scholarly journals Association of the 4G/5G polymorphism in the promoter region of plasminogen activator inhibitor-1 with abdominal aortic aneurysms

2000 ◽  
Vol 31 (5) ◽  
pp. 1026-1032 ◽  
Author(s):  
Jeremy I. Rossaak ◽  
André M. van Rij ◽  
Gregory T. Jones ◽  
Eugenie L. Harris
Keyword(s):  
Plasminogen Activator ◽  
Promoter Region ◽  
Plasminogen Activator Inhibitor ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Plasminogen Activator Inhibitor 1 ◽  
Abdominal Aortic ◽  
Activator Inhibitor

scholarly journals Plasminogen activator inhibitor-1 plasma level increases with age in subjects with the 4G allele at position -675 in the promoter region

2004 ◽  
Vol 92 (11) ◽  
pp. 1164-1165 ◽  
Author(s):  
Cristina Sirolla ◽  
Stefano Cenerelli ◽  
Maurizio Marra ◽  
Massimo Boemi ◽  
Claudio Franceschi ◽  
...  
Keyword(s):  
Plasma Level ◽  
Plasminogen Activator ◽  
Promoter Region ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Activator Inhibitor

Intraluminal Thrombus Enhances Proteolysis in Abdominal Aortic Aneurysms

Vascular ◽  
2006 ◽  
Vol 14 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Tom W.G. Carrell ◽  
Kevin G. Burnand ◽  
Nuala A. Booth ◽  
Julia Humphries ◽  
Alberto Smith
Keyword(s):  
Plasminogen Activator ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Plasmin Activity ◽  
Plasminogen Activator Inhibitor 1 ◽  
Intraluminal Thrombus ◽  
Aneurysm Wall ◽  
Abdominal Aortic ◽  
Significant Difference ◽  
Pai 1

This study examined whether intraluminal thrombus in abdominal aortic aneurysms (AAAs) is a source of fibrinolytic activity and proteolysis that could weaken the aneurysm wall. Plasmin, tissue plasminogen activator (tPA), and urokinase plasminogen activator (uPA) activity, plasminogen activator inhibitor 1 (PAI-1), and α2-antiplasmin (α2AP) antigen were measured in the AAA wall and juxtamural and luminal aspects of intraluminal thrombus in 18 patients. The aneurysm wall contained 100-fold higher tPA activity (1.06 ± 0.34 [standard error of measurement] U/mg soluble protein) compared with juxtamural thrombus (JMT) (0.011 ± 0.001 ) and luminal thrombus (LT) (0.01 ± 0.001) ( p < .00001) and over 6-fold higher uPA activity (29.3 ± 3.4 IU/mg compared with the JMT (4.3 ± 2.4, p = .00024) and LT (7.9 ± 1.76, p = .0005). The LT had significantly lower levels of PAI-1 (1.26 ± 0.34 ng/mg) than the AAA wall (2.08 ± 0.51, p = .04) and the JMT (3.94 ± 0.85, p = .007). The levels of α2AP in the wall (19.4 ± 3.1 ng/mg) were lower than in the JMT or LT (43.0 ± 7.9 ng/mg, p = .013, and 47.6 ± 6.0 ng/mg, p = .002, respectively). There was no significant difference, however, in plasmin activity among the AAA wall, JMT, and LT. There were significant amounts of latent gelatinase B (matrix metalloproteinase [MMP]-9) in the AAA, JMT, and LT. Mean levels of activated MMP-9 activity were similar in the AAA, JMT, and LT. Plasmin activation of MMPs at the interface between intraluminal thrombus and the aneurysm wall may enhance proteolysis and accelerate aneurysm expansion.

High levels of homocysteine, lipoprotein (a) and plasminogen activator inhibitor-1 are present in patients with abdominal aortic aneurysm

2005 ◽  
Vol 94 (11) ◽  
pp. 1094-1098 ◽  
Author(s):  
Rossella Marcucci ◽  
Betti Giusti ◽  
Giovanni Pratesi ◽  
Barbara Lari ◽  
Ilaria Sestini ◽  
...  
Keyword(s):  
Risk Factors ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Factor V Leiden Mutation ◽  
Lipoprotein A ◽  
Abdominal Aortic ◽  
Significant Difference ◽  
Activator Inhibitor ◽  
Pai 1

SummaryOver the last few years, there has been increasing interest in the investigation of the pathogenesis of AAA, and a role for some novel risk factors, in particular thrombophilic risk factors, has been suggested. The aim of this study was to evaluate a number of thrombophilic parameters in a large group of patients with AAA. In 438 patients with AAA, and in 438 healthy subjects, selected to be comparable for age and gender with patients and without instrumental evidence of AAA, a pattern of thrombophilic parameters [homocysteine (Hcy), lipoprotein (a) [Lp(a)], plasminogen activator inhibitor-1 (PAI-1), anticardiolipin antibodies (ACA), MTHFR C677T polymorphism, prothrombin gene G20210A variant and Factor V Leiden mutation] has been evaluated. A significant difference for Hcy, PAI-1 and Lp(a) plas-After adjustment for the traditional cardiovascular risk factors, a significant increased risk of having AAA has been observed for high levels of Hcy (OR: 7.8; p<0.0001), Lp(a) (OR: 2.4; p<0.0001) and PAI-1 (OR:3.2;p<0.0001). The association has been confirmed after exclusion of patients with other localization of atherosclerosis. Moreover, a significant association between larger abdominal aortic diameters and the number of thrombophilic parameters has been reported (r = 0.13; p = 0.005). In conclusion, a significant association between abnormal levels of some metabolic parameters related to thrombosis such as Hcy, Lp(a) and PAI-1 and AAA has been observed.

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