Role of computer simulation in the application of knowledge to animal industries

1993 ◽  
Vol 44 (3) ◽  
pp. 541 ◽  
Author(s):  
JL Black ◽  
GT Davies ◽  
JF Fleming

The net financial return of an enterprise depends on the interaction among a great many factors. Some of these factors relate to the animal, some to its diet, some to its environment, some to the prevalence of disease and some to circumstances outside the production enterprise such as the premiums paid for products of different quality, the relative price structure of feeds and products, and the availability and cost of capital, labour, breeding stock and other resources. Although there has been a great deal of research into many of these factors, the complexity of the interactions between them makes it virtually impossible for the human mind to assess accurately the consequences of alternative management strategies on either the efficiency of production or the long-term profitability of a livestock enterprise. By transforming the concepts and knowledge into mathematical equations and integrating them in computer programs using simulation modelling techniques, this vast store of information can be applied directly to improving the management of commercial animal enterprises. Models are also valuable for defining research priorities. These simulation models should, as far as possible, be based on descriptions of the mechanisms perceived to determine animal function, not on empirical relationships of correlation and association. This need for mechanistic models has major implications for the direction and nature of future research into animal function. Mechanistic models of animal performance alone are unlikely to result in the widespread application of knowledge to the animal industries. Models must be integrated with other modules that cover the major areas of an enterprise determining its profitability, as well as with programming features that make the whole Decision Support Software System easy to use and interpret by industry personnel. The animal model is likely to represent less than 20% of a commercially useful package. A major factor limiting the application of animal growth models is lack of an adequate description of the conditions within commercial enterprises. Collection of such data is difficult and frequently regarded as unattractive by scientists and funding organisations, but it is essential for effective application of existing knowledge through simulation models. Furthermore, industry must make frequent measurements of factors determining animal performance and enterprise profitability if the significance of predictions from animal models is to be evaluated fully. An example is presented illustrating how simulation models can improve the biological efficiency and profitability of a commercial animal enterprise when this information is available.

2005 ◽  
Vol 56 (4) ◽  
pp. 317 ◽  
Author(s):  
S. Pande ◽  
K. H. M. Siddique ◽  
G. K. Kishore ◽  
B. Bayaa ◽  
P. M. Gaur ◽  
...  

Ascochyta blight (AB), caused by Ascochyta rabiei is a major disease of chickpea (Cicer arietinum L.), especially in areas where cool, cloudy, and humid weather persists during the crop season. Several epidemics of AB causing complete yield loss have been reported. The fungus mainly survives between seasons through infected seed and in infected crop debris. Despite extensive pathological and molecular studies, the nature and extent of pathogenic variability in A. rabiei have not been clearly established. Accumulation of phenols, phytoalexins (medicarpin and maackiain), and hydrolytic enzymes has been associated with host-plant resistance (HPR). Seed treatment and foliar application of fungicides are commonly recommended for AB management, but further information on biology and survival of A. rabiei is needed to devise more effective management strategies. Recent studies on inheritance of AB resistance indicate that several quantitative trait loci (QTLs) control resistance. In this paper we review the biology of A. rabiei, HPR, and management options, with an emphasis on future research priorities.


2021 ◽  
pp. jrheum.201330
Author(s):  
Zachary S. Wallace ◽  
Huifeng Yun ◽  
Jeffrey R. Curtis ◽  
Lang Chen ◽  
John H. Stone ◽  
...  

Objective ANCA-associated vasculitis (AAV) management has evolved substantially over the last two decades. We sought to characterize AAV treatment patterns in the United States. Methods We identified AAV patients in the Rheumatology Informatics System for Effectiveness (RISE) registry who had at least two rheumatology clinician visits between January 1st, 2015 and December 31st, 2017. Demographics, medications, laboratory test results, and billing codes were extracted from the medical record. Demographic and prescription trends were assessed overall and across US regions. Results We identified 1,462 AAV patients, 259 (18%) with new or relapsing AAV. The majority were classified as having granulomatosis with polyangiitis (GPA, 75%). The mean age was 59.8 years and 59% were female. The majority of patients were in the South (45%) followed by the Mid-West (32%), West (12%), and Northeast (8%). Patients had a median of 3 visits and follow-up of 579 days. The most commonly prescribed medications during the study period were glucocorticoids (86%) followed by rituximab (45%), methotrexate (33%), azathioprine (32%) and mycophenolate mofetil (18%); cyclophosphamide was rarely used (97, 7%). At the most recent visits in RISE, 47% of patients were on glucocorticoids. Prescription trends were similar across regions. Conclusion This is the first study to evaluate the demographics and management of AAV by rheumatologists outside of major referral centers. Management strategies vary widely but cyclophosphamide is rarely used. These observations can be used to inform future research priorities. Additional studies are needed to characterize AAV severity in RISE and patient and provider treatment preferences.


2017 ◽  
Vol 74 (6) ◽  
pp. 894-906 ◽  
Author(s):  
Abbey E. Camaclang ◽  
Janelle M.R. Curtis ◽  
Ilona Naujokaitis-Lewis ◽  
Mark S. Poesch ◽  
Marten A. Koops

We developed a spatially explicit simulation model of poaching behaviour to quantify the relative influence of the intensity, frequency, and spatial distribution of poaching on metapopulation viability. We integrated our model of poaching with a stochastic, habitat-based, spatially explicit population model, applied it to examine the impact of poaching on northern abalone (Haliotis kamtschatkana) metapopulation dynamics in Barkley Sound, British Columbia, Canada, and quantified model sensitivity to input parameters. While demographic parameters remained important in predicting extinction probabilities for northern abalone, our simulations indicate that the odds of extinction are twice as high when populations are subjected to poaching. Viability was influenced by poaching variables that affect the total number of individuals removed. Of these, poaching mortality was the most influential in predicting metapopulation viability, with each 0.1 increase in mortality rate resulting in 22.6% increase in the odds of extinction. By contrast, the location and spatial correlation of events were less important predictors of viability. When data are limited, simulation models of poaching combined with sensitivity analyses can be useful in informing management strategies and future research directions.


Author(s):  
Edwina A. Brown ◽  
Osasuyi Iyasere

The demographics of the renal population have evolved, such that the elderly are the fastest growing group. Consequently, the multidisciplinary renal team often encounters clinical issues associated with advancing age. In this chapter, frailty, falls, and cognitive impairment are discussed as underrecognized geriatric syndromes in patients with chronic kidney disease. A case history illustrates how these syndromes tend to co-exist and affect quality of life and survival. The risk factors, management strategies, and future research priorities are discussed, recognizing the importance of a multidisciplinary approach to the management of elderly patients with kidney disease.


2015 ◽  
Vol 25 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Ryan W. McCreery ◽  
Elizabeth A. Walker ◽  
Meredith Spratford

The effectiveness of amplification for infants and children can be mediated by how much the child uses the device. Existing research suggests that establishing hearing aid use can be challenging. A wide range of factors can influence hearing aid use in children, including the child's age, degree of hearing loss, and socioeconomic status. Audiological interventions, including using validated prescriptive approaches and verification, performing on-going training and orientation, and communicating with caregivers about hearing aid use can also increase hearing aid use by infants and children. Case examples are used to highlight the factors that influence hearing aid use. Potential management strategies and future research needs are also discussed.


Crisis ◽  
2017 ◽  
Vol 38 (3) ◽  
pp. 202-206 ◽  
Author(s):  
Karl Andriessen ◽  
Dolores Angela Castelli Dransart ◽  
Julie Cerel ◽  
Myfanwy Maple

Abstract. Background: Suicide can have a lasting impact on the social life as well as the physical and mental health of the bereaved. Targeted research is needed to better understand the nature of suicide bereavement and the effectiveness of support. Aims: To take stock of ongoing studies, and to inquire about future research priorities regarding suicide bereavement and postvention. Method: In March 2015, an online survey was widely disseminated in the suicidology community. Results: The questionnaire was accessed 77 times, and 22 records were included in the analysis. The respondents provided valuable information regarding current research projects and recommendations for the future. Limitations: Bearing in mind the modest number of replies, all from respondents in Westernized countries, it is not known how representative the findings are. Conclusion: The survey generated three strategies for future postvention research: increase intercultural collaboration, increase theory-driven research, and build bonds between research and practice. Future surveys should include experiences with obtaining research grants and ethical approval for postvention studies.


Author(s):  
Lydia Powell

While it is not surprising that political factors shape the Indian energy landscape, few systematic attempts have been made to address exactly what interests most heavily influence energy choices and the precise nature of their impacts. Available research suggests that scholars need to move beyond simplistic explanations, such as lack of political will or capacity constraints, and recognize a broader set of interacting social, structural, institutional, and political agency variables. The technocratic analyses and projections based on simulation models that dominate the academic literature neglect political and social perspectives as unscientific, esoteric, or theoretical. Thus this chapter argues that future research should focus on political and economic power relations at the national, regional, and domestic levels when tracking poor outcomes of energy choices and policies. In the future, an emphasis on theoretically informed analysis will deepen understanding of hard choices related to the equitable distribution of energy in India and also facilitate implementation of more progressive energy policies.


2021 ◽  
Vol 7 (3) ◽  
pp. e001108
Author(s):  
Omar Heyward ◽  
Stacey Emmonds ◽  
Gregory Roe ◽  
Sean Scantlebury ◽  
Keith Stokes ◽  
...  

Women’s rugby (rugby league, rugby union and rugby sevens) has recently grown in participation and professionalisation. There is under-representation of women-only cohorts within applied sport science and medicine research and within the women’s rugby evidence base. The aims of this article are: Part 1: to undertake a systematic-scoping review of the applied sport science and medicine of women’s rugby, and Part 2: to develop a consensus statement on future research priorities. This article will be designed in two parts: Part 1: a systematic-scoping review, and Part 2: a three-round Delphi consensus method. For Part 1, systematic searches of three electronic databases (PubMed (MEDLINE), Scopus, SPORTDiscus (EBSCOhost)) will be performed from the earliest record. These databases will be searched to identify any sport science and medicine themed studies within women’s rugby. The Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews will be adhered to. Part 2 involves a three-round Delphi consensus method to identify future research priorities. Identified experts in women’s rugby will be provided with overall findings from Part 1 to inform decision-making. Participants will then be asked to provide a list of research priority areas. Over the three rounds, priority areas achieving consensus (≥70% agreement) will be identified. This study has received institutional ethical approval. When complete, the manuscript will be submitted for publication in a peer-reviewed journal. The findings of this article will have relevance for a wide range of stakeholders in women’s rugby, including policymakers and governing bodies.


Author(s):  
Rosa Town ◽  
Daniel Hayes ◽  
Peter Fonagy ◽  
Emily Stapley

AbstractThere is evidence that young people generally self-manage their mental health using self-care strategies, coping methods and other self-management techniques, which may better meet their needs or be preferable to attending specialist mental health services. LGBTQ+ young people are more likely than their peers to experience a mental health difficulty and may be less likely to draw on specialist support due to fears of discrimination. However, little is known about LGBTQ+ young people’s experiences and perceptions of self-managing their mental health. Using a multimodal qualitative design, 20 LGBTQ+ young people participated in a telephone interview or an online focus group. A semi-structured schedule was employed to address the research questions, which focussed on LGBTQ+ young people’s experiences and perceptions of self-managing their mental health, what they perceived to stop or help them to self-manage and any perceived challenges to self-management specifically relating to being LGBTQ+ . Reflexive thematic analysis yielded three key themes: (1) self-management strategies and process, (2) barriers to self-management and (3) facilitators to self-management. Participants’ most frequently mentioned self-management strategy was ‘speaking to or meeting up with friends or a partner’. Both barriers and facilitators to self-management were identified which participants perceived to relate to LGBTQ+ identity. Social support, LGBTQ+ youth groups and community support were identified as key facilitators to participants’ self-management of their mental health, which merits further investigation in future research. These findings also have important implications for policy and intervention development concerning LGBTQ+ young people’s mental health.


2021 ◽  
pp. 135245852199997
Author(s):  
Kathleen M Zackowski ◽  
Jennifer Freeman ◽  
Giampaolo Brichetto ◽  
Diego Centonze ◽  
Ulrik Dalgas ◽  
...  

Background: People with multiple sclerosis (MS) experience myriad symptoms that negatively affect their quality of life. Despite significant progress in rehabilitation strategies for people living with relapsing-remitting MS (RRMS), the development of similar strategies for people with progressive MS has received little attention. Objective: To highlight key symptoms of importance to people with progressive MS and stimulate the design and implementation of high-quality studies focused on symptom management and rehabilitation. Methods: A group of international research experts, representatives from industry, and people affected by progressive MS was convened by the International Progressive MS Alliance to devise research priorities for addressing symptoms in progressive MS. Results: Based on information from the MS community, we outline a rationale for highlighting four symptoms of particular interest: fatigue, mobility and upper extremity impairment, pain, and cognitive impairment. Factors such as depression, resilience, comorbidities, and psychosocial support are described, as they affect treatment efficacy. Conclusions: This coordinated call to action—to the research community to prioritize investigation of effective symptom management strategies, and to funders to support them—is an important step in addressing gaps in rehabilitation research for people affected by progressive MS.


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