Effects of maternal betamethasone administration on fetal and maternal blood pressure and heart rate in the baboon at 0.7 of gestation

2002 ◽  
Vol 186 (4) ◽  
pp. 812-817 ◽  
Author(s):  
S.V. Koenen ◽  
C.A. Mecenas ◽  
G.S. Smith ◽  
S. Jenkins ◽  
P.W. Nathanielsz
1990 ◽  
Vol 18 (s1) ◽  
pp. 25-25
Author(s):  
K.J. Dalton ◽  
P. Mooney ◽  
W. Cartwright ◽  
H. Swindells ◽  
S. Rushant

2002 ◽  
Vol 96 (5) ◽  
pp. 1123-1128 ◽  
Author(s):  
Linda S. Polley ◽  
Malachy O. Columb ◽  
Norah N. Naughton ◽  
Deborah S. Wagner ◽  
Cosmas J. M. van de Ven

Background The minimum local analgesic concentration (MLAC) has been defined as the median effective local analgesic concentration in a 20-ml volume for epidural analgesia in the first stage of labor. The aim of this study was to determine the local anesthetic-sparing efficacy of epidural epinephrine by its effect on the MLAC of bupivacaine. Methods In this double-blind, randomized, prospective study, 70 parturients who were at 7 cm or less cervical dilation and who requested epidural analgesia were allocated to one of two groups. After lumbar epidural catheter placement, 20 ml bupivacaine (n = 35) or bupivacaine with epinephrine 1:300,000 (n = 35) was administered. The concentration of bupivacaine was determined by the response of the previous patient in that group to a higher or lower concentration using up-down sequential allocation. Analgesic efficacy was assessed using 100-mm visual analog pain scores, with 10 mm or less within 30 min defined as effective. Results The MLAC of bupivacaine alone was 0.091% wt/vol (95% confidence interval, 0.081-0.102). The addition of epinephrine 1:300,000 (66.7 microg) resulted in a significant reduction (P < 0.01) in the MLAC of bupivacaine to 0.065% wt/vol (95% confidence interval, 0.047-0.083). The lowest maternal blood pressure was significantly lower in the bupivacaine-epinephrine group (P = 0.03). There were statistically significant reductions in fetal heart rate (P = 0.011) in the bupivacaine-epinephrine group that were not clinically significant. Conclusions The addition of epidural epinephrine 1:300,000 (66 microg) resulted in a significant 29% reduction in the MLAC of bupivacaine. Coincident reductions in fetal heart rate and maternal blood pressure were also observed that were not clinically significant.


2014 ◽  
Vol 93 (7) ◽  
pp. 678-683 ◽  
Author(s):  
Cristine H. Ferreira ◽  
Luciane M.V. Naldoni ◽  
Juliana dos Santos Ribeiro ◽  
Maria Cristina C.C. Meirelles ◽  
Ricardo de Carvalho Cavalli ◽  
...  

Author(s):  
Tsegaselassie Workalemahu ◽  
Mohammad L. Rahman ◽  
Marion Ouidir ◽  
Jing Wu ◽  
Cuilin Zhang ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document