Age effects on urethral striated muscle II. Anatomic location of muscle loss

2002 ◽  
Vol 186 (3) ◽  
pp. 356-360 ◽  
Author(s):  
Daniele Perucchini ◽  
John O.L. DeLancey ◽  
James A. Ashton-Miller ◽  
Andrzej Galecki ◽  
Gabriel N. Schaer
Keyword(s):  
Striated Muscle ◽  
Age Effects ◽  
Muscle Loss ◽  
Anatomic Location ◽  
Urethral Striated Muscle

Age effects on urethral striated muscle I. changes in number and diameter of striated muscle fibers in the ventral urethra

2002 ◽  
Vol 186 (3) ◽  
pp. 351-355 ◽  
Author(s):  
Daniele Perucchini ◽  
John OL. DeLancey ◽  
James A. Ashton-Miller ◽  
Ursula Peschers ◽  
Tripti Kataria
Keyword(s):  
Striated Muscle ◽  
Muscle Fibers ◽  
Age Effects ◽  
Striated Muscle Fibers ◽  
Urethral Striated Muscle

scholarly journals Morphological changes in the fast vs slow fiber profiles of the urethras of diabetic pregnant rats

2011 ◽  
Vol 25 (1) ◽  
pp. 9 ◽  
Author(s):  
Gabriela Marini ◽  
Angélica M. Pascon Barbosa ◽  
Débora C. Damasceno ◽  
Selma M. Michelin Matheus ◽  
Rodrigo De Aquino Castro ◽  
...  
Keyword(s):  
Striated Muscle ◽  
Morphological Changes ◽  
Fiber Type ◽  
Normal Function ◽  
Striated Muscles ◽  
Pregnant Rats ◽  
Morphological Alterations ◽  
Female Wistar Rats ◽  
Urethral Striated Muscle ◽  
Diabetes And Pregnancy

<em>Background</em>. This study was undertaken to test the hypothesis that diabetes and pregnancy detrimentally affect the normal function of urethral striated muscles in rats, providing a model for additional studies related to urinary incontinence. The aim of this study was to evaluate morphological alterations in the urethral striated muscles of diabetic pregnant rats. <em>Design and methods. </em>Twenty female Wistar rats were distributed into four experimental groups of five rats as follows: virgin, pregnant, diabetic virgin, and diabetic pregnant. Diabetes was induced using streptozotocin administration (40 mg/kg i.v.). The rats were lethally anesthetized, and the urethra and vagina were extracted as a unit. Cryostat sections (6 µm thick) were cut and stained with hematoxylin-eosin, and immunohistochemical procedures were performed and subjected to morphological and semi quantitative analysis. <em>Results</em>. The urethral striated muscle from the diabetic pregnant rats presented with the following variations: thinning and atrophy, disorganization and disruption associated with the colocalization of fast and slow fibers and a steady decrease in the proportion of fast <em>vs</em> slow fibers. <em>Conclusion</em>. Diabetes and pregnancy impair the urethral striated muscle and alter its fiber type distribution.

scholarly journals Duloxetine in the Treatment of Stress Urinary Incontinence

2005 ◽  
Vol 1 (3) ◽  
pp. 345-358 ◽  
Author(s):  
Martin C Michel ◽  
Matthias Oelke
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Adverse Events ◽  
Striated Muscle ◽  
Bladder Capacity ◽  
Efficacy And Safety ◽  
Cytochrome P450 1A2 ◽  
Serious Adverse Events ◽  
Double Blind ◽  
Urethral Striated Muscle

This manuscript reviews the pharmacodynamics and pharmacokinetics of duloxetine and its efficacy and safety in women with stress urinary incontinence. Duloxetine is a selective inhibitor of neuronal serotonin and norepinephrine uptake which increases urethral striated muscle activity and bladder capacity. Duloxetine is readily absorbed and extensively metabolized; cytochrome P450 1A2 (CYP1A2) inhibiting drugs can markedly increase duloxetine exposure. The clinical efficacy of duloxetine has consistently been demonstrated in several randomized, double-blind studies in women with moderate-to-severe stress urinary incontinence, but the additional benefit relative to placebo was moderate. Duloxetine treatment is frequently associated with adverse events such as nausea, dry mouth, fatigue, insomnia and constipation, but serious adverse events are rare. Therefore, duloxetine appears suitable for the treatment of stress urinary incontinence.

scholarly journals Conduction block of mammalian myelinated nerve by local cooling to 15–30°C after a brief heating

2016 ◽  
Vol 115 (3) ◽  
pp. 1436-1445 ◽  
Author(s):  
Zhaocun Zhang ◽  
Timothy D. Lyon ◽  
Brian T. Kadow ◽  
Bing Shen ◽  
Jicheng Wang ◽  
...  
Keyword(s):  
Striated Muscle ◽  
Conduction Block ◽  
Local Cooling ◽  
Myelinated Nerve ◽  
Axonal Conduction ◽  
Novel Method ◽  
Myelinated Nerves ◽  
Block Temperature ◽  
Scientific Questions ◽  
Urethral Striated Muscle

This study aimed at understanding thermal effects on nerve conduction and developing new methods to produce a reversible thermal block of axonal conduction in mammalian myelinated nerves. In 13 cats under α-chloralose anesthesia, conduction block of pudendal nerves ( n = 20) by cooling (5–30°C) or heating (42–54°C) a small segment (9 mm) of the nerve was monitored by the urethral striated muscle contractions and increases in intraurethral pressure induced by intermittent (5 s on and 20 s off) electrical stimulation (50 Hz, 0.2 ms) of the nerve. Cold block was observed at 5–15°C while heat block occurred at 50–54°C. A complete cold block up to 10 min was fully reversible, but a complete heat block was only reversible when the heating duration was less than 1.3 ± 0.1 min. A brief (<1 min) reversible complete heat block at 50–54°C or 15 min of nonblock mild heating at 46–48°C significantly increased the cold block temperature to 15–30°C. The effect of heating on cold block fully reversed within ∼40 min. This study discovered a novel method to block mammalian myelinated nerves at 15–30°C, providing the possibility to develop an implantable device to block axonal conduction and treat many chronic disorders. The effect of heating on cold block is of considerable interest because it raises many basic scientific questions that may help reveal the mechanisms underlying cold or heat block of axonal conduction.

scholarly journals Regenerating Urethral Striated Muscle by CRISPRi/dCas9-KRAB-Mediated Myostatin Silencing for Obesity-Associated Stress Urinary Incontinence

2020 ◽  
Vol 3 (6) ◽  
pp. 562-572
Author(s):  
Huixing Yuan ◽  
Yajun Ruan ◽  
Yan Tan ◽  
Amanda B. Reed-Maldonado ◽  
Yinwei Chen ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Striated Muscle ◽  
Urethral Striated Muscle

scholarly journals Microenergy acoustic pulses induced myogenesis of urethral striated muscle stem/progenitor cells

2019 ◽  
Vol 8 (5) ◽  
pp. 489-500 ◽  
Author(s):  
Kai Cui ◽  
Ning Kang ◽  
Lia Banie ◽  
Tie Zhou ◽  
Tianshu Liu ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Striated Muscle ◽  
Urethral Striated Muscle
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