Radon and Lung Cancer in Cornwall and Devon

1993 ◽  
Vol 25 (9) ◽  
pp. 1361-1366 ◽  
Author(s):  
R M Haynes
Keyword(s):  
Lung Cancer ◽  
Cancer Mortality ◽  
Indoor Radon ◽  
Lung Cancer Mortality ◽  
Radiological Protection ◽  
Preventive Action ◽  
Cross Sectional ◽  
Radon Measurements ◽  
The Relationship ◽  
Current Advice

The relationship between average indoor levels of radon and lung cancer mortality in the counties of Cornwall and Devon, England, are investigated. The associations of population density, social-class distribution, and regional smoking prevalence with lung cancer mortality in the local-authority districts of England and Wales were estimated by regression analysis. Low rates of lung cancer in Cornwall and Devon were predicted from the relationship. The differences between observed and predicted mortality in Cornwall and Devon districts were compared with average indoor levels of radon, which varied considerably between districts. Residual variations in lung cancer mortality were not significantly correlated with average indoor radon measurements. The current advice of the National Radiological Protection Board to government is to concentrate radon measurements, remedial action, and preventive action principally on Cornwall and Devon, but cross-sectional geographical data do not support the hypothesis that raised levels of radon indoors in southwest England have an important effect on lung cancer mortality.

scholarly journals Long-Term Exposure to Air Pollutants and Cancer Mortality: A Meta-Analysis of Cohort Studies

2018 ◽  
Vol 15 (11) ◽  
pp. 2608 ◽  
Author(s):  
Hong-Bae Kim ◽  
Jae-Yong Shim ◽  
Byoungjin Park ◽  
Yong-Jae Lee
Keyword(s):  
Lung Cancer ◽  
Cohort Studies ◽  
Cancer Mortality ◽  
Air Pollutants ◽  
Meta Analysis ◽  
Final Analysis ◽  
Lung Cancer Mortality ◽  
Pm 2.5 ◽  
The Relationship

The aim of this study was to examine the relationship between main air pollutants and all cancer mortality by performing a meta-analysis. We searched PubMed, EMBASE (a biomedical and pharmacological bibliographic database of published literature produced by Elsevier), and the reference lists of other reviews until April 2018. A random-effects model was employed to analyze the meta-estimates of each pollutant. A total of 30 cohort studies were included in the final analysis. Overall risk estimates of cancer mortality for 10 µg/m3 per increase of particulate matter (PM)2.5, PM10, and NO2 were 1.17 (95% confidence interval (CI): 1.11–1.24), 1.09 (95% CI: 1.04–1.14), and 1.06 (95% CI: 1.02–1.10), respectively. With respect to the type of cancer, significant hazardous influences of PM2.5 were noticed for lung cancer mortality and non-lung cancer mortality including liver cancer, colorectal cancer, bladder cancer, and kidney cancer, respectively, while PM10 had harmful effects on mortality from lung cancer, pancreas cancer, and larynx cancer. Our meta-analysis of cohort studies indicates that exposure to the main air pollutants is associated with increased mortality from all cancers.

scholarly journals Full Analysis of Lung Cancer Mortality/Radon Relationship with Simple Nonlinear Concepts

Dose-Response ◽  
2021 ◽  
Vol 19 (1) ◽  
pp. 155932582096099
Author(s):  
Ralph W. Lai
Keyword(s):  
Lung Cancer ◽  
Cancer Mortality ◽  
Indoor Radon ◽  
Lung Cancer Mortality ◽  
Coefficient Of Determination ◽  
Rate Versus ◽  
The Usa ◽  
Full Analysis ◽  
Nonlinear Change ◽  
Log Linear

We analyze the relationship between the lung cancer mortality and the indoor radon intensity from the viewpoint of nonlinear mathematics. We conclude that their relationship is governed by the proportionality law where the cumulative lung cancer mortality Y is negatively proportional to the cumulative radon intensity X; or specifically, the nonlinear change of nonlinear face value (qYu – qY) is negatively proportional to the nonlinear change of nonlinear face value (X – Xb). The author obtained a set of data from late Professor Cohen on the lung-cancer mortality rate versus indoor radon level collected from 1,597 counties and territory of the USA. We initially presented the data as various primitive elementary graphs; then extended them to the primary graphs, leading graphs, and the proportionality graphs. The article emphasizes the building of a straight-line proportionality relationship for the dose-response data in a log-linear and/or log-log graphs. It demonstrates a straightforward methodology for solving the key upper asymptotes (Yu) for the proportionality equation using the Microsoft Excel via determining the “coefficient of determination”. (Note: q = log, Yu = upper asymptote of Y, Xb = bottom asymptote of X)

Relationship between glucosamine use and the risk of lung cancer: data from a nationwide prospective cohort study

2021 ◽  
pp. 2101399
Author(s):  
Guowei Li ◽  
Xuhui Zhang ◽  
Yingxin Liu ◽  
Junguo Zhang ◽  
Likang Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Family History ◽  
Prospective Cohort Study ◽  
Cancer Mortality ◽  
Prospective Cohort ◽  
Lung Cancer Mortality ◽  
Hazard Ratio ◽  
The Relationship

BackgroundResearch on glucosamine shows anti-inflammatory and anti-cancer benefits with a minimal adverse effects. We aimed to explore the relationship between use of glucosamine and risk of lung cancer and lung cancer mortality based on data from the large-scale nationwide prospective UK Biobank cohort study.MethodsParticipants were enrolled between the year 2006 and 2010 and followed up to 2020. Cox proportion hazards model were used to assess the relationship between glucosamine use and risk of lung cancer and lung cancer mortality. Subgroup analyses and sensitivity analyses were performed to explore the potential effect modifications and the robustness of main findings.ResultsA total of 439,393 participants (mean age: 56 years; 53% females) with a mean follow-up of 11 years were included for analyses. There were 82,603 (18.80%) participants reporting regular use of glucosamine at baseline. During follow-up, there were 1,971 (0.45%) lung cancer events documented. Glucosamine use was significantly associated with a decreased risk of lung cancer (hazard ratio=0.84, 95% CI: 0.75–0.92, p<0.001) and lung cancer mortality (hazard ratio=0.88, 95% CI: 0.81–0.96, p=0.002) in fully-adjusted models. A stronger association between glucosamine use and decreased lung cancer risk was observed in participants with a family history of lung cancer when compared to those without a family history.ConclusionRegular use of glucosamine was significantly related with decreased risk of lung cancer and lung cancer mortality, based on data from this nationwide prospective cohort study.

scholarly journals Relationships among Indoor Radon, Earthquake Magnitude Data and Lung Cancer Risks in a Residential Building of an Apulian Town (Southern Italy)

Atmosphere ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1342
Author(s):  
Luigi Vimercati ◽  
Domenica Cavone ◽  
Maria Celeste Delfino ◽  
Luigi De Maria ◽  
Antonio Caputi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Indoor Radon ◽  
Residential Building ◽  
Earthquake Magnitude ◽  
Reference Level ◽  
Data Sets ◽  
Prevention Measures ◽  
Radon Measurements ◽  
The Relationship ◽  
Radon Concentrations

(1) Background: The association of radon-222 with lung cancer is well studied. The aim of the study was to validate a model of indoor radon measurements, to apply radon software to estimate lung cancer cases that are attributable to radon and to study the relationship between radon and earthquakes. (2) Methods: Different data detectors were used to obtain radon measurements in different places. Continuous data collection and predictions of indoor radon concentrations were carried out. Software was used to assess radon-attributable lung cancer cases, and data related to earthquake magnitudes were downloaded from Italian Vulcanology Institute. (3) Results: As expected, the highest radon concentrations were observed on the ground floor (232 ± 232 Bq/m3), with higher values measured during winter than in other seasons. The comparison of the detectors showed the overlapping of the two detectors-measured data sets. The cases of lung cancer that were attributable to radon in Locorotondo were studied (3.66/10,000). From the multivariate analysis of the relationship between high radon concentrations and high earthquake magnitude values, they show statistically significant ORs of just over 1. (4) Conclusions: Although the measured values are, on average, within the reference level, prevention measures must be implemented, as the measured radon values allow us to estimate an expected value of 3.66 cases of lung cancer per 10,000 people in the resident population.

Indoor radon exposure and excess of lung cancer mortality: the case of Mexico—an ecological study

2020 ◽  
Author(s):  
G. Ponciano-Rodríguez ◽  
M. I. Gaso ◽  
M. A. Armienta ◽  
C. Trueta ◽  
I. Morales ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Mortality ◽  
Ecological Study ◽  
Indoor Radon ◽  
Lung Cancer Mortality ◽  
Radon Exposure
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