A retrospective investigation of advanced periodontal disease as a risk factor for septicemia in hematopoietic stem cell and bone marrow transplant recipients

2002 ◽  
Vol 94 (5) ◽  
pp. 581-588 ◽  
Author(s):  
Sunday O. Akintoye ◽  
Michael T. Brennan ◽  
Christopher J. Graber ◽  
Beth E. McKinney ◽  
Thomas E. Rams ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Risk Factor ◽  
Stem Cell ◽  
Periodontal Disease ◽  
Bone Marrow Transplant ◽  
Hematopoietic Stem Cell ◽  
Marrow Transplant ◽  
Transplant Recipients ◽  
Hematopoietic Stem ◽  
Retrospective Investigation

scholarly journals Noninvasive Tracking of Hematopoietic Stem Cells in a Bone Marrow Transplant Model

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 939
Author(s):  
Fernando A. Oliveira ◽  
Mariana P. Nucci ◽  
Igor S. Filgueiras ◽  
João M. Ferreira ◽  
Leopoldo P. Nucci ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Bone Marrow Transplant ◽  
Hematopoietic Stem Cell ◽  
Marrow Transplant ◽  
Hematopoietic Progenitor Cell ◽  
Emission Computed Tomography ◽  
Cell Renewal ◽  
Hematopoietic Stem ◽  
Transplant Model

The hematopoietic stem cell engraftment depends on adequate cell numbers, their homing, and the subsequent short and long-term engraftment of these cells in the niche. We performed a systematic review of the methods employed to track hematopoietic reconstitution using molecular imaging. We searched articles indexed, published prior to January 2020, in PubMed, Cochrane, and Scopus with the following keyword sequences: (Hematopoietic Stem Cell OR Hematopoietic Progenitor Cell) AND (Tracking OR Homing) AND (Transplantation). Of 2191 articles identified, only 21 articles were included in this review, after screening and eligibility assessment. The cell source was in the majority of bone marrow from mice (43%), followed by the umbilical cord from humans (33%). The labeling agent had the follow distribution between the selected studies: 14% nanoparticle, 29% radioisotope, 19% fluorophore, 19% luciferase, and 19% animal transgenic. The type of graft used in the studies was 57% allogeneic, 38% xenogeneic, and 5% autologous, being the HSC receptor: 57% mice, 9% rat, 19% fish, 5% for dog, porcine and salamander. The imaging technique used in the HSC tracking had the following distribution between studies: Positron emission tomography/single-photon emission computed tomography 29%, bioluminescence 33%, fluorescence 19%, magnetic resonance imaging 14%, and near-infrared fluorescence imaging 5%. The efficiency of the graft was evaluated in 61% of the selected studies, and before one month of implantation, the cell renewal was very low (less than 20%), but after three months, the efficiency was more than 50%, mainly in the allogeneic graft. In conclusion, our review showed an increase in using noninvasive imaging techniques in HSC tracking using the bone marrow transplant model. However, successful transplantation depends on the formation of engraftment, and the functionality of cells after the graft, aspects that are poorly explored and that have high relevance for clinical analysis.

scholarly journals Contamination of Bone Marrow Products with an Actinomycete ResemblingMicrobacteriumSpecies and Reinfusion into Autologous Stem Cell and Bone Marrow Transplant Recipients

2003 ◽  
Vol 36 (10) ◽  
pp. e115-e121 ◽  
Author(s):  
Zahir Hirji ◽  
Ronnie Saragosa ◽  
Heln Dedier ◽  
Michael Crump ◽  
Norman Franke ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Bone Marrow Transplant ◽  
Marrow Transplant ◽  
Transplant Recipients

Murine hematopoietic stem cell characterization and its regulation in BM transplantation

Blood ◽  
2000 ◽  
Vol 96 (9) ◽  
pp. 3016-3022 ◽  
Author(s):  
Yi Zhao ◽  
Yuanguang Lin ◽  
Yuxia Zhan ◽  
Gengjie Yang ◽  
Jeffrey Louie ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Sorting ◽  
Cell Subset ◽  
Transplant Recipients ◽  
Hematopoietic Stem ◽  
Murine Hematopoietic Stem Cell

Using 5-color fluorescence-activated cell sorting, we isolated a subset of murine pluripotent hematopoietic stem cells (PHSC) with the phenotype Lin− Sca+ kit+CD38+ CD34− that appears to fulfill the criteria for most primitive PHSC. In the presence of whole bone marrow (BM) competitor cells, these cells produced reconstitution in lethally irradiated primary, secondary, and tertiary murine transplant recipients over the long term. However, these cells alone could not produce reconstitution in lethally irradiated recipients. Rapid proliferation of these cells after BM transplantation required the assistance of another BM cell subset, which has the phenotype Lin− Sca+ kit+ CD38−CD34+.

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