Optical coherence tomograph for non-invasive examination of the human middle ear

2021 ◽  
Vol 51 (1) ◽  
pp. 38-42
Author(s):  
P A Shilyagin ◽  
A A Novozhilov ◽  
T E Abubakirov ◽  
A L Dilenyan ◽  
A V Shakhov ◽  
...  
Keyword(s):  
Middle Ear ◽  
Optical Coherence ◽  
Non Invasive ◽  
Human Middle Ear ◽  
Optical Coherence Tomograph

scholarly journals Investigation of bacterial biofilm in the human middle ear using optical coherence tomography and acoustic measurements

2013 ◽  
Vol 301 ◽  
pp. 193-200 ◽  
Author(s):  
Cac T. Nguyen ◽  
Sarah R. Robinson ◽  
Woonggyu Jung ◽  
Michael A. Novak ◽  
Stephen A. Boppart ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Middle Ear ◽  
Bacterial Biofilm ◽  
Optical Coherence ◽  
Acoustic Measurements ◽  
Human Middle Ear

Optical coherence tomography in otolaryngology

2011 ◽  
Vol 152 (28) ◽  
pp. 1125-1132
Author(s):  
Attila Óvári ◽  
Hans-Wilhelm Pau ◽  
Tino Just
Keyword(s):  
Optical Coherence Tomography ◽  
Middle Ear ◽  
Reliable Method ◽  
Imaging Technique ◽  
Cancer Tissue ◽  
Optical Coherence ◽  
Targeted Biopsy ◽  
Ear Diseases ◽  
Pharyngeal Mucosa ◽  
Non Invasive

Optical coherence tomography is an imaging technique based on coherence interferometry. It is used in many medical fields due to its non-invasive imaging capabilities with micrometer resolution. The aim of the authors was to review the applicability of the optical coherence tomography in otolaryngology. Literature data and their own studies show that optical coherence tomography is a reliable method for identifying and targeted biopsy of inflammated, pre-malignant or cancer tissue in human laryngeal and pharyngeal mucosa. Another emerging field for optical coherence tomography is diagnosis of middle ear diseases, especially stapes ankylosis and cholesteatoma. Orv. Hetil., 2011, 152, 1125–1132.[Formula: see text]

scholarly journals In Vivo Functional Imaging of the Human Middle Ear with a Hand-Held Optical Coherence Tomography Device

2021 ◽  
Author(s):  
Christopher Lui ◽  
Wihan Kim ◽  
James Dewey ◽  
Frank MACÍAS-ESCRIVÁ ◽  
Kumara RATNAYAKE ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Functional Imaging ◽  
Middle Ear ◽  
Optical Coherence ◽  
Human Middle Ear ◽  
In Vivo Functional Imaging

Are mucin genes yet to be cloned expressed by human middle ear mucosa?

1998 ◽  
Vol 23 (3) ◽  
pp. 265-265 ◽  
Author(s):  
Hutton ◽  
Birchall ◽  
French ◽  
Kubba ◽  
Severn ◽  
...  
Keyword(s):  
Middle Ear ◽  
Middle Ear Mucosa ◽  
Mucin Genes ◽  
Human Middle Ear

scholarly journals Non-invasive three-dimensional thickness analysis of oral epithelium based on optical coherence tomography—development and diagnostic performance

Heliyon ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. e06645
Author(s):  
Charlotte Theresa Trebing ◽  
Sinan Sen ◽  
Stefan Rues ◽  
Christopher Herpel ◽  
Maria Schöllhorn ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diagnostic Performance ◽  
Three Dimensional ◽  
Oral Epithelium ◽  
Optical Coherence ◽  
Non Invasive

scholarly journals Immunohistochemical and qPCR Detection of SARS-CoV-2 in the Human Middle Ear Versus the Nasal Cavity: Case Series

2021 ◽  
Author(s):  
Arwa Kurabi ◽  
Kwang Pak ◽  
Adam S. DeConde ◽  
Allen F. Ryan ◽  
Carol H. Yan
Keyword(s):  
Nasal Cavity ◽  
Middle Ear ◽  
Viral Infections ◽  
Case Series ◽  
Middle Ear Mucosa ◽  
Viral Receptor ◽  
Tissue Samples ◽  
Angiotensin Converting Enzyme 2 ◽  
Nasal Tissue ◽  
Human Middle Ear

AbstractViral infections have already been implicated with otitis media and sudden sensorineural hearing loss. However, the pathophysiology of COVID-19 as it relates to otologic disorders is not well-defined. With the spread of SARS-CoV-2, it is important to evaluate its colonization of middle ear mucosa. Middle ear and nasal tissue samples for quantitative RT-PCR and histologic evaluations were obtained from post-mortem COVID-19 patients and non-diseased control patients. Here we present evidence that SARS-CoV-2 colonizes the middle ear epithelium and co-localizes with the primary viral receptor, angiotensin-converting enzyme 2 (ACE2). Both middle ear and nasal epithelial cells show relatively high expression of ACE2, required for SARS-CoV-2 entry. The epithelial cell adhesion molecule (EpCAM) was use as a biomarker of epithelia. Furthermore, we found that the viral load in the middle ear is lower than that present in the nasal cavity.

Label-free non-invasive classification of rice seeds using optical coherence tomography assisted with deep neural network

2021 ◽  
Vol 137 ◽  
pp. 106861
Author(s):  
Deepa Joshi ◽  
Ankit Butola ◽  
Sheetal Raosaheb Kanade ◽  
Dilip K. Prasad ◽  
S.V. Amitha Mithra ◽  
...  
Keyword(s):  
Neural Network ◽  
Optical Coherence Tomography ◽  
Deep Neural Network ◽  
Optical Coherence ◽  
Label Free ◽  
Non Invasive ◽  
Rice Seeds

scholarly journals Monitoring New Long-Lasting Intravitreal Formulation for Glaucoma with Vitreous Images Using Optical Coherence Tomography

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 217
Author(s):  
Maria Jesus Rodrigo ◽  
Amaya Pérez del Palomar ◽  
Alberto Montolío ◽  
Silvia Mendez-Martinez ◽  
Manuel Subias ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Relative Intensity ◽  
Therapeutic Option ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Aggregate Size ◽  
Daily Practice ◽  
Optical Coherence ◽  
Non Invasive ◽  
Invasive Method

Intravitreal injection is the gold standard therapeutic option for posterior segment pathologies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropathies in daily practice, nor is there a non-invasive method to monitor drug levels in the vitreous. Here we show that a glaucoma treatment combining a hypotensive and neuroprotective intravitreal formulation (IF) of brimonidine–Laponite (BRI/LAP) can be monitored non-invasively using vitreoretinal interface imaging captured with optical coherence tomography (OCT) over 24 weeks of follow-up. Qualitative and quantitative characterisation was achieved by analysing the changes in vitreous (VIT) signal intensity, expressed as a ratio of retinal pigment epithelium (RPE) intensity. Vitreous hyperreflective aggregates mixed in the vitreous and tended to settle on the retinal surface. Relative intensity and aggregate size progressively decreased over 24 weeks in treated rat eyes as the BRI/LAP IF degraded. VIT/RPE relative intensity and total aggregate area correlated with brimonidine levels measured in the eye. The OCT-derived VIT/RPE relative intensity may be a useful and objective marker for non-invasive monitoring of BRI/LAP IF.

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