scholarly journals Inheritance of Antibody Response

1955 ◽  
Vol 8 (4) ◽  
pp. 603 ◽  
Author(s):  
WR Sobey ◽  
KM Adams
Keyword(s):  
Antibody Response ◽  
Environmental Variation ◽  
Red Cells ◽  
Sheep Red Cells ◽  
Error Of Measurement

The heritability of antibody response to sheep red cells (S.R.C.) was found to be 0�2836 � 0�1475 at 3 days and 0�1097 � 0�1165 at 6 days. These estimates are subject to environmental variation of measurement which was found subsequently but could not be corrected for. An example of non-genetic, nonenvironmental error of measurement is illustrated experimentally and the consequences of this type of error are discussed.

A NON-SPECIFIC DEPRESSANT EFFECT ON THE IMMUNOLOGICAL RESPONSE

1962 ◽  
Vol 40 (10) ◽  
pp. 1353-1358
Author(s):  
Robert Bruce ◽  
Bernhard Cinader ◽  
John Percy
Keyword(s):  
Amino Acids ◽  
Antibody Response ◽  
Immunological Response ◽  
Red Cells ◽  
Depressant Effect ◽  
Intraperitoneal Route ◽  
Sheep Red Cells

The antibody response of mice to intraperitoneally injected sheep red cells was found to be markedly depressed by the injection of isogenic mouse red cells (1,2) given 1–3 days before the antigen. If the isogenic cells were administered at the same time or 1 day after the antigen, the antibody response was not affected. Other non-antigenic substances such as a 5% solution of amino acids exercised a similar depressant effect. The depression of the antibody response did not occur when the isogenic red cells were given intraperitoneally and the antigen by another route. When the effect of specific cells or agents on the antibody response is to be examined it is frequently necessary to make two injections. Only one of the two should be made by the intraperitoneal route.

A NON-SPECIFIC DEPRESSANT EFFECT ON THE IMMUNOLOGICAL RESPONSE

1962 ◽  
Vol 40 (1) ◽  
pp. 1353-1358
Author(s):  
Robert Bruce ◽  
Bernhard Cinader ◽  
John Percy
Keyword(s):  
Amino Acids ◽  
Antibody Response ◽  
Immunological Response ◽  
Red Cells ◽  
Depressant Effect ◽  
Intraperitoneal Route ◽  
Sheep Red Cells

The antibody response of mice to intraperitoneally injected sheep red cells was found to be markedly depressed by the injection of isogenic mouse red cells (1,2) given 1–3 days before the antigen. If the isogenic cells were administered at the same time or 1 day after the antigen, the antibody response was not affected. Other non-antigenic substances such as a 5% solution of amino acids exercised a similar depressant effect. The depression of the antibody response did not occur when the isogenic red cells were given intraperitoneally and the antigen by another route. When the effect of specific cells or agents on the antibody response is to be examined it is frequently necessary to make two injections. Only one of the two should be made by the intraperitoneal route.

scholarly journals Inheritance of Antibody Response III. Heritability of Response to Sheep Red Cells

1957 ◽  
Vol 10 (3) ◽  
pp. 367 ◽  
Author(s):  
PJ Claringbold ◽  
WR Sobey ◽  
KM Adams
Keyword(s):  
Antibody Response ◽  
Red Cells ◽  
Sheep Red Cells ◽  
Secondary Dose

The heritability of antibody response to a prunmg dose of sheep red cells is 41�8 � 19�4 per cent. and to a secondary dose-7'4 � 20�7 per cent.

Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells

1975 ◽  
Vol 5 (1) ◽  
pp. 70-72 ◽  
Author(s):  
M. Ferrarini ◽  
L. Moretta ◽  
Roberte Abrile ◽  
Maria Laura Durnte
Keyword(s):  
Human Lymphocytes ◽  
Red Cells ◽  
Sheep Red Cells

scholarly journals CELLS INVOLVED IN THE IMMUNE RESPONSE

1969 ◽  
Vol 129 (4) ◽  
pp. 757-774 ◽  
Author(s):  
Nabih I. Abdou ◽  
Maxwell Richter
Keyword(s):  
Bone Marrow ◽  
Immune Response ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Bone Marrow Cells ◽  
Allogeneic Bone Marrow ◽  
Red Cells ◽  
Allogeneic Bone ◽  
Sheep Red Blood Cells ◽  
Sheep Red Cells

Irradiated rabbits given allogeneic bone marrow cells from normal adult donors responded to an injection of sheep red blood cells by forming circulating antibodies. Their spleen cells were also capable of forming many plaques using the hemolysis in gel technique, and were also capable of undergoing blastogenesis and mitosis and of incorporating tritiated thymidine upon exposure to the specific antigen in vitro. However, irradiated rabbits injected with allogeneic bone marrow obtained from rabbits injected with sheep red blood cells 24 hr prior to sacrifice (primed donors) were incapable of mounting an immune response after stimulation with sheep red cells. This loss of reactivity by the bone marrow from primed donors is specific for the antigen injected, since the immune response of the irradiated recipients to a non-cross-reacting antigen, the horse red blood cell, is unimpaired. Treatment of the bone marrow donors with high-titered specific antiserum to sheep red cells for 24 hr prior to sacrifice did not result in any diminished ability of their bone marrow cells to transfer antibody-forming capacity to sheep red blood cells. The significance of these results, with respect to the origin of the antigen-reactive and antibody-forming cells in the rabbit, is discussed.

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