Low-dose folic acid supplementation reduces plasma levels of the cardiovascular risk factor homocysteine in postmenopausal women

2000 ◽  
Vol 183 (4) ◽  
pp. 945-947 ◽  
Author(s):  
Vincenzo De Leo ◽  
Antonio la Marca ◽  
Giuseppe Morgante ◽  
Federica Ciani ◽  
Enrico Zammarchi ◽  
...  
Keyword(s):  
Risk Factor ◽  
Folic Acid ◽  
Cardiovascular Risk ◽  
Postmenopausal Women ◽  
Cardiovascular Risk Factor ◽  
Plasma Levels ◽  
Low Dose ◽  
Folic Acid Supplementation ◽  
Acid Supplementation

Low-dose folic acid supplementation reduces homocysteine concentration in hyperhomocysteinemic coronary artery disease patients

2006 ◽  
Vol 26 (9) ◽  
pp. 460-466 ◽  
Author(s):  
Ping-Ting Lin ◽  
Bor-Jen Lee ◽  
Han-Hsin Chang ◽  
Chien-Hsiang Cheng ◽  
An-Jung Tsai ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Folic Acid ◽  
Coronary Artery ◽  
Low Dose ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Homocysteine Concentration ◽  
Artery Disease

scholarly journals l-Folic Acid Supplementation in Healthy Postmenopausal Women: Effect on Homocysteine and Glycolipid Metabolism

2005 ◽  
Vol 90 (8) ◽  
pp. 4622-4629 ◽  
Author(s):  
Paola Villa ◽  
Concetta Perri ◽  
Rosanna Suriano ◽  
Francesco Cucinelli ◽  
Simona Panunzi ◽  
...  
Keyword(s):  
Folic Acid ◽  
Postmenopausal Women ◽  
Area Under The Curve ◽  
Density Lipoprotein ◽  
Folic Acid Supplementation ◽  
Oral Glucose ◽  
Loading Test ◽  
Acid Supplementation ◽  
Hepatic Insulin Extraction ◽  
Methionine Loading Test

Context: Hyperhomocysteinemia as well as alterations of glycemic and lipidic metabolism are recognized as risk factors for cardiovascular diseases. Objective: The aim of this study was to examine the effect of l-folic acid supplementation on homocysteine (Hcy) and related thiols, such as cysteine (Cys) and Cys-glycine (Cys-Glyc) pathways and their relationship to glucose, insulin, and lipidic metabolism in normoinsulinemic postmenopausal women. Design: This study was a randomized placebo, not double-blind, trial. Setting: The study was performed in an academic research center. Patients or Other Participants: Twenty healthy postmenopausal women were selected. No patient was taking drugs known to affect lipid or glucose metabolism. Intervention(s): Patients underwent two hospitalizations before and after 8 wk of l-acid folic (7.5 mg/d) or placebo administration. The glycemic metabolism was studied by an oral glucose tolerance test and a hyperinsulinemic euglycemic clamp. Hcy metabolism was studied by a standardized oral methionine-loading test. Main Outcome Measure(s): Hcy, Cys, and Cys-Glyc, basally and after a methionine loading test, were measured. Basal insulin, glucose, and peptide C levels as well as area under the curve for insulin, area under the curve for peptide, hepatic insulin extraction, and metabolic index were assayed. The total cholesterol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol levels and the cholesterol/HDL and LDL/HDL ratios were also measured. Results: The total basal Hcy concentration and the plasma postmethionine loading Hcy values were significantly decreased (P < 0.01) in l-folic acid-treated patients, whereas postmethionine loading Cys-Glyc levels were markedly increased (P < 0.02). Furthermore, l-folic acid intake induced a significant improvement in carbohydrate metabolism through an increase in fractional hepatic insulin extraction (P < 0.05) and peripheral insulin sensitivity (P < 0.02) in normoinsulinemic women. HDL levels considerably increased, inducing an improvement in other atherosclerotic indexes, such as cholesterol/HDL and LDL/HDL ratios (P < 0.03). Conclusions: These results show that folic acid supplementation lowers plasma Hcy levels and improves insulin and lipid metabolism, reducing the risk of cardiovascular disease.

Folic acid supplementation reduces plasma homocysteine in postmenopausal women

2016 ◽  
Vol 36 (4) ◽  
pp. 492-495 ◽  
Author(s):  
Fariba Almassinokiani ◽  
Maryam Kashanian ◽  
Peyman Akbari ◽  
Elaheh Mossayebi ◽  
Elena Sadeghian
Keyword(s):  
Folic Acid ◽  
Postmenopausal Women ◽  
Folic Acid Supplementation ◽  
Plasma Homocysteine ◽  
Acid Supplementation

scholarly journals The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis

1990 ◽  
Vol 33 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Sarah L. Morgan ◽  
Joseph E. Baggott ◽  
William H. Vaughn ◽  
Peggy K. Young ◽  
Janet V. Austin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Folic Acid ◽  
Low Dose ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Dose Methotrexate

scholarly journals Effect of long-term low-dose folic acid supplementation on degree of total homocysteine-lowering: major effect modifiers

2018 ◽  
Vol 120 (10) ◽  
pp. 1122-1130 ◽  
Author(s):  
Binyan Wang ◽  
Hongxu Wu ◽  
Youbao Li ◽  
Qianyun Ban ◽  
Xiao Huang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Low Dose ◽  
Methylenetetrahydrofolate Reductase ◽  
Smoking Status ◽  
Folic Acid Supplementation ◽  
Major Effect ◽  
Acid Supplementation ◽  
Total Homocysteine ◽  
Using Data

AbstractWe sought to examine the potential modifiers in the association between long-term low-dose folic acid supplementation and the reduction of serum total homocysteine (tHcy) among hypertensive patients, using data from the China Stroke Primary Prevention Trial (CSPPT). This analysis included 16 867 participants who had complete data on tHcy measurements at both the baseline and exit visit. After a median treatment period of 4·5 years, folic acid treatment significantly reduced the tHcy levels by 1·6 μmol/l (95 % CI 1·4, 1·8). More importantly, after adjustment for baseline tHcy and other important covariates, a greater degree of tHcy reduction was observed in certain subgroups: males, the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype, higher baseline tHcy levels (≥12·5 (median) v. <12·5 μmol/l), lower folate levels (<8·0 (median) v. ≥8·0 ng/ml), estimated glomerular filtration rate (eGFR) <60 ml/min per 1·73 m2 (v. 60–<90 and ≥90 ml/min per 1·73 m2), ever smokers and concomitant use of diuretics (P for all interactions <0·05). The degree of tHcy reduction associated with long-term folic acid supplementation can be significantly affected by sex, MTHFR C677T genotypes, baseline folate, tHcy, eGFR levels and smoking status.

Sign in / Sign up

Export Citation Format

Share Document