Large animal models of congestive heart failure: A critical step in translating basic observations into clinical applications

2003 ◽  
Vol 10 (1) ◽  
pp. 77-86 ◽  
Author(s):  
W Yarbrough
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Animal Models ◽  
Clinical Applications ◽  
Large Animal ◽  
Critical Step ◽  
Large Animal Models

Echocardiography Evaluation of a Novel Stable Ovine Heart Failure Model Suitable for Cardiovascular Device Testing

2011 ◽  
Author(s):  
Peter W. Walsh ◽  
Craig S. McLachlan ◽  
Leigh Ladd ◽  
Arie Blitz ◽  
R. Mark Gillies ◽  
...  
Keyword(s):  
Heart Failure ◽  
Animal Models ◽  
Large Animal ◽  
Failure Model ◽  
Large Animal Models ◽  
Surgical Model ◽  
Coronary Ligation ◽  
Rapid Ventricular Pacing ◽  
Heart Failure Model ◽  
Underlying Pathology

Numerous large animal models of chronic cardiac ischemia have been developed to explore either pathological mechanisms and or device interventions in developed heart failure models. Traditionally chronic heart failure in large animal models such as sheep or pigs has been induced by either coronary ligation with or without reperfusion. Coronary ligation is often attempted in the open chest surgical model or more recently in the closed chest animal via angiography [1]. Both techniques can be challenging and also induce high mortality with the risk of myocardial stunning and resultant shock and or lethal arrhythmias. There is also difficulty in developing stable heart failure across cases where infarct sizes can be variable. One strategy to over come this variability has been via rapid ventricular pacing, however inducing heart failure does not induce sustained heart failure in many cases if the pacing is switched off, and additionally pacing does not induce some of the underlying pathology seen in the development of heart failure [1].

scholarly journals Large Animal Models of Heart Failure

2009 ◽  
Vol 2 (3) ◽  
pp. 262-271 ◽  
Author(s):  
Jennifer A. Dixon ◽  
Francis G. Spinale
Keyword(s):  
Heart Failure ◽  
Animal Models ◽  
Large Animal ◽  
Large Animal Models

scholarly journals Therapeutic Resevoirs: Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models (Adv. Healthcare Mater. 11/2020)

2020 ◽  
Vol 9 (11) ◽  
pp. 2070035
Author(s):  
Garry P. Duffy ◽  
Scott T. Robinson ◽  
Raymond O'Connor ◽  
Robert Wylie ◽  
Ciaran Mauerhofer ◽  
...  
Keyword(s):  
Animal Models ◽  
Clinical Applications ◽  
Large Animal ◽  
Large Animal Models ◽  
Reservoir Systems

scholarly journals Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models

2020 ◽  
Vol 9 (11) ◽  
pp. 2000305 ◽  
Author(s):  
Garry P. Duffy ◽  
Scott T. Robinson ◽  
Raymond O'Connor ◽  
Robert Wylie ◽  
Ciaran Mauerhofer ◽  
...  
Keyword(s):  
Animal Models ◽  
Clinical Applications ◽  
Large Animal ◽  
Large Animal Models ◽  
Reservoir Systems
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