scholarly journals Effect of Colchicine on pre-Implantation Blastocysts and Io-Day-Old Embryos of the Golden Hamster

1972 ◽  
Vol 25 (5) ◽  
pp. 1105
Author(s):  
M Sohrab
Keyword(s):  
Body Weight ◽  
Effective Dose ◽  
Golden Hamster ◽  
Guinea Pigs ◽  
Natural Resistance ◽  
Normal Number ◽  
Lethal Level ◽  
Normal Ratio ◽  
Effective Doses

Orsini and Panski (1952) used colchicine in their investigations on the pro-liferative growth of hamster tissue. They found that injected doses of colchicine varying from O� 1 up to 2 mg per 100 g body weight did not cause any significant v4riation from the normal number of mitoses, and the presence of anaphase and telo-phase stages with normal spindles in normal ratio suggested that these doses were ineffective. They stated that effective doses in other rodents (mice, rats, guinea-pigs, and rabbits) are usually below the lethal level. In an attempt to establish the effective dose, they injected colchicine intraperitoneally at concentrations ranging from 0�13 to 7 mg per 100 g body weight into a series of hamsters, rats, mice, and a rabbit. At these levels colchicine was lethal for the latter three series of animals, but was not lethal for hamsters, even up to a concentration of 10 mg per 100 g body weight. They concluded that the hamster possesses a natural resistance to this compound.

MEASUREMENT OF THE ACTIVITY CONCENTRATIONS OF GAMMA EMITTING RADIONUCLIDES IN TOOTHPASTE SAMPLES AND ASSESSMENT OF THE CORRESPONDING ANNUAL EFFECTIVE DOSES

2021 ◽  
Author(s):  
Anas M Ababneh ◽  
Qutad M Samarah
Keyword(s):  
Effective Dose ◽  
Oral Hygiene ◽  
Annual Effective Dose ◽  
Daily Basis ◽  
Dose Assessment ◽  
Accidental Ingestion ◽  
Activity Concentrations ◽  
Effective Doses

Abstract It is inevitable that we are exposed to radiation daily from various sources and products that we consume on daily basis. The use of toothpaste for oral hygiene is one of the most common daily practices by humans and yet very little data are available regarding its radiation content. In this work, we investigated the concentrations of gamma emitting radionuclides in toothpaste samples consumed in Jordan. 40K and 226Ra were detected in almost one-third of the samples, whereas 228Ra was detected in nearly half of them. The corresponding activity concentrations in the detected samples were in the ranges of 68.7–154.2, 4.6–14.1 and 1.3–10.0 Bq/kg, respectively. Dose assessment of accidental ingestion of toothpaste for children and adults was made, and its contribution to the annual effective dose was found to be very minimal with maximum doses of ~2.9 and 1.3 μSv for children and adults, respectively.

DOSAGE OF DRUGS IN INFANTS AND CHILDREN: III. NEOSTIGMINE

PEDIATRICS ◽  
1956 ◽  
Vol 18 (1) ◽  
pp. 31-38
Author(s):  
Paul R. Patterson ◽  
Earle L. Lipton ◽  
Klaus R. Unna ◽  
Kurt Glaser
Keyword(s):  
Body Weight ◽  
Gastrointestinal Motility ◽  
Age Groups ◽  
Sweat Glands ◽  
Healthy Children ◽  
Controlled Experiments ◽  
Hypodermic Injection ◽  
Effective Doses ◽  
In Infants And Children ◽  
Stimulation Of

The susceptibility of healthy children to neostigmine by hypodermic injection was studied in controlled experiments on 45 children ranging in age from 1 month to 12 years. Minimum effective doses (MED) of neostigmine were determined by their effect in stimulating salivary and sweat glands, and in increasing gastrointestinal motility. The MED of neostigmine for stimulation of salivation is in all age groups smaller (by 6 to 38 per cent) than the MED increasing gastrointestinal motility. The average MED either for glandular (.025 to .036 mg./kg.) or gastrointestinal (.036 to .045 mg./kg.) activity fails to show significant differences among the various age groups when expressed in terms of body weight. Exceptions were found exclusively in children weighing more than 30 kg. The findings do not support the view that a physiologic vagotonia is present in infants.

The effects of furosemide and bumetanide on lung liquid production by in vitro lungs from fetal guinea pigs

1990 ◽  
Vol 68 (8) ◽  
pp. 1131-1135 ◽  
Author(s):  
J. Thom ◽  
A. M. Perks
Keyword(s):  
Body Weight ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Loop Diuretics ◽  
Dilution Technique ◽  
Blue Dextran ◽  
Lung Fluid ◽  
Lung Liquid ◽  
Secretion Rates

Lungs from fetal guinea pigs of 61 ± 3 days of gestation were supported in vitro for 3 h, and lung liquid secretion rates were measured by a dye dilution technique based on Blue Dextran 2000. Ten preparations that had received no treatment showed an average secretion rate of 1.12 ± 0.28 mL∙kg−1 body weight∙h−1 during the first hour, and there were no significant changes over the following 2 h. In studies of 54 fetal lungs, furosemide, bumetanide, control ethanol carrier, or saline alone were placed in the supporting medium during the middle hour of the 3-h incubations (ABA design). Furosemide at 10−3 M reduced secretion 83.4 ± 16.8%; at 10−4 and 10−5 M it produced smaller reductions. Bumetanide at 10−3 M usually produced reabsorption (129.9 ± 23.0% reduction), at 10−4 M it reduced secretion 30.9 ± 11.8%, but at 10−5 M it was ineffective. Control carrier and saline were without effect. The ability of the loop diuretics to produce reabsorption of fluid in some preparations suggests the unmasking of an active reabsorptive process. The results also suggest that lung liquid secretion in the fetal guinea pig, as in the sheep, is dependent on a Na+ and Cl− cotransport system.Key words: fetus, lung fluid, bumetanide, furosemide.

scholarly journals THE USE OF BIOSTIMULANT FOR INCREASING THE BODY WEIGHT GAIN OF CHICKENS

2020 ◽  
Vol 17 (35) ◽  
pp. 800-812
Author(s):  
Ilgiz DOLININ ◽  
George BAZEKIN ◽  
Evgeny SKOVORODIN ◽  
Almaz SHARIPOV ◽  
Ivan CHUDOV
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
Live Weight ◽  
The Body ◽  
New Drugs ◽  
Natural Resistance ◽  
Control Group ◽  
Immunological Parameters

Poultry farming holds a special place in ensuring the products that the consumers demand, it provides the population with essential food products,such as eggs and meat,that contain vital micro and macronutrients, proteins, lipids, and vitamins. Therefore, the issues of rational, economically feasible feeding of meat poultry, namely broiler chickens, are an urgent task. It is also essential to find effective methods of their application in order to correct the natural resistance and immune and biological reactivity of birds. The purpose of this research is to study the effect of the biological stimulant-Nucleostim on the growth and development of chickens, hematological, and immunological parameters of the blood of birds.This Biostimulant is a purified bovine spleen extract containing at least 1 mg / ml of low molecular weight peptides (nucleotides and nucleosides) formed as a result of autolysis, using dry whey and diatomite as fillers. Onthe application ofNucleostim, the gain in live weight of chickens was increased by 9.7%. At the end of the experiment, the livability of the chicks of the experimental group treated with Nucleostimcame up to 88%, compared with the 72% of the control group. The use of biostimulant had a stimulating effect on the liver of chickens confirmed by the research results presented in the article, as well as contributed to the development of the thymus in the setting of general dystrophy. Thus, it improved chicklivability and increased body weight gain. The biological stimulant-Nucleostim as an adaptogenic, anabolic, and immunostimulatory agent is promising for finding new drugs that improve the health and productivity of poultry.

scholarly journals Reproductive Characteristics, Serum Metabolites, and Oxidative Status in Female Guinea Pigs (Cavia porcellus) Fed with Ethanolic Extract of Dichrostachys glomerata Fruit

2021 ◽  
Vol 11 (1) ◽  
pp. 66-72
Author(s):  
Nadège Motchewo Djuissi ◽  
Ferdinand Ngoula ◽  
Justin Kouamo ◽  
Narcisse Bertin Vemo ◽  
Mathieu Fambo Stive Nono ◽  
...  
Keyword(s):  
Body Weight ◽  
Guinea Pigs ◽  
Ethanolic Extract ◽  
Oxidative Status ◽  
The Body ◽  
Control Group ◽  
Cavia Porcellus ◽  
Crown Rump Length ◽  
Serum Metabolites ◽  
Reproductive Characteristics

Dichrostachys glomerata (D. glomerata) is an aromatic plant which is used as a spice in cooking and Cameroonian traditional medicine to treat infertility in men. This work was designed to highlight the effects of the ethanolic extract of D. glomerata on oxidative status, serum metabolites and reproductive characteristics in female guinea pigs (Cavia porcellus). A total of 48 primiparous female guinea pigs, aged 4 months old with the body weight of 400 ± 10 g, were divided into four groups with two replications per group (6 guinea pigs each). During 90 days of trial, Group 1 (control group) orally received 1 ml/kg b.w. of distilled water daily, and groups 2, 3, and 4 received D. glomerata ethanolic extract once a day at doses of 50, 100, and 200 mg/kg b.w. using the same method of administration, respectively, for 90 days, including 60 days of gestation. After the first 30 days of treatment, mating was done by placing one non-treated male into cages containing six treated females. At the end of the treatment, data were collected on reproductive characteristics, serum metabolites, and oxidative stress markers. The results revealed that the ethanolic extract of D. glomerata induced a significant decrease in the number of post-implantation resorption and ovaries weight. Groups 3 and 4 showed a significant increase in the number of fetuses per dam and viable fetuses as well as placenta weight, compared to the control group. The serum level of progesterone significantly decreased in the group treated with 200 mg/kg D. Glomerata, compared to the other treated groups. The extract at 100 mg/kg body weight showed a significant increase in fetuses weight and fetuses crown-rump length, compared to the control group. Catalase activity significantly increased in the control group than D. glomerata treated groups. In conclusion, ethanolic extract of D. glomerata minimized reproductive stress and subsequently improved the reproductive performance of guinea pigs.

scholarly journals Specific Activities of Natural Radionuclides and Annual Effective Dose Due to the Intake of Some Types of Children Powdered Milk Available in Baghdad Markets

2017 ◽  
Vol 14 (3) ◽  
pp. 619-624
Author(s):  
Baghdad Science Journal
Keyword(s):  
Effective Dose ◽  
Sodium Iodide ◽  
Specific Activity ◽  
Annual Effective Dose ◽  
Natural Radionuclides ◽  
Mean Value ◽  
Powdered Milk ◽  
Effective Doses ◽  
The Mean ◽  
Specific Activities

In this research the specific activity of natural radionuclides 226Ra, 232Th and 40K were determined by sodium iodide enhanced by thallium NaI(TI) detector and assessed the annual effective dose in Dielac 1 and 2 and Nactalia 1 and 2 for children of less than 1 year which are available in Baghdad markets. The specific activity of 40K has the greater value in all the types which is in the range of allowed levels globally that suggested by UNSCEAR. The mean value of annual effective doses were 2.92, 4.005 and 1.6325 mSv/y for 226Ra, 232Th and 40K respectively.

CONTEMPORARY COLLECTIVE EFFECTIVE DOSE TO THE POPULATION FROM X-RAY AND NUCLEAR MEDICINE EXAMINATIONS—CHANGES OVER LAST 10 YEARS IN FINLAND

2020 ◽  
Vol 189 (3) ◽  
pp. 318-322
Author(s):  
Ritva Bly ◽  
Hannu Järvinen ◽  
Sampsa Kaijaluoto ◽  
Verneri Ruonala
Keyword(s):  
Nuclear Medicine ◽  
Effective Dose ◽  
Plain Radiography ◽  
Conversion Factors ◽  
X Ray ◽  
Weighting Factors ◽  
Effective Doses

Abstract Contemporary collective effective doses to the population from x-ray and nuclear medicine examinations in Finland in 2018 was estimated. The estimated effective dose per caput from x-ray examinations increased from year 2008 to 2018 respectively from 0.45 mSv to 0.72 mSv and from nuclear medicine examinations from 0.03 mSv to 0.04 mSv. The proportional dose due to CT examinations of the total collective effective dose from all x-ray examinations increased from 58% in 2008 to 70% in 2018 and the dose did not change substantially in total when new conversion factors were applied. The collective effective dose from conventional plain radiography did not change substantially during the last ten years while the new (ICRP 103) tissue weighting factors were taken into use in 2018, however frequencies of examinations in total decreased. The collective effective dose from CT in nuclear medicine tripled between 2009 and 2018.

EFFECT OF HISTAMINE ON GASTRIC PEPSINOGEN, PEPSIN SECRETION, AND BLOOD PEPSINOGEN IN GUINEA PIGS

1957 ◽  
Vol 35 (1) ◽  
pp. 729-732
Author(s):  
K. Kowalewski
Keyword(s):  
Body Weight ◽  
Gastric Mucosa ◽  
Guinea Pig ◽  
Gastric Juice ◽  
Guinea Pigs ◽  
Gastric Tissue ◽  
Pepsin Secretion ◽  
Enzymatic Function ◽  
Guinea Pig Stomach

The endocrine and exocrine activity of guinea pig stomach was measured by the determination of pepsinogen in gastric tissue and in plasma. Gastric juice pepsin was also studied.A significant increase of both pepsinogen and pepsin was found in animals treated with a dose of histamine (75 mg. per kg. of body weight). These results give further evidence that the zymogenic cells of gastric mucosa may be stimulated by histamine. The determination of pepsinogen in gastric tissue seems to permit a direct approach to the enzymatic function of zymogenic cells.

RESULTS OF CZECH NATIONAL STUDY OF RADIATION EXPOSURE FROM RADIOTHERAPY OF NON-MALIGNANT DISEASES, IN PARTICULAR OF HEEL SPURS

2019 ◽  
Vol 186 (2-3) ◽  
pp. 386-390
Author(s):  
V Dufek ◽  
H Zackova ◽  
L Kotik ◽  
I Horakova
Keyword(s):  
Czech Republic ◽  
Clinical Practice ◽  
Radiation Exposure ◽  
Effective Dose ◽  
National Study ◽  
Malignant Diseases ◽  
Organ Doses ◽  
The Czech Republic ◽  
X Ray ◽  
Effective Doses

Abstract About 26 000 patients are treated per year with radiotherapy for non-malignant diseases in the Czech Republic. Approximately 75% of them are treated on X-ray therapy units and most of these patients undergo radiotherapy of heel spurs. The evaluation of radiation exposure of these patients was based on measured organ doses and on data from clinical practice. Collective effective doses for particular diagnoses were calculated in order to compare doses resulting from different diagnoses treated on X-ray therapy units. The collective effective dose from radiotherapy of heel spurs in the Czech Republic in 2013 was evaluated to 77 manSv. It represents 25.6% of the total collective effective dose for all diagnoses of radiotherapy for non-malignant diseases treated on X-ray therapy units.

OVERVIEW OF AIRCREW EXPOSURE TO COSMIC RADIATION IN THE CZECH REPUBLIC

2019 ◽  
Vol 186 (2-3) ◽  
pp. 211-214
Author(s):  
Ján Kubančák ◽  
Dagmar Kyselová ◽  
Ivan Kovář ◽  
Magdaléna Hlaváčová ◽  
Ronald Langer ◽  
...  
Keyword(s):  
Czech Republic ◽  
Effective Dose ◽  
Cosmic Radiation ◽  
Computer Code ◽  
Crew Member ◽  
Relative Uncertainty ◽  
The Czech Republic ◽  
Effective Doses ◽  
The Individual

Abstract Monitoring of exposures of aircrew members of airline operators registered in the Czech Republic has been performed since 1998. The individual effective doses are calculated using the computer code CARI annually. The calculations are based on information about participation of aircrew members on the specific flights and on the parameters describing the typical flight profiles of the flights; the latter is regularly verified with control measurements performed onboard aircraft. The results show that (1) the average annual effective doses in the period from 1998 to 2017 range from 1.3 to 2.1 mSv, (2) the maximum effective dose of a crew member is 5.7 mSv and (3) the annual collective effective doses range from 1.3 to 4.1 manSv. Combined relative uncertainty of the results is ~25%.

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