Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse

2002 ◽  
Vol 187 (1) ◽  
pp. 56-63 ◽  
Author(s):  
Muriel K. Boreham ◽  
Clifford Y. Wai ◽  
Rodney T. Miller ◽  
Joseph I. Schaffer ◽  
R.Ann Word
Keyword(s):  
Smooth Muscle ◽  
Pelvic Organ Prolapse ◽  
Morphometric Analysis ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall

scholarly journals Changes in muscularis propria of anterior vaginal wall in women with pelvic organ prolapse

2016 ◽  
Vol 60 (1) ◽  
Author(s):  
A. Vetuschi ◽  
A. D'Alfonso ◽  
R. Sferra ◽  
D. Zanelli ◽  
S. Pompili ◽  
...  
Keyword(s):  
Risk Factors ◽  
Smooth Muscle ◽  
Pelvic Organ Prolapse ◽  
Smooth Muscle Cells ◽  
Muscularis Propria ◽  
Muscle Cells ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall ◽  
Collagen Iii

<p>The objective<strong> </strong>of this study was to evaluate the morphological and immunohistochemical alterations of tissue removed from the upper third of anterior vaginal wall in a sample group of the female population presenting homogenous risk factors associated with Pelvic Organ Prolapse (POP). The case study consisted of 14 patients with POP and there were 10 patients in the control group. Patient selection was carried on the basis of specific criteria and all of the patients involved in the study presented one or more of the recognized POP risk factors. Samples were taken from POP patients during vaginal plastic surgery following  colpohysterectomy, and from control patients during closure of the posterior fornix following hysterectomy. Samples were processed for histological and  immunohistochemical analyses for Collagen I and Collagen III, α-Smooth Muscle Actin (α-SMA), Platelet-Derived-Growth-Factor (PDGF), matrix metalloproteinase 3 (MMP3), Caspase3. Immunofluorescence analyses for Collagen I and III and PDGF were also carried out. In prolapsed specimens our results show a disorganization of smooth muscle cells that appeared to have been displaced by an increased collagen III deposition resulting in rearrangement of the muscularis propria architecture. These findings suggest that the increase in the expression of collagen fibers in muscularis could probably due to a phenotypic switch resulting in the dedifferentiation of smooth muscle cells into myofibroblasts. These alterations could be responsible for the compromising of the dynamic functionality of the pelvic floor.</p><p><strong> </strong></p>

Comparative histological analysis of anterior vaginal wall in women with pelvic organ prolapse or control subjects. A pilot study

2008 ◽  
Vol 19 (5) ◽  
pp. 723-729 ◽  
Author(s):  
Wassim Badiou ◽  
Guillaume Granier ◽  
Philippe-Jean Bousquet ◽  
Xavier Monrozies ◽  
Pierre Mares ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Pilot Study ◽  
Histological Analysis ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall ◽  
Control Subjects

Smooth muscle fraction of the round ligament in women with pelvic organ prolapse: a computer-based morphometric analysis

2004 ◽  
Vol 16 (1) ◽  
pp. 39-43 ◽  
Author(s):  
Ozlem Ozdegirmenci ◽  
Yildirim Karslioglu ◽  
Suat Dede ◽  
Sinan Karadeniz ◽  
Ali Haberal ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Pelvic Organ Prolapse ◽  
Morphometric Analysis ◽  
Pelvic Organ ◽  
Round Ligament ◽  
Computer Based

scholarly journals Neurovascular alterations of muscularis propria in the human anterior vaginal wall in pelvic organ prolapse

2019 ◽  
Vol 235 (2) ◽  
pp. 281-288 ◽  
Author(s):  
R Sferra ◽  
S Pompili ◽  
A D'Alfonso ◽  
G Sabetta ◽  
E Gaudio ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Muscularis Propria ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall

scholarly journals Tenascin-C is Strongly Expressed in the Anterior Vaginal Walls of Women with Pelvic Organ Prolapse

2016 ◽  
Author(s):  
Risma N. Sulham
Keyword(s):  
Body Mass Index ◽  
Pelvic Organ Prolapse ◽  
Body Mass ◽  
Menopausal Status ◽  
Pelvic Organ ◽  
Cross Sectional Study ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall ◽  
Cross Sectional ◽  
Significance Level

Objectives: To compare the expression of tenascin in the anterior vaginal wall in women with pelvic organ prolapse and without pelvic organ prolapse (POP). Method: This study was a cross sectional study. The study was conducted in RS Dr. Wahidin Sudirohusodo and other network hospitals of Obstetrics and Gynecology Department of Hasanuddin University, Makassar, from 1st January 2011 to 1st April 2012. This study assessed the expression of tenascin in 35 women with pelvic organ prolapse grade III and IV and the controls were 35 women without pelvic organ prolapse. Tenascin expression was assessed by immunohistochemical examination using tenascin antibody staining (mouse monoclonal antibody Novacastratenascin C, code NCLTenasC). Sampling was done by consecutive sampling. Data processed by the chi-square. The significance level used was 0.05. Result: The result of this research shows that with exception of history of bearing baby > 4000 gr weight (p=0.572); age, parity, menopausal status, and body mass index were significantly different between the group. This indicates that the variable does not affect the calculation of research data. While parity, menopausal status and body mass index (BMI), from an analysis of risk factors for POP were associated with increased intensity of tenascin is significant in postmenopausal status, and BMI > 25 (overweight) (p

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