scholarly journals The prevalence and natural history of aortic aneurysms in heart and abdominal organ transplant patients

2003 ◽  
Vol 37 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Michael J. Englesbe ◽  
Audrey H. Wu ◽  
Alexander W. Clowes ◽  
R.Eugene Zierler
Keyword(s):  
Natural History ◽  
Organ Transplant ◽  
Aortic Aneurysms ◽  
Abdominal Organ ◽  
Transplant Patients ◽  
History Of

Effects of long-term chloroquine administration on the natural history of aortic aneurysms in mice

2015 ◽  
Vol 93 (8) ◽  
pp. 641-648 ◽  
Author(s):  
Azza Ramadan ◽  
Mark D. Wheatcroft ◽  
Adrian Quan ◽  
Krishna K. Singh ◽  
Fina Lovren ◽  
...  
Keyword(s):  
Natural History ◽  
Thrombus Formation ◽  
Aortic Aneurysms ◽  
Ang Ii ◽  
Abdominal Aortic ◽  
Suprarenal Aorta ◽  
History Of ◽  
Categorical Distribution

Autophagy regulates cellular homeostasis and integrates the cellular pro-survival machinery. We investigated the role of autophagy in the natural history of murine abdominal aortic aneurysms (AAA). ApoE−/− mice were implanted with saline- or angiotensin II (Ang-II)-filled miniosmotic pumps then treated with either the autophagy inhibitor chloroquine (CQ; 50 mg·(kg body mass)–1·day–1, by intraperitoneal injection) or saline. Ang-II-elicited aneurysmal expansion of the suprarenal aorta coupled with thrombus formation were apparent 8 weeks later. CQ had no impact on the incidence (50% for Ang-II compared with 46.2% for Ang-II + CQ; P = NS) and categorical distribution of aneurysms. The markedly reduced survival rate observed with Ang-II (57.1% for Ang-II compared with 100% for saline; P < 0.05) was unaffected by CQ (61.5% for Ang-II + CQ; P = NS compared with Ang-II). CQ did not affect the mean maximum suprarenal aortic diameter (1.91 ± 0.19 mm for Ang-II compared with 1.97 ± 0.21 mm for Ang-II + CQ; P = NS). Elastin fragmentation, collagen accumulation, and smooth muscle attrition, which were higher in Ang-II-treated mice, were unaffected by CQ treatment. Long-term CQ administration does not affect the natural history and prognosis of experimental AAA, suggesting that global loss of autophagy is unlikely to be a causal factor in the development of aortic aneurysms. Manipulation of autophagy as a mechanism to reduce AAA may need re-evaluation.

scholarly journals Natural history of vascular calcification in dialysis and transplant patients

2004 ◽  
Vol 19 (9) ◽  
pp. 2387-2393 ◽  
Author(s):  
S. M. Moe ◽  
K. D. O'Neill ◽  
M. Resterova ◽  
N. Fineberg ◽  
S. Persohn ◽  
...  
Keyword(s):  
Natural History ◽  
Vascular Calcification ◽  
Transplant Patients ◽  
History Of
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