scholarly journals Tracing shallow lateral preferential pathways of fluid movement using electrical geophysics

2018 ◽  
Vol 2018 (1) ◽  
pp. 1-9
Author(s):  
Anthony Finn ◽  
Dr Mark Lackie
Keyword(s):  
Fluid Movement ◽  
Preferential Pathways ◽  
Electrical Geophysics

scholarly journals The Effect of Fluid Flow Shear Stress and Substrate Stiffness on Yes-Associated Protein (YAP) Activity and Osteogenesis in Murine Osteosarcoma Cells

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3128
Author(s):  
Thomas R. Coughlin ◽  
Ali Sana ◽  
Kevin Voss ◽  
Abhilash Gadi ◽  
Upal Basu-Roy ◽  
...  
Keyword(s):  
Shear Stress ◽  
Fluid Flow ◽  
Bone Cells ◽  
Bone Cancer ◽  
Substrate Stiffness ◽  
Flow Shear ◽  
Fluid Movement ◽  
Flow Shear Stress ◽  
Fluid Flow Shear Stress ◽  
New Treatments

Osteosarcoma (OS) is an aggressive bone cancer originating in the mesenchymal lineage. Prognosis for metastatic disease is poor, with a mortality rate of approximately 40%; OS is an aggressive disease for which new treatments are needed. All bone cells are sensitive to their mechanical/physical surroundings and changes in these surroundings can affect their behavior. However, it is not well understood how OS cells specifically respond to fluid movement, or substrate stiffness—two stimuli of relevance in the tumor microenvironment. We used cells from spontaneous OS tumors in a mouse engineered to have a bone-specific knockout of pRb-1 and p53 in the osteoblast lineage. We silenced Sox2 (which regulates YAP) and tested the effect of fluid flow shear stress (FFSS) and substrate stiffness on YAP expression/activity—which was significantly reduced by loss of Sox2, but that effect was reversed by FFSS but not by substrate stiffness. Osteogenic gene expression was also reduced in the absence of Sox2 but again this was reversed by FFSS and remained largely unaffected by substrate stiffness. Thus we described the effect of two distinct stimuli on the mechanosensory and osteogenic profiles of OS cells. Taken together, these data suggest that modulation of fluid movement through, or stiffness levels within, OS tumors could represent a novel consideration in the development of new treatments to prevent their progression.

scholarly journals Fluid Movement in Occluded Single Capillaries of Rabbit Omentum

1971 ◽  
Vol 28 (3) ◽  
pp. 358-366 ◽  
Author(s):  
J. S. LEE ◽  
L. H. SMAJE ◽  
B. W. ZWEIFACH
Keyword(s):  
Fluid Movement

scholarly journals Modelling of localised gas preferential pathways in claystone

2014 ◽  
Vol 67 ◽  
pp. 104-114 ◽  
Author(s):  
Pierre Gerard ◽  
Jon Harrington ◽  
Robert Charlier ◽  
Frédéric Collin
Keyword(s):  
Preferential Pathways

scholarly journals Evidence of Preferential Flow Activation in the Vadose Zone via Geophysical Monitoring

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1358
Author(s):  
Lorenzo De Carlo ◽  
Kimberlie Perkins ◽  
Maria Clementina Caputo
Keyword(s):  
Preferential Flow ◽  
Water Movement ◽  
Test Site ◽  
Water Dynamics ◽  
Small Scale ◽  
Strong Impact ◽  
Aquifer Recharge ◽  
Spatial Moments ◽  
Artificial Rainfall ◽  
Preferential Pathways

Preferential pathways allow rapid and non-uniform water movement in the subsurface due to strong heterogeneity of texture, composition, and hydraulic properties. Understanding the importance of preferential pathways is crucial, because they have strong impact on flow and transport hydrodynamics in the unsaturated zone. Particularly, improving knowledge of the water dynamics is essential for estimating travel time through soil to quantify hazards for groundwater, assess aquifer recharge rates, improve agricultural water management, and prevent surface stormflow and flooding hazards. Small scale field heterogeneities cannot be always captured by the limited number of point scale measurements collected. In order to overcome these limitations, noninvasive geophysical techniques have been widely used in the last decade to predict hydrodynamic processes, due to their capability to spatialize hydrogeophysical properties with high resolution. In the test site located in Bari, Southern Italy, the geophysical approach, based on electrical resistivity tomography (ERT) monitoring, has been implemented to detect preferential pathways triggered by an artificial rainfall event. ERT-derived soil moisture estimations were obtained in order to quantitatively predict the water storage (m3m−3), water velocity (ms−1), and spread (m2) through preferential pathways by using spatial moments analysis.

Vessel Wall Compliance and Transient Fluid Movement

1989 ◽  
pp. 203-217
Author(s):  
Perry L. Blackshear ◽  
Gertrude L. Blackshear ◽  
Paul F. Emerson
Keyword(s):  
Vessel Wall ◽  
Fluid Movement ◽  
Wall Compliance

Discrepancy between effects of cholera toxin on net fluid movement and cAMP levels in rat jejunum, ileum, and colon

1988 ◽  
Vol 33 (9) ◽  
pp. 1153-1158 ◽  
Author(s):  
Ulrich M. Farack ◽  
Rupert Gerzer ◽  
Therese M. Keravis ◽  
Klaus Loeschke
Keyword(s):  
Cholera Toxin ◽  
Rat Jejunum ◽  
Fluid Movement ◽  
Camp Levels

Improving Understanding of Peatland Hydrogeology Using Electrical Geophysics

2001 ◽  
Author(s):  
Lee D. Slater ◽  
Andrew Reeve ◽  
Danney Glaser
Keyword(s):  
Electrical Geophysics
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