Intensity of vascular endothelial growth factor expression is associated with increased risk of recurrence and decreased disease-free survival in papillary thyroid cancer

Surgery ◽  
2001 ◽  
Vol 129 (5) ◽  
pp. 552-558 ◽  
Author(s):  
Colleen M. Lennard ◽  
Aneeta Patel ◽  
John Wilson ◽  
Brian Reinhardt ◽  
Caroline Tuman ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Disease Free Survival ◽  
Vascular Endothelial ◽  
Papillary Thyroid ◽  
Free Survival ◽  
Increased Risk ◽  
Factor Expression ◽  
Growth Factor Expression ◽  
Endothelial Growth Factor ◽  
Disease Free

scholarly journals The role of vascular endothelial growth factor as a prognostic and clinicopathological marker in osteosarcoma: a systematic review and meta-analysis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Chao Zhang ◽  
Lin Wang ◽  
Chuang Xiong ◽  
Runhan Zhao ◽  
Hao Liang ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Overall Survival ◽  
Growth Factor ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Vascular Endothelial ◽  
Vegf Expression ◽  
Free Survival ◽  
Endothelial Growth Factor ◽  
Disease Free

Abstract Background In recent years, numerous investigations have been conducted to determine the clinical significance and critical functions of vascular endothelial growth factor (VEGF) in various malignant cancers. The purpose of this meta-analysis was to comprehensively evaluate the prognostic and clinicopathological value of VEGF in patients with osteosarcoma. Methods We performed a systematic literature retrieval of available databases. Odds ratios (ORs) or standard mean difference (SMD) for clinicopathological parameters, hazard ratios (HRs) for overall survival and disease-free survival were calculated to assess the correlation between VEGF expression and prognosis in patients with osteosarcoma. Results A total of 22 studies with 1144 patients were included in our study. Pooled analyses showed that VEGF overexpression predicted worse overall survival (HR, 2.42; 95% CI, 1.87–3.11, p < 0.001) and disease-free survival (HR, 2.604; 95% CI, 1.698–3.995, p < 0.001), respectively. Furthermore, investigation regarding osteosarcoma clinicopathologic characteristics suggested that high VEGF expression was significantly associated with metastasis (OR, 4.39; 95% CI, 2.77–6.95; p < 0.001), clinical stage (OR, 0.73; 95% CI, 0.62–0.87; p < 0.001), and microvessel density (SMD, 3.33, 95% CI,1.57–5.10, p < 0.001), but not associated with tumor location, gender, age, local recurrence, and chemotherapy response. Conclusion Our meta-analysis findings suggest that elevated VEGF expression may be a predictive biomarker for poor prognosis and adverse clinicopathological characteristics in patients with osteosarcoma.

Cytosol Vascular Endothelial Growth Factor in Endometrial Carcinoma: Correlation with Disease-Free Survival

2001 ◽  
Vol 80 (2) ◽  
pp. 207-212 ◽  
Author(s):  
Chi-An Chen ◽  
Wen-Fang Cheng ◽  
Chien-Nan Lee ◽  
Lin-Hung Wei ◽  
Jan-Show Chu ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Endometrial Carcinoma ◽  
Disease Free Survival ◽  
Vascular Endothelial ◽  
Free Survival ◽  
Endothelial Growth Factor ◽  
Disease Free

Prognostic Significance of Vascular Endothelial Growth Factor Protein Levels in Oral and Oropharyngeal Squamous Cell Carcinoma

2000 ◽  
Vol 18 (10) ◽  
pp. 2046-2052 ◽  
Author(s):  
Benjamin D. Smith ◽  
Grace L. Smith ◽  
Darryl Carter ◽  
Clarence T. Sasaki ◽  
Bruce G. Haffty
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Overall Survival ◽  
Squamous Cell ◽  
Disease Free Survival ◽  
Vascular Endothelial ◽  
Free Survival ◽  
Protein Levels ◽  
Endothelial Growth Factor ◽  
Disease Free ◽  
Vegf Protein

PURPOSE: Vascular Endothelial Growth Factor (VEGF) promotes angiogenesis in many different tumor types. VEGF levels may affect tumor growth, metastatic potential, and response to radiotherapy. This study assesses the prognostic value of VEGF protein levels in a cohort of patients with oral and oropharyngeal squamous cell carcinomas. The relationships between clinical outcome and the covariables of tumor-node-metastasis stage, disease stage (I to IV), grade, margin status, race, sex, and age were also determined. PATIENTS AND METHODS: Chart review identified 77 patients with oral or oropharyngeal squamous cell carcinoma treated with gross total surgical resection and postoperative radiation between 1981 and 1992. Sufficient follow-up data and tumor tissue were available in 56 patients (73%). VEGF protein levels were determined using immunohistochemistry. The association between VEGF status, covariables, and outcome was assessed in a bivariate and multivariate model using two-sided statistical tests. RESULTS: Twenty-three tumors (41%) were positive for VEGF expression. VEGF-positive tumors were more likely to recur locally (relative risk [RR] = 3.08; 95% confidence interval [CI], 1.03 to 9.24) and distantly (RR = 4.62; 95% CI, 1.41 to 15.10). In bivariate analysis, VEGF positivity was the most significant predictor of poor disease-free survival (RR = 2.66; 95% CI, 1.27 to 5.56) and overall survival (RR = 3.21; 95% CI, 1.63 to 6.32). In multivariate analysis, VEGF positivity was the most significant predictor of poor disease-free survival (RR = 2.75; 95% CI, 1.30 to 5.79) and overall survival (RR = 3.53; 95% CI, 1.75 to 7.13). CONCLUSION: In this cohort, VEGF positivity was the most significant predictor of poor prognosis. VEGF status may prove to be an important prognostic factor in head and neck cancer.

scholarly journals Increased vascular endothelial growth factor expression predicts a worse prognosis for laryngeal cancer patients: a meta-analysis

2016 ◽  
Vol 131 (1) ◽  
pp. 44-50 ◽  
Author(s):  
L-P Zhang ◽  
H-L Chen
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Overall Survival ◽  
Growth Factor ◽  
Laryngeal Cancer ◽  
Disease Free Survival ◽  
Vascular Endothelial ◽  
Free Survival ◽  
Hazard Ratios ◽  
Endothelial Growth Factor ◽  
Disease Free

AbstractObjective:This study assessed the relationship between vascular endothelial growth factor expression and the laryngeal cancer prognosis.Methods:Systematic computerised searches of PubMed were performed up to 31 January 2015. Prognostic endpoints were overall survival and disease-free survival. The pooled hazard ratios for overall survival and disease-free survival were also calculated.Results:Seven studies containing 975 patients were included. The pooled hazard ratio was 1.703 (95 per cent confidence interval, 1.373 to 2.112; z score = 4.85, p = 0.000) for overall survival and was 1.918 (95 per cent confidence interval, 1.410 to 2.609; z score = 4.15, p = 0.000) for disease-free survival. No significant publication bias was found. A sensitivity analysis showed that the results were robust. Power analyses also showed there was enough power to detect the calculated hazard ratios.Conclusion:The study found that vascular endothelial growth factor overexpression predicted a worse prognosis for laryngeal cancer patients. This supports a strategy of targeted therapy by blocking the vascular endothelial growth factor receptor.

Vascular Endothelial Growth Factor Expression in Invasive Papillary Thyroid Carcinoma

Thyroid ◽  
2009 ◽  
Vol 19 (11) ◽  
pp. 1233-1237 ◽  
Author(s):  
Vergilius José Furtado de Araujo-Filho ◽  
Venancio Avancini Ferreira Alves ◽  
Ines Vieira de Castro ◽  
Silvia Vanessa Lourenço ◽  
Claudio Roberto Cernea ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Vascular Endothelial ◽  
Papillary Thyroid ◽  
Factor Expression ◽  
Growth Factor Expression ◽  
Endothelial Growth Factor
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