The influence of antifungal drugs on virulence properties of Candida albicans in patients with diabetes mellitus

2001 ◽  
Vol 91 (3) ◽  
pp. 317-321 ◽  
Author(s):  
Amanda M. Willis ◽  
Wilson A. Coulter ◽  
Catherine R. Fulton ◽  
John R. Hayes ◽  
Patrick M. Bell ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Candida Albicans ◽  
Antifungal Drugs ◽  
Patients With Diabetes ◽  
Virulence Properties

scholarly journals Fungus ball and emphysematous cystitis secondary to Candida tropicalis: A case report

2015 ◽  
Vol 9 (9-10) ◽  
pp. 683 ◽  
Author(s):  
Lei Wang ◽  
Xiang Ji ◽  
Guo-feng Sun ◽  
Ying-chao Qin ◽  
Miao-zi Gong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Antifungal Therapy ◽  
Candida Tropicalis ◽  
Antifungal Drugs ◽  
Surgical Removal ◽  
Fungus Ball ◽  
Left Wall ◽  
Emphysematous Cystitis ◽  
Patients With Diabetes ◽  
Systemic Antifungal Therapy

Fungus ball and fungal emphysematous cystitis are two rare complications of fungal urinary tract infection. A 53-year-old male patient presented with these complications caused by Candida tropicalis simultaneously. The predisposing factors were diabetes mellitus and usage of broad-spectrum antibiotics. The fungus ball, measuring 3.5 × 2.0 cm on the left wall of the urinary bladder, shrank significantly to 1.6 × 0.8 cm after 5 days of intermittent irrigation with saline before surgery. With transurethral removal of the fungus ball and antifungal treatment with fluconazole, the patient fully recovered. We conclude that a bladder fungus ball and fungal emphysematous cystitis should always be suspected in patients with diabetes mellitus with uncontrolled funguria and abnormal imaging. Treatment should include a systemic antifungal therapy and thorough surgical removal of the fungus ball. A systemic antifungal therapy combined with a local irrigation with saline or antifungal drugs might help decrease the dissemination of fungemia during an invasive manipulation.

scholarly journals Evaluation of proteinase and phospholipase activity of Candida albicans strains isolated from the mouth of patients with controlled and uncontrolled diabetes mellitus in Qazvin province: Short Communication

2021 ◽  
pp. 402-407
Keyword(s):  
Diabetes Mellitus ◽  
Candida Albicans ◽  
Hydrolytic Enzymes ◽  
Diabetic Patients ◽  
Target Tissue ◽  
Phospholipase Activity ◽  
Host Cell Membrane ◽  
Uncontrolled Diabetes ◽  
Significant Difference ◽  
Patients With Diabetes

Pathophysiological changes in the mouth of patients with diabetes mellitus (DM) predispose to overgrowth of Candida albicans. Various virulence factors such as proteinase and phospholipase production are involved in the process of degradation of the host cell membrane. These enzymes are involved in binding Candida species, especially in the hyphae stage, to the target tissue. In this study, the proteinase and phospholipase activity of 51 C. albicans strains was evaluated. Overall, the rates of proteolytic and phospholipase activities in controlled and uncontrolled diabetic patients were 90.2% and 72.5%, respectively. No significant difference was observed between proteinase and phospholipase activities in both groups of patients (P>0.05), while there was a significant difference between the activity of hydrolytic enzymes with HbA1C and dentures in the uncontrolled diabetic group (P<0.05). According to the importance of hydrolytic enzymes activity of C. albicans species in diabetic patients, oral health of diabetic patients to control and prevent disease progression in these patients is essential.

scholarly journals GAMBARAN JAMUR Candida sp. DALAM URINE PENDERITA DIABETES MELLITUS DI RSUD dr. RASIDIN PADANG

2018 ◽  
Vol 5 (1) ◽  
pp. 46-50
Author(s):  
Sri Indrayati ◽  
Suraini Suraini ◽  
Melda Afriani
Keyword(s):  
Diabetes Mellitus ◽  
Candida Albicans ◽  
General Hospital ◽  
Vaginal Wall ◽  
The Body ◽  
Vaginal Mucosa ◽  
Candida Sp ◽  
Gram Staining ◽  
As Species ◽  
Patients With Diabetes

The women with Diabetes Mellitus have extra sugar in the vaginal wall, thus providing food for the growth of fungi such as Candida albicans. Candida is a normal and widely distributed flora in the body especially in the digestive tract mucous membranes (24%) and vaginal mucosa (5-11%). This fungus is opportunistic and some Candida species can cause infections such as Candida tropicalis, Candida glablata and Candida albicans as species that most often cause infection. The disease caused by this fungus is known as Candidiasis and often occurs in the oropharynx and vagina. One of the predisposing factors that can change the saprophytic nature of Candida sp. being a pathogen is Diabetes Mellitus. This study aims to determine the description of Candida sp. in the urine of Diabetes Mellitus patients at the Regional General Hospital Dr. Rasidin Padang in February-June 2018. This study uses descriptive methods. With a population of all urine patients with Diabetes Mellitus patients obtained a sample of 22 patients based on the criteria treated at the Regional General Hospital (RSUD) dr. Rasidin Padang in March-May 2018. Examination of specimens is done macroscopically using PDA media and microscopically with gram staining. The results showed that of the 22 urine samples examined, there were 3 positive samples containing Candida sp fungi with a percentage of 13.64%

Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

1985 ◽  
Vol 43 ◽  
pp. 682-683
Author(s):  
Bruce R. Pachter
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Nerves ◽  
Sudden Onset ◽  
Extraocular Muscles ◽  
Diabetic Patients ◽  
Oculomotor Palsy ◽  
Third Nerve Palsy ◽  
Patients With Diabetes ◽  
Intramuscular Nerve ◽  
Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

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