scholarly journals Effects of Exogenous Moulting Hormones on Puparium Formation in Calliphora

1969 ◽  
Vol 22 (3) ◽  
pp. 761 ◽  
Author(s):  
JA Thomson ◽  
DHS Horn
Keyword(s):  
Biological Activity ◽  
Mode Of Action ◽  
Cellular Level ◽  
Hormone Activity ◽  
Puparium Formation ◽  
Moulting Hormone ◽  
Moulting Hormones

Pupal sclerotization in holometabolous insects has been widely used as a basis for bioassays of moulting hormone activity (for review see Horn 1969), anJ there has been considerable interest in the mode of action of these hormones at the cellular level (Karlson and Sekeris 1966). It is surprising that the effects of exogenous moulting hormone on the time and mode of puparium formation in the intact dipteran larva have seldom been reported (except e.g. Fourche 1967, on Dro8ophila), especially in view of interest in the relative biological activity of the various ecdysone-group steroids in stimulating sclerotization (Ohtaki, Milkman, and Williams 1967).

Biological activity of synthetic moulting hormone analogues in the blowflyCalliphora stygia

1973 ◽  
Vol 29 (1) ◽  
pp. 19-19 ◽  
Author(s):  
M. N. Galbraith ◽  
D. H. S. Horn ◽  
E. J. Middleton ◽  
J. A. Thomson
Keyword(s):  
Biological Activity ◽  
Moulting Hormone

BIOCHEMICAL MECHANISMS OF HORMONE ACTION

1966 ◽  
Vol 53 (3) ◽  
pp. 505-518 ◽  
Author(s):  
P. Karlson ◽  
C. E. Sekeris
Keyword(s):  
Mode Of Action ◽  
Messenger Rna ◽  
Gene Activation ◽  
Enzyme Synthesis ◽  
Active Enzyme ◽  
Hormone Action ◽  
Reaction Sequence ◽  
Allosteric Effectors ◽  
Biochemical Mechanisms ◽  
Moulting Hormone

ABSTRACT Some recent hypotheses on the mode of action of hormones are reviewed. One concept, arising from experiments with artificially cleaved ribonuclease, namely that hormones may »complete« some proteins to form an active enzyme, is regarded as unlikely. Moreover, the idea that hormones act as »allosteric effectors« of enzymes is not well substantiated. A third hypothesis, i. e. that hormones may act as gene activators, is discussed at some length. Gene activation would lead to production of messenger-RNA and induced enzyme synthesis. For ecdysone, the moulting hormone of insects, every step of this reaction sequence has been demonstrated experimentally.

scholarly journals Thiol-Modification as Important Mode of Action for Allicin from Garlic (Allium sativum)

Proceedings ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 27 ◽  
Author(s):  
Martin C. H. Gruhlke
Keyword(s):  
Molecular Weight ◽  
Biological Activity ◽  
Active Compound ◽  
Mode Of Action ◽  
Allium Sativum ◽  
Cysteine Residues ◽  
Low Molecular Weight ◽  
Thiol Groups ◽  
Ancient Times ◽  
In Cells

Garlic is a common ingredient in food, normally used as spice but is also used since ancient times for its health beneficial activity. The thiosulfinate allicin is the first active compound in freshly damaged garlic tissue and reacts with thiol-groups. Hence, allicin is able to modify thiol groups, both of protein cysteine-residues and low-molecular weight thiols like glutathione. This thiol-modification is supposed to be an important mechanism for allicin’s biological activity. Here, the mechanisms and possible targets for allicin in cells are discussed.

GROWTH HORMONE ACTIVITY IN MAN OF CHYMOTRYPTIC DIGESTS OF BOVINE GROWTH HORMONE

1969 ◽  
Vol 44 (2) ◽  
pp. 255-265 ◽  
Author(s):  
M. SONENBERG ◽  
J. M. DELLACHA ◽  
C. A. FREE ◽  
A. C. NADLER
Keyword(s):  
Diabetes Mellitus ◽  
Growth Hormone ◽  
Biological Activity ◽  
Insulin Response ◽  
Complete Loss ◽  
Bovine Growth Hormone ◽  
Hormone Activity ◽  
Disk Electrophoresis ◽  
Hydrolysis Of ◽  
Electrophoretic Component

SUMMARY Bovine growth hormone (BGH) digested with chymotrypsin showed a significant retention of biological activity after the hydrolysis of six bonds and the formation of 20% non-precipitable nitrogen. Disk electrophoresis of ½ and 3 hr. digests demonstrated complete loss of the major electrophoretic component of BGH with the appearance of one or more components of greater anodal mobility. Administration of the chymotryptic digests of BGH to three hypopituitary patients resulted in an anti-insulin response, aggravation of diabetes mellitus or anabolic effects.

The moulting hormone activity of ponasterones in the Calliphora test

1968 ◽  
Vol 14 (1) ◽  
pp. 53-54 ◽  
Author(s):  
H. Hoffmeister ◽  
K. Nakanishi ◽  
M. Koreeda ◽  
H.Y. Hsu
Keyword(s):  
Hormone Activity ◽  
Moulting Hormone
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