scholarly journals Diurnal Patterns of Plasma Insulin, Growth Hormone, Corticosteroid and Metabolite Concentrations in Fed and Fasted Sheep

1974 ◽  
Vol 27 (2) ◽  
pp. 167 ◽  
Author(s):  
JM Bassett
Keyword(s):  
Growth Hormone ◽  
Plasma Insulin ◽  
Plasma Concentrations ◽  
Diurnal Patterns ◽  
Metabolite Concentrations ◽  
Feeding Cycle ◽  
Normal Feeding

To determine the effects of feeding on plasma concentrations of insulin and growth hormone (GH) in sheep during the full 24 h of the normal feeding cycle, two experiments have been conducted on a group of 18 crossbred wethers.

RELATIONSHIP BETWEEN LAMB BIRTH WEIGHTS AND FETAL PLASMA GROWTH HORMONE AND INSULIN CONCENTRATIONS

1986 ◽  
Vol 66 (4) ◽  
pp. 995-1001
Author(s):  
G. J. MEARS
Keyword(s):  
Growth Hormone ◽  
Fetal Growth ◽  
Plasma Insulin ◽  
Plasma Concentrations ◽  
Maternal Plasma ◽  
Metabolic Clearance ◽  
Plasma Growth Hormone ◽  
Fetal Plasma ◽  
Plasma Gh ◽  
Ovine Fetal

Plasma concentrations of growth hormone (GH) and insulin were monitored in 11 chronically cannulated ovine fetuses and their mothers during the last month of gestation to obtain information on the role that these hormones have in determining fetal growth rate. Maternal plasma GH and insulin concentrations were independent of stage of gestation and lamb birth weights. Fetal plasma insulin concentrations were episodic in nature, independent of stage of gestation, and tended to be higher in fetuses that were heavier at birth. Fetal plasma GH concentrations were only slightly episodic in nature, were tenfold higher than maternal levels at 116–124 d gestation and increased by approximately another 25% prior to parturition. Fetal plasma GH concentrations were negtively correlated with lamb birth weights. In twin preparations, fetal plasma GH concentrations were significantly lower in the twin that was heaviest at birth. The lower GH concentrations found in faster growing fetuses are suggestive of a more rapid metabolic clearance of GH by the tissues of these animals. The results indicate that circulating fetal GH and, possibly, insulin are involved in determining the rate of ovine-fetal growth. Key words: Ovine birth weights, fetal GH, fetal insulin, fetal growth

scholarly journals The relationship between hormonal balance and growth in malnourished children and rats

1979 ◽  
Vol 41 (1) ◽  
pp. 73-84 ◽  
Author(s):  
P. G. Lunn ◽  
R. G. Whitehead ◽  
T. J. Cole ◽  
S. Austin
Keyword(s):  
Growth Hormone ◽  
Growth Velocity ◽  
Plasma Insulin ◽  
Animal Experiment ◽  
Plasma Concentrations ◽  
Hormonal Control ◽  
Malnourished Children ◽  
Hormonal Balance ◽  
Rates Of Growth ◽  
The Relationship

1. Plasma concentrations of insulin, cortisol and growth hormone, and growth velocities have been measured in a group of Gambian village children up to 3 years of age. All three hormones showed changes in concentration with age, as did rates of growth.2. Plasma insulin concentrations in the children were directly correlated with velocity of growth in height and weight, whereas cortisol concentrations showed inverse relationships. The values for insulin:cortisol concentration correlated more closely with growth velocity than did either hormone individually. Growth hormone values in plasma exhibited only marginal correlations with growth in height or weight, and these were negative.3. Similar relationships between these hormones and growth were obtained from an animal experiment in which the rates of growth of rats were altered by restricting dietary intake of protein or energy or both.4. Possible mechanisms for these observations are discussed in the light of recent knowledge concerning the hormonal control of growth rates.

Effects of pancreatectomy on the growth and metabolite concentrations of the sheep fetus

1986 ◽  
Vol 110 (2) ◽  
pp. 225-231 ◽  
Author(s):  
A. L. Fowden ◽  
X. Z. Mao ◽  
R. S. Comline
Keyword(s):  
Body Weight ◽  
Plasma Insulin ◽  
Plasma Concentrations ◽  
Amino Nitrogen ◽  
In Utero ◽  
The Body ◽  
Fetal Sheep ◽  
Crown Rump Length ◽  
Metabolite Concentrations ◽  
Near Term

ABSTRACT The effects of fetal pancreatectomy on the growth and metabolism of the fetal sheep were investigated in chronically catheterized animals during the last third of gestation. Fetal pancreatectomy reduced body weight and crown–rump length at delivery near term (term 145 days). Body weight was affected more than body length so the ratio of weight to length was significantly less after pancreatectomy than in intact animals (P < 0·05). Pancreatectomized fetuses appeared to maintain a normal growth rate for 5–10 days after surgery but thereafter showed no further significant increase in body weight. When all the data from the intact and pancreatectomized fetuses were combined, there was a significant positive correlation between the plasma insulin concentration in utero and the body weight at delivery near term. The majority of organs studied were reduced in absolute weight after pancreatectomy but only the spleen and thymus were proportionally lighter when the weights were expressed as a percentage of body weight. Brain and placental weights were similar in intact and pancreatectomized fetuses. Over the range of values observed in utero, there were significant inverse correlations between the log plasma insulin level and the mean plasma concentrations of glucose, lactate, fructose and α-amino-nitrogen in individual intact and pancreatectomized fetuses. Insulin infusion into pancreatectomized fetuses restored the metabolite concentrations to their normal values within 48 h of infusion. The results demonstrate that insulin has a vital role in regulating fetal growth and metabolism in utero. J. Endocr. (1986) 110, 225–231

Influence of feeding and diet on diurnal patterns of plasma growth hormone and insulin in calves

1993 ◽  
Vol 73 (4) ◽  
pp. 987-991 ◽  
Author(s):  
G. J. Mears
Keyword(s):  
Growth Hormone ◽  
Plasma Insulin ◽  
Feeding Time ◽  
Elevated Plasma ◽  
Plasma Growth Hormone ◽  
Diurnal Patterns ◽  
Newborn Calves ◽  
Meal Feeding ◽  
Plasma Gh ◽  
Diet Type

Plasma GH concentrations were lower after feeding than before (newborn calves, P < 0.05; steers, P < 0.01). Calves fed concentrate had higher plasma insulin concentrations than those fed hay (P < 0.01). Meal feeding milk or concentrate, but not hay, elevated plasma insulin (P < 0.05). Diet type and feeding time relative to sampling time must be considered when measuring GH and insulin. Key words: Diurnal patterns, growth hormone, GH, insulin, calves

THE EFFECT OF THE PROGESTOGEN ETHYNODIOL DIACETATE ON GLUCOSE, INSULIN, AND GROWTH HORMONE AFTER SIX MONTHS TREATMENT

1972 ◽  
Vol 70 (2) ◽  
pp. 373-384 ◽  
Author(s):  
W. N. Spellacy ◽  
W. C. Buhi ◽  
S. A. Birk
Keyword(s):  
Growth Hormone ◽  
Blood Glucose ◽  
Plasma Insulin ◽  
Tolerance Test ◽  
Metabolic Effects ◽  
Oral Glucose ◽  
Hormone Levels ◽  
Glucose Levels ◽  
Ethynodiol Diacetate ◽  
Tolerance Curve

ABSTRACT Seventy-one women were treated with a daily dose of 0.25 mg of the progestogen ethynodiol diacetate. They were all tested with a three-hour oral glucose tolerance test before beginning the steroid and then again during the sixth month of use. Measurements were made of blood glucose and plasma insulin and growth hormone levels. There was a significant elevation of the blood glucose levels after steroid treatment as well as a deterioration in the tolerance curve in 12.9% of the women. The plasma insulin values were also elevated after drug treatment whereas the fasting ambulatory growth hormone levels did not significantly change. There was a significant association between the changes in glucose and insulin levels and the subject's age, control weight, or weight gain during treatment. The importance of considering the metabolic effects of the progestogen component of oral contraceptives is stressed.

scholarly journals Diurnal Variation in Glucose Tolerance: Associated Changes in Plasma Insulin, Growth Hormone, and Non-esterified

BMJ ◽  
1974 ◽  
Vol 1 (5906) ◽  
pp. 485-488 ◽  
Author(s):  
P. Z. Zimmet ◽  
J. R. Wall ◽  
R. Rome ◽  
L. Stimmler ◽  
R. J. Jarrett
Keyword(s):  
Growth Hormone ◽  
Glucose Tolerance ◽  
Diurnal Variation ◽  
Plasma Insulin

scholarly journals Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting

1997 ◽  
Vol 273 (1) ◽  
pp. R113-R120 ◽  
Author(s):  
B. Ahren ◽  
S. Mansson ◽  
R. L. Gingerich ◽  
P. J. Havel
Keyword(s):  
Body Weight ◽  
Dietary Fat ◽  
High Fat Diet ◽  
Plasma Insulin ◽  
Plasma Concentrations ◽  
Age Groups ◽  
Fat Content ◽  
High Fat ◽  
Background Strain ◽  
Plasma Leptin

Mechanisms regulating circulating leptin are incompletely understood. We developed a radioimmunoassay for mouse leptin to examine the influence of age, dietary fat content, and fasting on plasma concentrations of leptin in the background strain for the ob/ob mouse, the C57BL/6J mouse. Plasma leptin increased with age [5.3 +/- 0.6 ng/ml at 2 mo (n = 23) vs. 14.2 +/- 1.6 ng/ml at 11 mo (n = 15), P < 0.001]. Across all age groups (2-11 mo, n = 160), log plasma leptin correlated with body weight (r = 0.68, P < 0.0001), plasma insulin (r = 0.38, P < 0.001), and amount of intra-abdominal fat (r = 0.90, P < 0.001), as revealed by magnetic resonance imaging. Plasma leptin was increased by a high-fat diet (58% fat for 10 mo) and reduced by fasting for 48 h. The reduction of plasma leptin was correlated with the reduction of plasma insulin (r = 0.43, P = 0.012) but not with the initial body weight or the change in body weight. Moreover, the reduction in plasma leptin by fasting was impaired by high-fat diet. Thus plasma leptin in C57BL/6J mice 1) increases with age or a high-fat diet; 2) correlates with body weight, fat content, and plasma insulin; and 3) is reduced during fasting by an action inhibited by high-fat diet and related to changes of plasma insulin.

Sign in / Sign up

Export Citation Format

Share Document