Antibiotic treatment-induced tubular dysfunction as a risk factor for renal stone formation in cystic fibrosis

2002 ◽  
Vol 140 (1) ◽  
pp. 103-109 ◽  
Author(s):  
Hansjosef Böhles ◽  
Boris Gebhardt ◽  
Thomas Beeg ◽  
Adrian C. Sewell ◽  
Eivind Solem ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Risk Factor ◽  
Antibiotic Treatment ◽  
Renal Stone ◽  
Stone Formation ◽  
Tubular Dysfunction

Renal Stone Formation in Primary Hyperparathyroidism — Role of Tubular Dysfunction

Urolithiasis ◽  
1981 ◽  
pp. 89-92 ◽  
Author(s):  
S. Ljunghall ◽  
B. G. Danielson ◽  
G. Johansson ◽  
L. Wibell
Keyword(s):  
Primary Hyperparathyroidism ◽  
Renal Stone ◽  
Stone Formation ◽  
Tubular Dysfunction

Which factors account for renal stone formation in cystic fibrosis?

2003 ◽  
Vol 59 (03) ◽  
pp. 160-163 ◽  
Author(s):  
R. von der Heiden ◽  
A.P.G. Balestra ◽  
M.G. Bianchetti ◽  
C. Casaulta Aebischer ◽  
P.E. Mullis ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Renal Stone ◽  
Stone Formation

scholarly journals URBANIZATION AS A RISK FACTOR FOR RENAL STONE FORMATION

2015 ◽  
Vol 21 (1) ◽  
pp. 90-94
Author(s):  
Ihsan S Sahi ◽  
Haithem Abd Al-Khazrajee
Keyword(s):  
Risk Factor ◽  
Renal Stone ◽  
Stone Formation

scholarly journals Inflammation in children with cystic fibrosis: contribution of bacterial production of long-chain fatty acids

2021 ◽  
Author(s):  
Erin Felton ◽  
Aszia Burrell ◽  
Hollis Chaney ◽  
Iman Sami ◽  
Anastassios C. Koumbourlis ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Fatty Acid ◽  
Antibiotic Treatment ◽  
Bacterial Production ◽  
Clinical Status ◽  
Achromobacter Xylosoxidans ◽  
List Type ◽  
Future Studies ◽  
Long Chain

Abstract Background Cystic fibrosis (CF) affects >70,000 people worldwide, yet the microbiologic trigger for pulmonary exacerbations (PExs) remains unknown. The objective of this study was to identify changes in bacterial metabolic pathways associated with clinical status. Methods Respiratory samples were collected at hospital admission for PEx, end of intravenous (IV) antibiotic treatment, and follow-up from 27 hospitalized children with CF. Bacterial DNA was extracted and shotgun DNA sequencing was performed. MetaPhlAn2 and HUMAnN2 were used to evaluate bacterial taxonomic and pathway relative abundance, while DESeq2 was used to evaluate differential abundance based on clinical status. Results The mean age of study participants was 10 years; 85% received combination IV antibiotic therapy (beta-lactam plus a second agent). Long-chain fatty acid (LCFA) biosynthesis pathways were upregulated in follow-up samples compared to end of treatment: gondoate (p = 0.012), oleate (p = 0.048), palmitoleate (p = 0.043), and pathways of fatty acid elongation (p = 0.012). Achromobacter xylosoxidans and Escherichia sp. were also more prevalent in follow-up compared to PEx (p < 0.001). Conclusions LCFAs may be associated with persistent infection of opportunistic pathogens. Future studies should more closely investigate the role of LCFA production by lung bacteria in the transition from baseline wellness to PEx in persons with CF. Impact Increased levels of LCFAs are found after IV antibiotic treatment in persons with CF. LCFAs have previously been associated with increased lung inflammation in asthma. This is the first report of LCFAs in the airway of persons with CF. This research provides support that bacterial production of LCFAs may be a contributor to inflammation in persons with CF. Future studies should evaluate LCFAs as predictors of future PExs.

scholarly journals Effect of Antibiotic Treatment on Bacteriophage Production by a Cystic Fibrosis Epidemic Strain ofPseudomonasaeruginosa

2010 ◽  
Vol 55 (1) ◽  
pp. 426-428 ◽  
Author(s):  
Joanne L. Fothergill ◽  
Eilidh Mowat ◽  
Martin J. Walshaw ◽  
Martin J. Ledson ◽  
Chloe E. James ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Antibiotic Treatment ◽  
Epidemic Strain ◽  
Phage Production

ABSTRACTPhage production in response to antibiotics varied among four isolates of aPseudomonasaeruginosacystic fibrosis (CF) epidemic strain. Whereas ciprofloxacin induced higher levels of phage production, other CF-relevant antibiotics led to reduced production. We detected free phages directly in CF patient sputum samples by both plaque (40% positive) and PCR (76% positive) assays. Our observations suggest that the choice of antibiotics could influence the number of free phages within the CF lung environment.

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