scholarly journals Blood cardioplegia supplementation with the sodium-hydrogen ion exchange inhibitor cariporide to attenuate infarct size and coronary artery endothelial dysfunction after severe regional ischemia in a canine model

2003 ◽  
Vol 125 (1) ◽  
pp. 155-164 ◽  
Author(s):  
Satoshi Muraki ◽  
Cullen D. Morris ◽  
Jason M. Budde ◽  
Zhi-Qing Zhao ◽  
Robert A. Guyton ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Endothelial Dysfunction ◽  
Ion Exchange ◽  
Infarct Size ◽  
Canine Model ◽  
Hydrogen Ion ◽  
Blood Cardioplegia ◽  
Regional Ischemia ◽  
Exchange Inhibitor ◽  
Sodium Hydrogen

Adenosine-Supplemented Blood Cardioplegia Attenuates Postischemic Dysfunction After Severe Regional Ischemia

Circulation ◽  
1999 ◽  
Vol 100 (suppl_2) ◽  
Author(s):  
Vinod H. Thourani ◽  
Russell S. Ronson ◽  
David G.L. Van Wylen ◽  
Steven T. Shearer ◽  
Sara L. Katzmark ◽  
...  
Keyword(s):  
At Risk ◽  
Coronary Artery ◽  
Infarct Size ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Area At Risk ◽  
Blood Cardioplegia ◽  
Regional Ischemia ◽  
Myocardial Area ◽  
Group 5

Background —Various studies have reported that the administration of adenosine (ADO) in cardioplegia reduces myocardial ischemic injury, but this timing may not utilize ADO’s potential against myocardial reperfusion injury. This study tested the hypothesis that ADO-supplemented blood cardioplegia (BCP) or ADO administered during reperfusion reduces postischemic dysfunction after severe regional ischemia. Methods and Results —After 75 minutes of left anterior descending coronary artery occlusion, total cardiopulmonary bypass was initiated; cold (4°C) antegrade BCP (8:1 blood:crystalloid) was delivered every 20 minutes for the first 3 doses, and 27°C BCP was delivered for the terminal infusion. Dogs (n=6 per group) received unsupplemented BCP, ADO (100 μmol/L/L) supplemented in all infusions of BCP (ADO-CP), or ADO (100 μmol · L −1 · L −1 ) supplemented only in the terminal infusion of BCP followed by intravenous ADO (140 μg · kg −1 · min −1 ) infusion for the first 30 minutes of reperfusion (ADO-R). Postischemic regional systolic shortening was significantly greater in the ADO-R group (5±2.0%) than in the BCP group (−3±1.0%), but not in the ADO-CP group (2±0.2%). Postischemic regional diastolic stiffness in the area at risk during end reperfusion was lower with ADO-R (1.8±0.3%) than with ADO-CP (2.7±0.3%) or BCP (4.4±0.5%). Infarct size was reduced in the ADO-CP (29±2%) and ADO-R (21±2%) groups compared with the BCP group (42±4%). Edema in the myocardial area at risk was decreased in the ADO-CP (82±0.2%) and ADO-R (80±0.4%) groups compared with the BCP group (86±0.7%). Adherence of fluorescently labeled neutrophils (PMNs) to postischemic coronary artery endothelium was attenuated by ADO-R (55±2 PMNs/mm 2 ), but not by ADO-CP (114±5 PMNs/mm 2 ), compared with BCP (118±3 PMNs/mm 2 ). Conclusions —The results show that BCP supplemented with ADO reduces infarct size, preserves postischemic systolic and diastolic regional function but does not attenuate coronary artery endothelial dysfunction unless administered during reperfusion.

scholarly journals Platelet sodium/hydrogen ion exchange in normal pregnancy and non-proteinuric pre-eclampsia

1997 ◽  
Vol 11 (7) ◽  
pp. 453-458 ◽  
Author(s):  
D Graham ◽  
JCP Kingdom ◽  
J McDonald ◽  
DL Davies ◽  
CJ Kenyon
Keyword(s):  
Ion Exchange ◽  
Normal Pregnancy ◽  
Hydrogen Ion ◽  
Sodium Hydrogen

Dispersion Attendant Sodium/ Hydrogen Ion Exchange in Reservoir Sands

1986 ◽  
Vol 1 (06) ◽  
pp. 607-610
Author(s):  
J.A. Jensen ◽  
J.V. Gillis ◽  
C.J. Radke
Keyword(s):  
Ion Exchange ◽  
Hydrogen Ion ◽  
Sodium Hydrogen

76 Sodium-hydrogen ion exchange in normal pregnancy and pregnancy-induced hypertension

1993 ◽  
Vol 11 (5) ◽  
pp. S430
Author(s):  
D. Graham ◽  
J. McDonald ◽  
J. Kingdom ◽  
D. L. Davies ◽  
C. J. Kenyon
Keyword(s):  
Ion Exchange ◽  
Normal Pregnancy ◽  
Hydrogen Ion ◽  
Pregnancy Induced Hypertension ◽  
Sodium Hydrogen ◽  
Induced Hypertension

PREPARATION OF ION-EXCHANGE RESINS

1954 ◽  
Vol 32 (2) ◽  
pp. 143-152 ◽  
Author(s):  
I. H. Spinner ◽  
J. Ciric ◽  
W. F. Graydon
Keyword(s):  
Ion Exchange ◽  
Sulphonic Acid ◽  
Hydrogen Ion ◽  
Ion Exchange Resins ◽  
Granular Form ◽  
Sodium Hydrogen ◽  
Group Environment ◽  
Subsequent Hydrolysis ◽  
Equilibrium Data ◽  
Exchange Resins

Ion-exchange resins as membranes and in granular form have been prepared by the copolymerization of divinylbenzene with various esters of p-styrene-sulphonic acid and subsequent hydrolysis. The synthesis of the sulphonated styrene monomers is described. Equilibrium data for the sodium–hydrogen ion exchange on a resin prepared in this manner are discussed in terms of postulated variations of sulphonate group environment.

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