Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower limb ischemia: Dose-response effect of basic fibroblast growth factor

1992 ◽  
Vol 16 (2) ◽  
pp. 0181-0191 ◽  
Author(s):  
Anthony M. Imparato ◽  
Richard M. Baffour ◽  
Joel M. Berman ◽  
Jane L. Garb ◽  
Sang Won Rhee ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Lower Limb ◽  
Rabbit Model ◽  
Limb Ischemia ◽  
Fibroblast Growth ◽  
Dose Response Effect ◽  
In Vivo Administration

scholarly journals Enhanced angiogenesis by gelatin hydrogels incorporating basic fibroblast growth factor in rabbit model of hind limb ischemia

2007 ◽  
Vol 22 (2) ◽  
pp. 104-108 ◽  
Author(s):  
Kazuhiko Doi ◽  
Tadashi Ikeda ◽  
Akira Marui ◽  
Toshihiro Kushibiki ◽  
Yoshio Arai ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Hind Limb ◽  
Rabbit Model ◽  
Limb Ischemia ◽  
Fibroblast Growth ◽  
Hind Limb Ischemia

Vascular Regeneration by Repeated Infusions of Basic Fibroblast Growth Factor in a Rabbit Model of Hind-Limb Ischemia

2009 ◽  
Vol 192 (6) ◽  
pp. W306-W310 ◽  
Author(s):  
Ayumi Seko ◽  
Norihisa Nitta ◽  
Akinaga Sonoda ◽  
Shinichi Ohta ◽  
Masashi Takahashi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Hind Limb ◽  
Rabbit Model ◽  
Limb Ischemia ◽  
Fibroblast Growth ◽  
Hind Limb Ischemia ◽  
Vascular Regeneration

Evaluation of the bioactivity about anti-sca-1/basic fibroblast growth factor-urinary bladder matrix scaffold for pelvic reconstruction

2018 ◽  
Vol 33 (6) ◽  
pp. 808-818 ◽  
Author(s):  
Jiankui Li ◽  
Xi Chen ◽  
Kaijian Ling ◽  
Zhiqing Liang ◽  
Huicheng Xu
Keyword(s):  
Growth Factor ◽  
Urinary Bladder ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Pelvic Organ ◽  
Fibroblast Growth ◽  
Pelvic Reconstruction ◽  
Urinary Bladder Matrix

Introduction and hypothesis: Pelvic support structure injury is the major cause of pelvic organ prolapse. At present, polypropylene-based filler material has been suggested as a common method to treat pelvic organ prolapse. However, it cannot functionally rehabilitate the pelvic support structure. In addition to its poor long-term efficiency, the urinary bladder matrix was the most suitable biological scaffold material for pelvic floor repair. Here, we hypothesize that anti-sca-1 monoclonal antibody and basic fibroblast growth factor were cross-linked to urinary bladder matrix to construct a two-factor bioscaffold for pelvic reconstruction. Methods Through a bispecific cross-linking reagent, sulfosuccinimidyl 4-[N-maleimidomethyl] cyclohexane-1-carboxylate (sulfo-smcc) immobilized anti-sca-1 and basic fibroblast growth factor to urinary bladder matrix. Then scanning electron microscope and plate reader were used to detect whether the anti-sca-1/basic fibroblast growth factor-urinary bladder matrix scaffold was built successfully. After that, the capacity of enriching sca-1 positive cells was measured both in vitro and in vivo. In addition, we evaluated the differentiation capacity and biocompatibility of the scaffold. Finally, western blotting was used to detect the level of fibulin-5 protein. Results The scanning electron microscope and plate reader revealed that the double-factor biological scaffold was built successfully. The scaffold could significantly enrich a large number of sca-1 positive cells both in vitro and in vivo, and obviously accelerate cells and differentiate functional tissue with good biocompatibility. Moreover, the western blotting showed that the scaffold could improve the expression of fibulin-5 protein. Conclusion The anti-sca-1/basic fibroblast growth factor-urinary bladder matrix scaffold revealed good biological properties and might serve as an ideal scaffold for pelvic reconstruction.

Induction of activin A is essential for the neuroprotective action of basic fibroblast growth factor in vivo

10.1038/77548 ◽  
2000 ◽  
Vol 6 (7) ◽  
pp. 812-815 ◽  
Author(s):  
Yvonne P. Tretter ◽  
Moritz Hertel ◽  
Barbara Munz ◽  
Gerrit ten Bruggencate ◽  
Sabine Werner ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Activin A ◽  
Fibroblast Growth ◽  
Neuroprotective Action
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