scholarly journals C-kit expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and monomorphic adenoma

2003 ◽  
Vol 95 (5) ◽  
pp. 586-593 ◽  
Author(s):  
Paul C. Edwards ◽  
Tawfigul Bhuiya ◽  
Robert D. Kelsch
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Gland Neoplasms ◽  
Low Grade ◽  
Adenoid Cystic ◽  
Monomorphic Adenoma

Estrogen receptor assay in polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma of salivary gland origin

1994 ◽  
Vol 77 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Arthur S. Miller ◽  
Grace G. Hartman ◽  
Sow-Yeh Chen ◽  
Pamela R. Edmonds ◽  
Signe A. Brightman ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Low Grade ◽  
Adenoid Cystic ◽  
Receptor Assay

Mixed Tumor, Polymorphous Low-grade Adenocarcinoma and Adenoid Cystic Carcinoma of the Salivary Gland

1997 ◽  
Vol 5 (1) ◽  
pp. 8-16 ◽  
Author(s):  
Hannah Vargas ◽  
Daniel Sudilovsky ◽  
Michael J. Kaplan ◽  
Joseph A. Regezi ◽  
Noel Weidner
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Low Grade ◽  
Mixed Tumor ◽  
Adenoid Cystic

scholarly journals TP53 mutations in salivary gland neoplasms

2005 ◽  
Vol 16 (2) ◽  
pp. 162-166 ◽  
Author(s):  
Luciana Fasanella Matizonkas-Antonio ◽  
Ricardo Alves de Mesquita ◽  
Suzana C. Orsini Machado de Souza ◽  
Fabio Daumas Nunes
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Tp53 Gene ◽  
Salivary Gland Neoplasms ◽  
Low Grade ◽  
Chain Reaction ◽  
Adenoid Cystic ◽  
Single Stranded Conformational Polymorphism ◽  
Mutation Profile ◽  
Polymerase Chain

Many studies have demonstrated that loss of TP53 gene function has an important role in the genesis of many neoplasms, including salivary gland neoplasms. The purpose of this study was to examine the mutation profile of the TP53 gene in salivary gland neoplasms. Genomic DNA was extracted from paraffin-embedded tissues of pleomorphic adenoma, carcinoma in pleomorphic adenoma, mucoepidermoid carcinoma, adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. Exons 5 to 8 of the TP53 gene were amplified by polymerase chain reaction (PCR) to perform single-stranded conformational polymorphism (SSCP) analysis. Band shifting was observed in exons 5, 6 and 8 in 9 out of 18 neoplasms. The results of this study suggest that mutations in TP53 gene are related to salivary gland neoplasms pathogenesis and that exons 5 and 8 are most frequently involved.

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