Carcinoembryonic gene member 2 mRNA expression as a marker to detect circulating enterocytes in the blood of colorectal cancer patients

Surgery ◽  
2001 ◽  
Vol 129 (5) ◽  
pp. 587-594 ◽  
Author(s):  
Richard Douard ◽  
Valérie Le Maire ◽  
Philippe Wind ◽  
Jean-Patrick Sales ◽  
Frédéric Dumas ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mrna Expression ◽  
Cancer Patients ◽  
Colorectal Cancer Patients ◽  
Gene Member

High clusterin (CLU) mRNA expression levels in tumors of colorectal cancer patients predict a poor prognostic outcome

2020 ◽  
Vol 75 ◽  
pp. 62-69 ◽  
Author(s):  
Pinelopi I. Artemaki ◽  
Aimilia D. Sklirou ◽  
Christos K. Kontos ◽  
Aikaterini-Anna Liosi ◽  
Despoina D. Gianniou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mrna Expression ◽  
Cancer Patients ◽  
Expression Levels ◽  
Prognostic Outcome ◽  
Colorectal Cancer Patients ◽  
Mrna Expression Levels

scholarly journals Investigation of free cancer cells in peripheral blood using CEA mRNA expression in perioperative colorectal cancer patients

2013 ◽  
Vol 1 (4) ◽  
pp. 668-674 ◽  
Author(s):  
KIICHI NAGAYASU ◽  
HIROMITSU KOMIYAMA ◽  
SHUN ISHIYAMA ◽  
DAI OGURA ◽  
RINA TAKAHASHI ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mrna Expression ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Peripheral Blood ◽  
Cea Mrna ◽  
Colorectal Cancer Patients

Evaluation of thymidylate synthase and ERCC1 mRNA levels as predictive markers in colorectal cancer patients treated with S-1 and oxaliplatin

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e15071-e15071
Author(s):  
H. Kuramochi ◽  
K. Hayashi ◽  
G. Nakajima ◽  
H. Kamikozuru ◽  
M. Yamamoto
Keyword(s):  
Colorectal Cancer ◽  
Mrna Expression ◽  
Real Time ◽  
Cancer Patients ◽  
Thymidylate Synthase ◽  
Excision Repair ◽  
Mrna Levels ◽  
Expression Levels ◽  
Colorectal Cancer Patients ◽  
Mrna Expression Levels

e15071 Background: Oxaliplatin has been widely used for the treatment of colorectal cancer. The mechanism of action of platinum compounds such as oxaliplatin is to bind to a DNA molecule in the form of a platinum-DNA-adduct. Excision repair cross complementation group 1 (ERCC1), which plays a major role in the nucleotide excision pathway, has a polymorphism in codon 118, and is reported to be associated with a resistance to platinum-based therapy. Thymidylate synthase (TS) and dehydropyrimidine dehydrogenase (DPD) are key enzymes of 5-FU metabolism and are well known to be associated with a response to 5-FU-based therapy. Methods: Twenty-one colorectal cancer patients (male:female = 7:14; median age, 65) treated with a combination of oxaliplatin and S-1 as a first-line therapy were analyzed for ERCC1 codon 118 polymorphism and the mRNA expression levels of TS, ERCC1, and DPD. Formalin-fixed paraffin- embedded surgical specimens were used and t-RNA and DNA were extracted. The mRNA expression levels were measured using real-time RT-PCR, and the polymorphism was analyzed using the allelic discrimination method together with real-time PCR. Results: No correlation was observed between ERCC1 codon118 polymorphism and any response to the chemotherapy. ERCC1 mRNA levels tended to be higher in the patients with wild-type homozygous alleles in codon 118 than in those with at least one mutant allele(1.19 vs.0.68: p= 0.15). Patients with both high TS and ERCC1 mRNA levels showed a significantly lower response rate than the others (25% vs. 67%, p=0.02). No relationship was seen between DPD mRNA expression levels and the response. Conclusions: The mRNA expression levels of TS and ERCC1 appear to be useful markers for the treatment of S-1 and oxaliplatin. No particular usefulness of ERCC1 codon 118 polymorphism was verified. No significant financial relationships to disclose.

scholarly journals mRNA expression profiles in circulating tumor cells of metastatic colorectal cancer patients

2015 ◽  
Vol 9 (4) ◽  
pp. 920-932 ◽  
Author(s):  
Bianca Mostert ◽  
Anieta M. Sieuwerts ◽  
Joan Bolt-de Vries ◽  
Jaco Kraan ◽  
Zarina Lalmahomed ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Mrna Expression ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Expression Profiles ◽  
Colorectal Cancer Patients

Sonic hedgehog mRNA expression by real-time quantitative PCR in normal and tumor tissues from colorectal cancer patients

2006 ◽  
Vol 233 (1) ◽  
pp. 117-123 ◽  
Author(s):  
Mariano Monzo ◽  
Isabel Moreno ◽  
Rosa Artells ◽  
Rafael Ibeas ◽  
Alfons Navarro ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mrna Expression ◽  
Real Time ◽  
Cancer Patients ◽  
Quantitative Pcr ◽  
Sonic Hedgehog ◽  
Real Time Quantitative Pcr ◽  
Tumor Tissues ◽  
Colorectal Cancer Patients

Tumour CD133 mRNA expression and clinical outcome in surgically resected colorectal cancer patients

2010 ◽  
Vol 46 (3) ◽  
pp. 642-649 ◽  
Author(s):  
R. Artells ◽  
I. Moreno ◽  
T. Díaz ◽  
F. Martínez ◽  
B. Gel ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Outcome ◽  
Mrna Expression ◽  
Cancer Patients ◽  
Colorectal Cancer Patients
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