scholarly journals Localization of nitric oxide synthase in saphenous vein grafts harvested with a novel “no-touch” technique: Potential role of nitric oxide contribution to improved early graft patency rates

2002 ◽  
Vol 35 (2) ◽  
pp. 356-362 ◽  
Author(s):  
Janice C.S. Tsui ◽  
Domingos S.R. Souza ◽  
Derek Filbey ◽  
Mats G. Karlsson ◽  
Michael R. Dashwood
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Saphenous Vein ◽  
Potential Role ◽  
Graft Patency ◽  
Vein Grafts ◽  
Saphenous Vein Grafts ◽  
Early Graft ◽  
Oxide Synthase

Role of hydrogen peroxide in ACh-induced dilation of human submucosal intestinal microvessels

2005 ◽  
Vol 288 (1) ◽  
pp. H48-H54 ◽  
Author(s):  
Ossama A. Hatoum ◽  
David G. Binion ◽  
Hiroto Miura ◽  
Gordon Telford ◽  
Mary F. Otterson ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Potential Role ◽  
Bowel Function ◽  
Cyclooxygenase Inhibitors ◽  
P450 Monooxygenase ◽  
Oxide Synthase ◽  
Dose Dependent ◽  
Endothelium Dependent Relaxation

The endothelium plays an important role in maintaining vascular homeostasis by synthesizing and releasing several mediators of vasodilation, which include prostacyclin (PGI2), nitric oxide, and endothelium-derived hyperpolarizing factor (EDHF). We have recently defined the role of nitric oxide and PGI2 in the dilation of submucosal intestinal arterioles from patients with normal bowel function. However, significant endothelium-dependent dilator capacity to ACh remained after inhibiting both these mediators. The current study was designed to examine the potential role of EDHF in human intestinal submucosal arterioles. ACh elicited endothelium-dependent relaxation in the presence of inhibitors of nitric oxide synthase and cyclooxygenase (23 ± 10%, n = 6). This ACh-induced relaxation was inhibited and converted to constriction by catalase (−53 ± 10%, n = 6) or KCl (−30 ± 3%, n = 7), whereas 17-octadecynoic acid and 6-(2-propargylloxyphenyl) hexanoic acid, two inhibitors of cytochrome P450 monooxygenase, had no significant effect (3 ± 1% and 20 ± 8%, n = 5, respectively). Exogenous H2O2 elicited dose-dependent relaxation of intact microvessels (52 ± 10%, n = 7) but caused frank vasoconstriction in arterioles denuded of endothelium (−73 ± 8%, n = 7). ACh markedly increased the dichlorofluorescein fluorescence in intact arterioles in the presence of nitric oxide synthase and cyclooxygenase inhibitors compared with control and compared with catalase-treated microvessels (363.6 ± 49, 218.8 ± 10.6, 221.9 ± 27.9, respectively, P < 0.05 ANOVA, n = 5 arbitrary units). No changes in the dichlorofluorescein fluorescence were recorded in vessels treated with ACh alone. These results indicate that endothelial production of H2O2 occurs in response to ACh in human gut mucosal arterioles but that H2O2 is not an EDHF in this tissue. Rather, we speculate that it stimulates the release of a chemically distinct EDHF.

Potential role of nitric oxide synthase isoforms in pathophysiology of neuropathic pain

2014 ◽  
Vol 22 (5) ◽  
pp. 269-278 ◽  
Author(s):  
Abhilasha Ahlawat ◽  
Ajay Rana ◽  
Nidhi Goyal ◽  
Saurabh Sharma
Keyword(s):  
Nitric Oxide ◽  
Neuropathic Pain ◽  
Nitric Oxide Synthase ◽  
Potential Role ◽  
Oxide Synthase

scholarly journals (-)-Epicatechin-induced recovery of mitochondria from simulated diabetes: Potential role of endothelial nitric oxide synthase

2016 ◽  
Vol 13 (3) ◽  
pp. 201-210 ◽  
Author(s):  
Israel Ramírez-Sánchez ◽  
Alonso Rodríguez ◽  
Aldo Moreno-Ulloa ◽  
Guillermo Ceballos ◽  
Francisco Villarreal
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Potential Role ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide
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