Phosphorus turnover in sheep

1967 ◽  
Vol 18 (4) ◽  
pp. 635 ◽  
Author(s):  
FM Tomas ◽  
RJ Moir ◽  
M Somers
Keyword(s):  
Rumen Fluid ◽  
Inorganic Phosphorus ◽  
Dietary Phosphorus ◽  
The Mean ◽  
Four Levels ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Turnover ◽  
Very High ◽  
Phosphorus Intake ◽  
Phosphorus Levels

Rumen fluid, serum, and parotid salivary inorganic phosphorus concentrations in sheep given four levels of dietary phosphorus (0.42–4.02 g/day) were directly related to phosphorus intake. There was a very high correlation (r = +0.91; P < 0.001) between inorganic phosphorus concentrations in centrifuged rumen fluid and in parotid saliva. Serum inorganic phosphorus concentrations were positively correlated with those of saliva (r = +0.64; P< 0.05) and also with those in centrifuged rumen fluid (r = +0.75; P<0.01). The range in the mean daily saliva volumes collected from one parotid gland in each sheep was 3.2 to 4.2 l/day. The calculated minimum total salivary phosphorus secretion ranged from 3.0 g/day on the lowest dietary phosphorus intake to 5.3 g/day on the highest, the corresponding ratios of salivary to dietary phosphorus being from 7.24 to 1 .32 g/g. It appeared that salivary phosphorus was the major source of phosphorus to the rumen, and was also the principal determinant of rumen fluid inorganic phosphorus levels.

scholarly journals Trends in Total, Added, and Natural Phosphorus Intake in Adult Americans, NHANES 1988–1994 to NHANES 2015–2016

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2249
Author(s):  
Kristin Fulgoni ◽  
Victor Fulgoni
Keyword(s):  
Phosphorus Content ◽  
Health And Nutrition ◽  
Dietary Phosphorus ◽  
Naturally Occurring ◽  
Novel Approach ◽  
The Usa ◽  
Daily Allowance ◽  
The Mean ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake

Dietary phosphorus intake in the USA has been consistently greater than the Recommended Daily Allowance (RDA) with several studies reporting associations between intake and health risks as well as all-cause mortality within healthy subjects and patients with chronic kidney disease (CKD). The current study utilized a novel approach to calculate added phosphorus content in foods to determine sources (National Health and Nutrition Examination Survey, NHANES 2001–2016, n = 39,796) and trends in consumption (NHANES 1988–1994, 2001–2016, n = 55,744) of total, naturally occurring, and added phosphorus. Among adults (19+ years), the mean intake of total and natural phosphorus (mg/day) in 1988–1994 as compared with 2015–2016 increased (total: 1292 ± SE 11 vs. 1398 ± SE 17; natural: 1113 ± SE 10 vs. 1243 ± SE 16 mg/day); in contrast, added phosphorus intake decreased during this time (178 ± SE 2.9 vs. 155 ± SE 4.1 mg/day). Added phosphorus as a percent of total ranged from about 14.6% in 1988–1994 to about 11.6% in 2015–2016. The top five sources of total and naturally occurring phosphorus, representing approximately 20% of intake, were cheese, pizza, chicken (whole pieces), reduced-fat milk, and eggs/omelets. The top five sources of added phosphorus were cheese, soft drinks, cakes/pies, rolls/buns, and cookies/brownies, representing 45% of added phosphorus in the diet. Consumption of added phosphorus has decreased over the past few decades, possibly due to increased demand for foods with less additives/ingredients but may also be due to inaccurate phosphorus values in nutrition databases. Further studies are needed to validate the added phosphorus calculations utilized in this study and nutrition databases should consider providing added phosphorus content.

scholarly journals The Percentage of Dietary Phosphorus Excreted in the Urine Varies by Dietary Pattern in a Randomized Feeding Study in Adults

2019 ◽  
Vol 149 (5) ◽  
pp. 816-823 ◽  
Author(s):  
Scott T McClure ◽  
Casey M Rebholz ◽  
Katherine M Phillips ◽  
Catherine M Champagne ◽  
Elizabeth Selvin ◽  
...  
Keyword(s):  
Control Diet ◽  
Dash Diet ◽  
Phosphorus Excretion ◽  
Feeding Study ◽  
Dietary Phosphorus ◽  
The Mean ◽  
Dietary Phosphorus Intake ◽  
Urinary Phosphorus Excretion ◽  
Stage 1 ◽  
Phosphorus Intake

ABSTRACTBackgroundUrinary phosphorus excretion has been proposed as a recovery biomarker of dietary phosphorus intake. However, it is unclear whether phosphorus excretion is constant across a range of dietary and nondietary factors.ObjectiveWe assessed whether percentage urinary phosphorus excretion is constant across 3 dietary patterns in the Dietary Approaches to Stop Hypertension (DASH) trial.MethodsDASH is a completed feeding study of 459 prehypertensive and stage 1 hypertensive adults (52% male, 56% black). After a 3-wk run-in on a typical American (control) diet, participants were randomly assigned to the control diet, a diet rich in fruits and vegetables (FV diet), or a diet rich in fruits, vegetables, and low-fat dairy with reduced saturated fat and cholesterol (DASH diet) for 8 wk. We estimated the percentage phosphorus excretion as urinary phosphorus excretion (from 24 h urine) divided by phosphorus intake (from analyzed food composites). Differences between group means for all 3 diets were compared by ANOVA followed by pairwise comparisons with Tukey's honest significant difference test.ResultsAt the end of the intervention, the mean phosphorus intake was 1176 mg/d (95% CI: 1119, 1233 mg/d), 1408 mg/d (1352, 1464 mg/d), and 2051 mg/d (1994, 2107 mg/d) in the control, FV, and DASH diet, respectively (P < 0.001, all comparisons). The mean phosphorus excretion was 734 mg/d (682, 787 mg/d), 705 mg/d (654, 756 mg/d), and 872 mg/d (820, 923 mg/d) in the control, FV, and DASH diet, respectively (P = 0.74 control vs. FV, P < 0.001 all other comparisons). The mean percentage phosphorus excretion was 63% (60%, 67%), 51% (48%, 54%), and 43% (39%, 46%) in the control, FV, and DASH diet, respectively (P < 0.001, all comparisons).ConclusionsThese findings in prehypertensive and stage 1 hypertensive adults strongly suggest that urinary phosphorus excretion should not be used as a recovery biomarker for dietary phosphorus intake, given the wide range of urinary phosphorus excretion across dietary patterns. This trial is registered at clinicaltrials.gov as NCT0000054.

Circulating phosphorus level and risk of prostate cancer: a Mendelian randomization study

2021 ◽  
Author(s):  
Linshuoshuo Lv ◽  
Ding Ye ◽  
Jie Chen ◽  
Yu Qian ◽  
Alan Nuo Fu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Observational Studies ◽  
Mendelian Randomization ◽  
Meta Analysis ◽  
Serum Phosphorus ◽  
Phosphorus Level ◽  
Dietary Phosphorus ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake ◽  
Phosphorus Levels

Abstract Background Recent observational studies have suggested that circulating phosphorus levels are positively associated with risk of prostate cancer. However, little is known about the causal direction of the association. Objective To explore the potential causal relationship between circulating phosphorus and risk of prostate cancer, we conducted a Mendelian randomization (MR) study. Design Summary statistics of prostate cancer were obtained from a meta-analysis of genome-wide association studies (GWAS) consisting of 79,148 cases and 61,106 controls. Single nucleotide polymorphisms (SNP) associated with serum phosphorus level were selected from a GWAS of 291,408 individuals from the UK Biobank. MR analysis was performed using the inverse-variance weighted (IVW) method, supplemented with simple-median, weighted-median, maximum likelihood-based, MR-Egger regression and MR-PRESSO test. We also performed a meta-analysis of observational studies to assess the associations of dietary phosphorus intake and serum phosphorus level with risk of prostate cancer. Results In the MR analysis, a total of 125 independent SNPs associated with serum phosphorus levels were used as instrumental variables. Genetically predicted serum phosphorus levels were associated with a 19% increased risk of prostate cancer (95% confidence interval (CI): 9%, 31%) per one SD increment of serum phosphorus by IVW (P = 1.82 × 10–4). Sensitivity analyses using alternative MR methods produced similar positive associations, and no evidence of pleiotropy was detected by MR-Egger regression (P = 0.422). For meta-analysis, eight studies for dietary phosphorus intake and four for serum phosphorus levels were included involving a total of 669,080 participants. Consistently, high dietary phosphorus intake and serum phosphorus levels were associated with an 8% (95% CI: 4%, 12%) and 7% (95% CI: 1%, 14%) increase in prostate cancer risk, respectively. Conclusions Our study suggested a potential causal relationship between circulating phosphorus and risk of prostate cancer. Further studies are warranted to elucidate the underlying mechanism of phosphorus in the development of prostate cancer.

scholarly journals High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III

2013 ◽  
Vol 99 (2) ◽  
pp. 320-327 ◽  
Author(s):  
Alex R Chang ◽  
Mariana Lazo ◽  
Lawrence J Appel ◽  
Orlando M Gutiérrez ◽  
Morgan E Grams
Keyword(s):  
Nhanes Iii ◽  
Dietary Phosphorus ◽  
All Cause Mortality ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake

High dietary phosphorus intake is associated with an increased risk of type 2 diabetes in the large prospective E3N cohort study

2018 ◽  
Vol 37 (5) ◽  
pp. 1625-1630 ◽  
Author(s):  
Francesca Romana Mancini ◽  
Aurélie Affret ◽  
Courtney Dow ◽  
Beverley Balkau ◽  
Françoise Clavel-Chapelon ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Dietary Phosphorus ◽  
Increased Risk ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake

scholarly journals Effect of dietary phosphorus intake and age on intestinal phosphorus absorption efficiency and phosphorus balance in male rats

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207601 ◽  
Author(s):  
Colby J. Vorland ◽  
Pamela J. Lachcik ◽  
Loretta O. Aromeh ◽  
Sharon M. Moe ◽  
Neal X. Chen ◽  
...  
Keyword(s):  
Absorption Efficiency ◽  
Male Rats ◽  
Phosphorus Balance ◽  
Phosphorus Absorption ◽  
Dietary Phosphorus ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake

scholarly journals The influence of dietary phosphorus intake on the rate of bone metabolism in sheep

1966 ◽  
Vol 20 (4) ◽  
pp. 727-732 ◽  
Author(s):  
V. R. Young ◽  
J. R. Luick ◽  
G. P. Lofgreen
Keyword(s):  
Bone Metabolism ◽  
Turnover Rates ◽  
Isotope Techniques ◽  
Dietary Phosphorus ◽  
Exchangeable Ca ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Depletion ◽  
Phosphorus Intake ◽  
P Depletion ◽  
Calcium Pool

1. A combination of balance and isotope techniques was used to determine the influence of phosphorus depletion on the size of the exchangeable calcium pool and on the rates of Ca deposition in and removal from the whole skeleton of sheep. 2. The exchangeable Ca pool was reduced in size in the depleted sheep to approximately 50% of that in the controls. 3. The rates of Ca deposition in and removal from bone were reduced by P depletion and the rate of Ca transfer from the pool was reduced slightly. 4. The turnover rates of the exchangeable Ca pool and bone Ca in sheep appear to be similar to values published for man.

scholarly journals Twenty-Four-Hour Urine Phosphorus as a Biomarker of Dietary Phosphorus Intake and Absorption in CKD

2018 ◽  
Vol 13 (7) ◽  
pp. 1002-1012 ◽  
Author(s):  
Elizabeth R. Stremke ◽  
Linda D. McCabe ◽  
George P. McCabe ◽  
Berdine R. Martin ◽  
Sharon M. Moe ◽  
...  
Keyword(s):  
Dietary Phosphorus ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake

scholarly journals Estimate of dietary phosphorus intake using 24-h urine collection

2014 ◽  
Vol 55 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Yuuka Morimoto ◽  
Masae Sakuma ◽  
Hiroyuki Ohta ◽  
Akitsu Suzuki ◽  
Asami Matsushita ◽  
...  
Keyword(s):  
Urine Collection ◽  
Dietary Phosphorus ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake
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