Embryonic signals and the initiation of blastocyst implanation.

TG Kennedy

doi:10.1071/bi9830531

Embryonic signals and the initiation of blastocyst implanation.

Australian Journal of Biological Sciences ◽

10.1071/bi9830531 ◽

1983 ◽

Vol 36 (6) ◽

pp. 531 ◽

Cited By ~ 59

Author(s):

TG Kennedy

Keyword(s):

Vascular Permeability ◽

Blastocyst Implantation

The earliest sign of blastocyst implantation is an increase in endometrial vascular permeability which is localized in areas adjacent to blastocysts. The localized nature of this response suggests that it occurs in response to a signal from the blastocyst. It has been suggested that this signal may be physical in nature, or may be due to blastocyst-produced histamine, oestrogen or prostaglandins. The evidence for each of these is reviewed. At present, it is not possible to exclude any of these signals, which are not mutually exclusive, with certainty. The bulk of the evidence suggests that prostaglandins have an obligatory role in the initiation of implantation, but they may not necessarily be of blastocyst origin.

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Prostaglandins and the initiation of blastocyst implantation and decidualization

Reproduction ◽

10.1530/rep-07-0328 ◽

2007 ◽

Vol 134 (5) ◽

pp. 635-643 ◽

Cited By ~ 95

Author(s):

Thomas G Kennedy ◽

Carolina Gillio-Meina ◽

Sen Han Phang

Keyword(s):

Vascular Permeability ◽

Trophoblast Invasion ◽

Considerable Evidence ◽

Blastocyst Implantation

The process of blastocyst implantation in mammals is remarkably variable, especially in the extent of trophoblast invasion of the endometrium. In most species studied, the earliest macroscopically identifiable sign of blastocyst implantation is an increase in endometrial vascular permeability in areas adjacent to the blastocysts. This is followed in species with invasive implantation by decidualization, again localized to areas adjacent to the blastocysts. In some species, the application of a stimulus to the endometrium can result in increased endometrial vascular permeability and decidualization. Based initially on studies utilizing inhibitors of prostaglandin (PG) synthesis and more recently on studies using the techniques of transgenics, considerable evidence has accumulated indicating that PGs have an important role in the early events of implantation and artificially induced decidualization. However, which PGs are involved remains controversial. There may be differences between species, and different PGs may be involved at different times.

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Aspects of increased vascular permeability following the intradermal injection of histamine in the rat

Pathology ◽

10.1080/00313027109073733 ◽

1971 ◽

Vol 3 (3) ◽

pp. 191-202 ◽

Cited By ~ 4

Author(s):

Arlie McQueen ◽

J.V. Hurley

Keyword(s):

Vascular Permeability ◽

Intradermal Injection

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Morphological features of endo- and myometrium in patients with uterine leiomyoma and infertility

HEALTH OF WOMAN ◽

10.15574/hw.2020.151-152.33 ◽

2020 ◽

pp. 33-37

Author(s):

M.A. Flaksenberg ◽

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Keyword(s):

Uterine Leiomyoma ◽

Negative Impact ◽

Reproductive Function ◽

Cell Types ◽

Underlying Disease ◽

Reproductive Organs ◽

Pathological Process ◽

Simple Type ◽

Morphological Examination ◽

Blastocyst Implantation

The objective: determination of morphofunctional features of leiomatous nodes and endometrium in women with uterine leiomyoma and infertility to restore reproductive function and prevent recurrence of the underlying disease. Materials and methods. In order to restore reproductive function and prevent recurrence of the underlying disease, morphofunctional features of leiomatous nodes and endometrium in women with uterine leiomyoma and infertility were determined. Thirty samples of leiomyomatous nodes and endometrium were examined, among which 15 were obtained from women with multiple uterine leiomyoma and infertility and 15 samples from women with uterine leiomyoma with isolated uterine leiomyoma. During the study, a general-histological method was used for staining with hematoxylin-eosin and picrofuxin by van Gizon, as well as immunohistochemical methods. Histological examination of the endometrium was performed according to conventional protocol, taking into account the day of the menstrual cycle and R.W. Noyes criteria. Results. In the morphological examination of leiomyomatous nodes in the vast majority of cases the presence of uterine leiomyomas of simple and cell types or their combination was established. In women with multiple uterine leiomyoma, simple-type leiomyoma (53.3%) was predominant, and in patients with isolated leiomyoma the signs of cellular uterine leiomyoma (66.7%) were more frequently found. In 80.0% of women with uterine leiomyoma revealed pathology of the endometrium, such as glandular and glandular-fibrous polyps, simple and complex atypical endometrial hyperplasia, which confirms the theory about the only pathogenetic mechanisms of the emergence of hyperplastic processes of female organs. In 66.7% of women with multiple leiomyomas, signs of chronic endometritis have been found, which exacerbates the pathological process and can have a negative impact on the reproductive function, such as secretory endometrial transformation and impaired blastocyst implantation, and explains a much higher percentage of infertility in the group. Conclusion. In women with impaired reproductive function, patients with uterine leiomyoma, it is necessary to conduct a study of the receptivity of the reproductive organs, namely - the endometrium and leiomatous nodes. This will make it possible to use one or another method of treatment in order to restore reproductive function and prevent recurrence of the underlying disease. Keywords: infertility, uterine leiomyoma, endometrium, receptive apparatus.

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