scholarly journals Doxycycline in patients with abdominal aortic aneurysms and in mice: Comparison of serum levels and effect on aneurysm growth in mice

2002 ◽  
Vol 35 (5) ◽  
pp. 923-929 ◽  
Author(s):  
Amy K. Prall ◽  
G.Matthew Longo ◽  
William G. Mayhan ◽  
Eugene A. Waltke ◽  
Beverly Fleckten ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysms ◽  
Serum Levels ◽  
Aortic Aneurysms ◽  
Abdominal Aortic ◽  
Aneurysm Growth

Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms

2007 ◽  
Vol 98 (08) ◽  
pp. 427-433 ◽  
Author(s):  
Chaoyong Zhu ◽  
Angela Silveira ◽  
Anne-Louise Hemdahl ◽  
Anders Hamsten ◽  
Ulf Hedin ◽  
...  
Keyword(s):  
Elective Surgery ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Intraluminal Thrombus ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Reducing Conditions ◽  
Aneurysm Wall ◽  
Abdominal Aortic ◽  
Aneurysm Growth ◽  
Neutrophil Gelatinase

SummaryIt has been suggested that the intraluminal thrombus of abdominal aortic aneurysms (AAAs) predisposes for AAA enlargement and rupture.The growth of theAAA is dependent on proteolytic degradation of elastin. Here, we analysed whether the neutrophil gelatinase-associated lipocalin (NGAL) is expressed within the thrombus and the aneurysm wall. NGAL can bind to metalloproteinase- 9 (MMP-9) and inhibit its degradation,thereby preserving enzymatic activity. Biopsies were obtained from thrombus- free and thrombus-covered aneurysm wall and the intraluminal thrombus from patients undergoing elective surgery for AAA. Immunohistochemistry and real-time PCR were used to study NGAL and MMP-9 expression. Immunoprecipitation, gel zymography,Western blot and ELISA were used to detect and quantify NGAL/MMP-9 complexes. NGAL was detected in the thrombus, the interface between the thrombus and the underlying wall and in the wall itself.Double staining showed that neutrophils are the major source of NGAL expression. Immunoprecipitation of MMP-9 with antibody against NGAL showed that complexes of NGAL and active MMP-9 were present in thrombus, the interface fluid and the aneurysm wall.Western blot analyses using non-reducing conditions and gel zymography demonstrated that high-molecular-weight complexes of NGAL/MMP-9 were present within the different regions.The concentration of the NGAL/MMP-9 complex was highest in the luminal part of the thrombus. In conclusion, NGAL in complex with activated MMP-9 is present in AAA wall and thrombus. Neutrophil-derived NGAL could enhance the proteolytic activity associated with AAA, but the importance of this mechanism for aneurysm growth remains to be shown.

scholarly journals Development of a Novel Index to Characterise Arterial Dynamics Using Ultrasound Imaging

2020 ◽  
Author(s):  
Joel Ward ◽  
Xinghao Cheng ◽  
Yingyi Xiao ◽  
Pierfrancesco Lapolla ◽  
Anirudh Chandrashekar ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Ultrasound Imaging ◽  
Brachial Artery ◽  
Abdominal Aortic Aneurysms ◽  
Physical Characteristics ◽  
Aortic Aneurysms ◽  
Abdominal Aortic ◽  
Flow Mediated Dilatation ◽  
Aneurysm Growth ◽  
Relaxation Index

AbstractAbdominal aortic aneurysms (AAA) are associated with systemic inflammation and endothelial dysfunction. We previously reported flow mediated dilatation (FMD) of the brachial artery as a predictor of AAA growth. We hence hypothesised that other physical characteristics of the brachial artery correlate with AAA growth. Using a prospectively cohort of AAA patients, we devised a ‘brachial artery relaxation index’ (BARI) and examined its role as a biomarker for AAA growth. However, no correlation between BARI and future aneurysm growth was observed (p=0.5). Therefore, our investigations did not substantiate the hypothesis that other physical characteristics of the brachial artery predicts AAA growth.

Real-Time Measurement of Multi-Component Velocity Vectors Within Abdominal Aortic Aneurysms Using Echo PIV: Comparison of In Vitro and Computational Results

2007 ◽  
Author(s):  
Lingli Liu ◽  
Fuxing Zhang ◽  
Rui Wang ◽  
Robin Shandas
Keyword(s):  
Disease Process ◽  
Abdominal Aortic Aneurysms ◽  
The United States ◽  
Aneurysm Rupture ◽  
Aortic Aneurysms ◽  
Non Invasive ◽  
Abdominal Aortic ◽  
Component Velocity ◽  
Aneurysm Growth

Abdominal aortic aneurysms (AAAs) are localized balloon-shaped expansions commonly found in the infrarenal segment of the abdominal aorta, between the renal arteries and the iliac bifurcation. Abdominal aortic aneurysm rupture has been estimated to occur in as much as 3%–9% of the population, and represents the 13th leading cause of death in the United States, producing more than 10,000 deaths annually [1]. Thus, determining the significant factors for aneurysm growth and rupture has become an important clinical goal. From a biomechanical standpoint, AAA rupture risk is related to certain mechanical and hemodynamic factors such as localized flow fields and velocity patterns, and flow-induced stresses within the fluid and in the aneurysm structure [2]. Disturbed flow patterns at different levels have also been found to trigger responses within medial and adventitial layers by altering intercellular communication mechanisms. Thus, localized hemodynamics proximal, within and distal to AAA formations play an important role in modulating the disease process, and non-invasive and easy-to-implement methods to characterize and quantify these complex hemodynamics would be tremendously useful.

CT textural analysis of abdominal aortic aneurysms as a biomarker for aneurysm growth

The Lancet ◽  
2014 ◽  
Vol 383 ◽  
pp. S87 ◽  
Author(s):  
Nikil K Rajani ◽  
Nikhil V Joshi ◽  
Maysoon Elkhawad ◽  
Adam Melville ◽  
Mohammed Chowdhury ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysms ◽  
Textural Analysis ◽  
Aortic Aneurysms ◽  
Abdominal Aortic ◽  
Aneurysm Growth

scholarly journals Development of a novel index to characterise arterial dynamics using ultrasound imaging

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248043
Author(s):  
Joel Ward ◽  
Xinghao Cheng ◽  
Yingyi Xiao ◽  
Pierfrancesco Lapolla ◽  
Anirudh Chandrashekar ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Ultrasound Imaging ◽  
Brachial Artery ◽  
Abdominal Aortic Aneurysms ◽  
Physical Characteristics ◽  
Aortic Aneurysms ◽  
Abdominal Aortic ◽  
Flow Mediated Dilatation ◽  
Aneurysm Growth ◽  
Relaxation Index

Abdominal aortic aneurysms (AAA) are associated with systemic inflammation and endothelial dysfunction. We previously reported flow mediated dilatation (FMD) of the brachial artery as a predictor of AAA growth. We hence hypothesised that other physical characteristics of the brachial artery correlate with AAA growth. Using a prospectively cohort of AAA patients, we devised a ‘brachial artery relaxation index’ (BARI) and examined its role as a biomarker for AAA growth. However, no correlation between BARI and future aneurysm growth was observed (p = 0.45). Therefore, our investigations did not substantiate the hypothesis that other physical characteristics of the brachial artery predicts AAA growth.

Perigraft hygroma – a rare cause of post-EVAR aneurysm growth

VASA ◽  
2017 ◽  
Vol 46 (6) ◽  
pp. 490-493 ◽  
Author(s):  
Nicholas Strouther ◽  
Olufemi Oshin ◽  
Robert Fisher ◽  
Richard McWilliams ◽  
Francesco Torella
Keyword(s):  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Abdominal Aortic ◽  
Aneurysm Growth

Abstract. Development of perigraft hygromas following repair of abdominal aortic aneurysms is extremely rare. A case is presented of a patient who was found to have a large hygroma despite two re-interventions on a previous EVAR.

scholarly journals Diabetic Patients with Small Abdominal Aortic Aneurysms Have Slower Aneurysm Growth Without Differences in Inflammatory Markers

2021 ◽  
Vol 73 (1) ◽  
pp. e16-e17
Author(s):  
Matthew Nordness ◽  
Bernard T. Baxter ◽  
Jon Matsumura ◽  
Michael Terrin ◽  
Nancy Webb ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Diabetic Patients ◽  
Abdominal Aortic ◽  
Aneurysm Growth

scholarly journals Effect of Doxycycline on Aneurysm Growth Among Patients With Small Infrarenal Abdominal Aortic Aneurysms

JAMA ◽  
2020 ◽  
Vol 323 (20) ◽  
pp. 2029 ◽  
Author(s):  
B. Timothy Baxter ◽  
Jon Matsumura ◽  
John A. Curci ◽  
Ruth McBride ◽  
LuAnn Larson ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Abdominal Aortic ◽  
Aneurysm Growth
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