Adenovirus vector-mediated transfer of the vascular endothelial growth factor cDNA to healing abdominal fascia enhances vascularity and bursting strength in mice with normal and impaired wound healing

Surgery ◽  
2002 ◽  
Vol 131 (2) ◽  
pp. 219-227 ◽  
Author(s):  
Maneesh Ailawadi ◽  
Jay M. Lee ◽  
Sang Lee ◽  
Neil Hackett ◽  
Ronald G. Crystal ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Wound Healing ◽  
Growth Factor ◽  
Adenovirus Vector ◽  
Vascular Endothelial ◽  
Impaired Wound Healing ◽  
Bursting Strength ◽  
Abdominal Fascia ◽  
Endothelial Growth Factor

scholarly journals Angelica dahurica and Rheum officinale Facilitated Diabetic Wound Healing by Elevating Vascular Endothelial Growth Factor

2021 ◽  
pp. 1-19
Author(s):  
Yuh-Huey Chao ◽  
Wan-Ting Yang ◽  
Ming-Chang Li ◽  
Fwu-Lin Yang ◽  
Ru-Ping Lee
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Wound Healing ◽  
Growth Factor ◽  
Smooth Muscle Actin ◽  
Intraperitoneal Administration ◽  
Angelica Dahurica ◽  
Vascular Endothelial ◽  
Sprague Dawley ◽  
Diabetic Wounds ◽  
Endothelial Growth Factor

Traditional Chinese medicine (TCM) provides alternative treatment choices for diabetic wounds. The aim of this study was to evaluate the effects of Angelica dahurica and Rheum officinale (ARE) on diabetic wounds and its underlying action mechanism. A total of 36 healthy male Sprague–Dawley rats were randomly divided into three groups: diabetes mellitus (DM) rats treated with ARE (DM-ARE), DM rats treated with 0.9% saline (DM-NS), and non-DM rats treated with 0.9% saline (NDM-NS). DM was induced by intraperitoneal administration of 40 mg/kg of streptozotocin after a 2-week high-fat diet feeding. After excisional skin wounds and treatments, the remaining wound area (RWA) in each group was measured. The RWA in the DM-NS group (69.60% ± 2.35%) was greater than that in the DM-ARE (55.70% ± 1.85%) and NDM-NS groups (52.50% ± 2.77%) on day 6. Besides, the DM-ARE group showed higher vascular endothelial growth factor (VEGF), higher inducible nitric oxide synthase (iNOs), higher [Formula: see text]-smooth muscle actin ([Formula: see text]-SMA), and lower nuclear factor kappa-light-chain-enhancer of activated B cell (NF-[Formula: see text]B) expression in the wound skin tissue. These results showed that treatment with ARE shifted the recovery pattern of diabetic rats to the pattern of nondiabetic rats, indicating that ARE may improve wound healing in diabetic conditions.

Safety of Direct Myocardial Administration of an Adenovirus Vector Encoding Vascular Endothelial Growth Factor 121

1999 ◽  
Vol 10 (8) ◽  
pp. 1331-1348 ◽  
Author(s):  
Shailen R. Patel ◽  
Leonard Y. Lee ◽  
Charles A. Mack ◽  
Dean R. Polce ◽  
Tarek El-Sawy ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Adenovirus Vector ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Loss of Vascular Endothelial Growth Factor A Activity in Murine Epidermal Keratinocytes Delays Wound Healing and Inhibits Tumor Formation

2004 ◽  
Vol 64 (10) ◽  
pp. 3508-3516 ◽  
Author(s):  
Heidemarie Rossiter ◽  
Caterina Barresi ◽  
Johannes Pammer ◽  
Michael Rendl ◽  
Jody Haigh ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Wound Healing ◽  
Growth Factor ◽  
Tumor Formation ◽  
Epidermal Keratinocytes ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Perlecan and vascular endothelial growth factor-encoding DNA-loaded chitosan scaffolds promote angiogenesis and wound healing

2017 ◽  
Vol 250 ◽  
pp. 48-61 ◽  
Author(s):  
Megan S. Lord ◽  
April L. Ellis ◽  
Brooke L. Farrugia ◽  
John M. Whitelock ◽  
Hernan Grenett ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Wound Healing ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Chitosan Scaffolds ◽  
Endothelial Growth Factor
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