scholarly journals Expression of heat shock protein–70 by dendritic cells in the arterial intima and its potential significance in atherogenesis

2002 ◽  
Vol 35 (2) ◽  
pp. 368-375 ◽  
Author(s):  
Yuri V. Bobryshev ◽  
Reginald S.A. Lord
Keyword(s):  
Dendritic Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Potential Significance ◽  
Arterial Intima

scholarly journals Human recombinant heat shock protein 70 affects the maturation pathways of dendritic cells in vitro and has an in vivo adjuvant activity

2008 ◽  
Vol 84 (1) ◽  
pp. 199-206 ◽  
Author(s):  
Barbara Valentinis ◽  
Annalisa Capobianco ◽  
Francesca Esposito ◽  
Alessandro Bianchi ◽  
Patrizia Rovere-Querini ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Adjuvant Activity

scholarly journals Heat shock protein 70 from Trichinella spiralis induces protective immunity in BALB/c mice by activating dendritic cells

Vaccine ◽  
2014 ◽  
Vol 32 (35) ◽  
pp. 4412-4419 ◽  
Author(s):  
Lei Fang ◽  
Liang Sun ◽  
Jing Yang ◽  
Yuan Gu ◽  
Bin Zhan ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Protective Immunity ◽  
Trichinella Spiralis

scholarly journals Inducible Heat Shock Protein 70 Reduces T Cell Responses and Stimulatory Capacity of Monocyte-derived Dendritic Cells

2012 ◽  
Vol 287 (15) ◽  
pp. 12387-12394 ◽  
Author(s):  
Pawel Stocki ◽  
Xiao N. Wang ◽  
Anne M. Dickinson
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
T Cell Responses ◽  
Inflammatory Reactions ◽  
Cell Responses ◽  
Immature Dendritic Cells

Heat shock protein 70 (Hsp70) has gained a lot of attention in the past decade due to its potential immunoregulatory functions. Some of the described proinflammatory functions of Hsp70 became controversial as they were based on recombinant Hsp70 proteins specimens, which were later shown to be endotoxin-contaminated. In this study we used low endotoxin inducible Hsp70 (also known as Hsp72, HSPA1A), and we observed that after a 24-h incubation of monocyte-derived immature dendritic cells (mo-iDCs) with 20 μg/ml of low endotoxin Hsp70, their ability to stimulate allogenic T cells was reduced. Interestingly, low endotoxin Hsp70 also significantly reduced T cell responses when they were simulated with either IL-2 or phytohemagglutinin, therefore showing that Hsp70 could alter T cell responses independently from its effect on mo-iDCs. We also reported a greater response of Hsp70 treatment when activated versus nonactivated T cells were used. This effect of Hsp70 was similar for all tested populations of T cells that included CD3+, CD4+, or CD8+. Taken together, our observations strongly suggest that Hsp70 might dampen, rather than provoke, T cell-mediated inflammatory reactions in many clinical conditions where up-regulation of Hsp70 is observed.

scholarly journals Tumor-Derived Heat Shock Protein 70 Peptide Complexes Are Cross-Presented by Human Dendritic Cells

2002 ◽  
Vol 169 (10) ◽  
pp. 5424-5432 ◽  
Author(s):  
Elfriede Noessner ◽  
Robert Gastpar ◽  
Valeria Milani ◽  
Anna Brandl ◽  
Peter J. S. Hutzler ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Peptide Complexes ◽  
Human Dendritic Cells

Toxoplasma gondii-derived heat shock protein 70 stimulates the maturation of human monocyte-derived dendritic cells

2004 ◽  
Vol 322 (3) ◽  
pp. 899-904 ◽  
Author(s):  
Hyun Kyu Kang ◽  
Ha-Young Lee ◽  
Youl-Nam Lee ◽  
Eun Jin Jo ◽  
Jung Im Kim ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Heat Shock ◽  
Toxoplasma Gondii ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Human Monocyte
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