The relation of alcohol consumption and cigarette smoking to the multiple occurrence of esophageal dysplasia and squamous cell carcinoma

Surgery ◽  
2002 ◽  
Vol 131 (1) ◽  
pp. S7-S13 ◽  
Author(s):  
Mitsuhiro Miyazaki ◽  
Shinji Ohno ◽  
Motonori Futatsugi ◽  
Hiroshi Saeki ◽  
Takefumi Ohga ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Alcohol Consumption ◽  
Cigarette Smoking ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Esophageal Dysplasia ◽  
Multiple Occurrence

scholarly journals Susceptibility to oral squamous cell carcinoma: correlation with variants of CYP1A1-MspI, GSTT1, GSTM1, ALDH2, EC-SOD and Lifestyle factors

2016 ◽  
Vol 19 (2) ◽  
pp. 61-70 ◽  
Author(s):  
T-T Dong ◽  
L-J Wang ◽  
L-Z Liu ◽  
S-N Ma
Keyword(s):  
Squamous Cell Carcinoma ◽  
Alcohol Consumption ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Information ◽  
Genotype Distribution ◽  
Drinking Habits ◽  
Genes Encoding ◽  
Drinking History

AbstractIn order to investigate the association between polymorphisms in genes encoding metabolizing enzymes (CYP1A1-MspI, EC-SOD (extracellular superoxide dismutase), GSTT1, GSTM1, ALDH2), cigarette and alcohol consumption, and the risk of oral squamous cell carcinoma, we conducted a prospective case-control study comprised of 750 individuals with oral squamous cell carcinoma (OSCC) and 750 healthy individuals. Data about smoking and drinking habits were collected along with other demographic and clinical information. Peripheral blood samples were collected for DNA extraction, and polymerase chain reaction (PCR) and PCR-RFLP (restriction fragment length polymorphism) were used to determine genotypes of CYP1A1, EC-SOD, GSTT1, GSTM1, ALDH2. The results showed that smoking and alcohol consumption were significantly more common among patients than controls (p <0.05). There were significant differences in the genotype distribution for each locus between groups, with the CYP1A1 (m2/ m2), EC-SOD (C/G), GSTT1 [–], GSTM1 [–] and ALDH2 (non G/G) genotypes being more common among patients (p <0.05). Furthermore, the majority of patients had at least two or more variant genotypes, while controls had one or no variant genotype (p <0.05). Finally, multiple variant genotypes combined with smoking, drinking, or both smoking and drinking significantly increased the risk of OSCC, with greater increase for heavier smoking/drinking. In brief, genetic polymorphism of CYP1A1, EC-SOD, GSTT1, GSTM1, and ALDH2 and smoking and drinking history are closely associated with susceptibility to OSCC.

scholarly journals Gender Differences in Oesophageal Squamous Cell Carcinoma in a South African Tertiary Hospital

2020 ◽  
Vol 17 (19) ◽  
pp. 7086
Author(s):  
Lucien Ferndale ◽  
Colleen Aldous ◽  
Richard Hift ◽  
Sandie Thomson
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Risk Factor ◽  
Alcohol Consumption ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Presentation ◽  
Tertiary Hospital ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Males And Females

(1) Oesophageal squamous cell carcinoma is common in Africa and has a male preponderance. The gender-based differences in clinical presentation and risk factor exposure are poorly studied in the African context. Our aim was to compare males and females with this disease. We analyzed the differences in clinical features and risk factor exposure between males and females with oesophageal cancer. (2) Data from patients presenting to a tertiary hospital in South Africa with oesophageal squamous cell carcinoma were analyzed. Data collected included patient demographics, clinical presentation, pathology and risk factor exposure. (3) Three hundred and sixty three patients were included in the study. The male to female ratio was 1.4:1. The mean age was 66 years for females and 61 years for males (p < 0.0001). A significantly larger percentage of males were underweight compared to females (60% vs. 32%, p < 0.001). There were no differences between the genders with regards to performance status, dysphagia grade and duration and tumor length, location and degree of differentiation. There were significant differences between risk factor exposure between the two genders. Smoking and alcohol consumption was an association in more than 70% of males but in less than 10% of females There was no difference survival. (4) Female patients with oesophageal squamous cell carcinoma (OSCC) are older and have a higher body mass index (BMI) than their male counterparts. Traditionally purported risk factors of smoking and alcohol consumption are infrequent associations with OSCC in female patients and other environmental risk factors may be more relevant in this gender.

scholarly journals Demography and Histologic Pattern of Laryngeal Squamous Cell Carcinoma in Kenya

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Owen Pyeko Menach ◽  
Asmeeta Patel ◽  
Herbert Ouma Oburra
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cigarette Smoking ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Alcohol Ingestion ◽  
Male Predominance ◽  
Increased Risk ◽  
Current Cigarette ◽  
Poorly Differentiated

Background. Laryngeal squamous cell carcinoma is a common head and neck cancer worldwide.Objective. To determine the demographic characteristics of patients with laryngeal cancer, establish their tumor characteristics and relate it to their smoking and alcohol ingestion habits.Methods. Fifty cases and fifty controls were recruited of matching age, sex, and region of residence. History and pattern of cigarette smoking and alcohol ingestion was taken and analyzed.Results. 33 (66%) of the cases and 3 (6%) among controls were current cigarette smokers. 74% had smoked for more than 30 years,P<0.0001OR 21.3 (95% CI: 2.6–176.1). There was a male predominance (96%) and most cases (62%) were from the ethnic communities in the highland areas of Kenya predominantly in Central and Eastern provinces. Very heavy drinkers had increased risk ofP<0.0001OR, 6.0 (95% CI: 1.957–18.398) and those who smoked cigarettes and drank alcohol had poorly differentiated tumors G3,P<0.001, OR 11.652 (95% CI 2.305–58.895), and G4,P=0.52OR 7.286 (95% CI 0.726–73.075). They also presented with advanced disease (73.6%).Conclusion. Cigarette smoking and alcohol ingestion are strong risk factors for development of late stage and poorly differentiated laryngeal squamous cell carcinoma in Kenya.

scholarly journals Prognostic value of p16 expression and alcohol consumption in Japanese patients with oropharyngeal squamous cell carcinoma

Cancer ◽  
2013 ◽  
Vol 119 (11) ◽  
pp. 2005-2011 ◽  
Author(s):  
Yuki Saito ◽  
Masafumi Yoshida ◽  
Tetsuo Ushiku ◽  
Go Omura ◽  
Yasuhiro Ebihara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Alcohol Consumption ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Japanese Patients ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
P16 Expression
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