Postcolposcopy management strategies for women referred with low-grade squamous intraepithelial lesions or human papillomavirus DNA–positive atypical squamous cells of undetermined significance: A two-year prospective study

2003 ◽  
Vol 188 (6) ◽  
pp. 1401-1405 ◽  
Author(s):  
Richard Guido ◽  
Mark Schiffman ◽  
Diane Solomon ◽  
Louis Burke
Keyword(s):  
Human Papillomavirus ◽  
Prospective Study ◽  
Management Strategies ◽  
Low Grade ◽  
Squamous Intraepithelial Lesions ◽  
Squamous Cells ◽  
Intraepithelial Lesions ◽  
Papillomavirus Dna ◽  
Undetermined Significance

scholarly journals Colposcopy, cervical cytology and human papillomavirus detection as screening tools for cervical cancer

2001 ◽  
Vol 7 (1-2) ◽  
pp. 100-105
Author(s):  
Al Alwan Al Alwan
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Pap Test ◽  
Screening Tools ◽  
Low Grade ◽  
Squamous Intraepithelial Lesions ◽  
Sampling Device ◽  
Squamous Cells ◽  
The Bethesda System ◽  
Intraepithelial Lesions

A cohort of 77 women referred for routine screening or investigation of Pap test abnormality underwent colposcopic examination. Pap-stained liquid-based preparations were diagnosed and categorized according to the Bethesda system. Residual material on the sampling device was used to detect high-risk oncogenic human papillomavirus DNA. Although the colposcopic failure rate was higher than that of cytology, no lesion was missed when both methods were used together. High-risk types were recorded in 24% of patients with atypical squamous cells of undetermined significance, 45% with low-grade squamous intraepithelial lesions and 79% with high-grade squamous intraepithelial lesions-indicating that the efficacy of cytological screening can be improved by papillomavirus detection.

Whole-Slide Imaging of Pap Cellblock Preparations Is a Potentially Valid Screening Method

2015 ◽  
Vol 59 (2) ◽  
pp. 187-200 ◽  
Author(s):  
Ossama Tawfik ◽  
Marilyn Davis ◽  
Susan Dillon ◽  
Laila Tawfik ◽  
Francisco J. Diaz ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Low Grade ◽  
Adenocarcinoma In Situ ◽  
High Grade ◽  
Whole Slide Imaging ◽  
Squamous Intraepithelial Lesions ◽  
Squamous Cells ◽  
The Impact ◽  
Intraepithelial Lesions ◽  
Undetermined Significance

Objective: To date, the impact of digital imaging on routine cytology remains far from perfect. Cellblock (CB) preparations from Pap samples have been shown to be diagnostically valuable. We evaluated the validity of utilizing whole-slide imaging (WSI) prepared from Pap CBs as a screening tool. Study Design: A total of 1,110 CB slides prepared from residual Pap samples were analyzed - 563 normal, 282 atypical squamous cells of undetermined significance (ASCUS), 12 atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion, 188 low-grade squamous intraepithelial lesions (LSIL), 36 high-grade squamous intraepithelial lesions (HSIL), 25 atypical glandular cells of undetermined significance, 1 adenocarcinoma in situ, 2 invasive adenocarcinomas, and 1 squamous cell carcinoma. Virtual slides were obtained using the Aperio system. Test performance characteristics of liquid-based samples and WSI from CB samples were compared. Results: Average sensitivity and specificity of the five WSI reviewers was 58.3 and 85.1% for ASCUS, respectively, 54.1 and 93.9% for LSIL, and 51.8 and 98.8% for HSIL. Overall WSI sensitivity and specificity for detecting lesions was 82.1 and 86.2%, respectively. Agreement (kappa values) between WSI reviewers was 0.56 for ASCUS, 0.69 for LSIL, 0.67 for HSIL, and 0.74 for negative samples. Conclusions: WSI of CB preparations is a feasible method to achieve high-quality specimen preparations. It is as sensitive as liquid-based methods and appears to be highly specific for the detection of LSIL and HSIL.

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