richard Giegé
Keyword(s):  
Minor Groove ◽  
Rnase A ◽  
Rnase Activity ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
Catalytic Motif ◽  
Dna Minor Groove Binder

scholarly journals Diaminobenzene schiff base, a novel class of DNA minor groove binder

2012 ◽  
Vol 41 (2) ◽  
pp. 504-510 ◽  
Author(s):  
MUATH H. HELAL ◽  
ZENA A. AL-MUDARIS ◽  
MOHAMMED H. AL-DOUH ◽  
HASNAH OSMAN ◽  
HABIBAH A. WAHAB ◽  
...  
Keyword(s):  
Schiff Base ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
Dna Minor Groove Binder
Sign in / Sign up

Export Citation Format

Share Document