Carvedilol improves left ventricular function in heart failure patients with idiopathic dilated cardiomyopathy and a wide range of sympathetic nervous system function as measured by iodine 123 metaiodobenzylguanidine

2002 ◽  
Vol 9 (6) ◽  
pp. 608-615 ◽  
Author(s):  
M Gerson
Keyword(s):  
Heart Failure ◽  
Left Ventricular ◽  
Idiopathic Dilated Cardiomyopathy ◽  
System Function ◽  
Heart Failure Patients ◽  
Iodine 123 Metaiodobenzylguanidine ◽  
Wide Range ◽  
Nervous System Function ◽  
Iodine 123 ◽  
Sympathetic Nervous

scholarly journals Cardiac iodine-123-Metaiodobenzylguanidine imaging predicts cardiac events in heart failure patients evaluated for implantable cardiac defibrillator

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P261-P261
Author(s):  
P. Garcia-Gonzalez ◽  
O. Fabregat-Andres ◽  
P. Cozar-Santiago ◽  
J. Estornell-Erill ◽  
M. Ferrando-Beltran ◽  
...  
Keyword(s):  
Heart Failure ◽  
Implantable Cardiac Defibrillator ◽  
Cardiac Events ◽  
Heart Failure Patients ◽  
Iodine 123 Metaiodobenzylguanidine ◽  
Iodine 123

A Novel Noninvasive Device to Assess Sympathetic Nervous System Function in Patients With Heart Failure

2015 ◽  
Vol 64 (5) ◽  
pp. 351-360 ◽  
Author(s):  
Monica Parry ◽  
Chantelle A. Nielson ◽  
Fiona Muckle ◽  
Sheila O’Keefe-McCarthy ◽  
Rene van Lien ◽  
...  
Keyword(s):  
Heart Failure ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
System Function ◽  
Patients With Heart Failure ◽  
Nervous System Function ◽  
Sympathetic Nervous

Abstract 17860: Cardiac Iodine-123 Metaiodobenzylguanidine Imaging Predicts Poor Prognosis Even in Patients Admitted With Acute Decompensated Heart Failure

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Shunsuke Tamaki ◽  
Takahisa Yamada ◽  
Takashi Morita ◽  
Yoshio Furukawa ◽  
Yusuke Iwasaki ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Decompensated Heart Failure ◽  
Decompensated Heart Failure ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Washout Rate ◽  
Mibg Imaging ◽  
Ventricular Ejection Fraction ◽  
Iodine 123 Metaiodobenzylguanidine ◽  
Iodine 123

Introduction: Cardiac iodine-123 metaiodobenzylguanidine (MIBG) imaging has been shown to provide prognostic information in patients with chronic heart failure. However, little is known about the prognostic value of cardiac MIBG imaging in patients admitted with acute decompensated heart failure (ADHF). Hypothesis: We assessed the hypothesis that cardiac MIBG imaging might also be useful for the prediction of poor clinical outcome in patients admitted with ADHF. Methods: We studied 115 consecutive patients admitted for ADHF from October 2011 to January 2013 and discharged with survival (age: 74±13 years, male: 56%, NYHA class at discharge: 2.2±0.8, left ventricular ejection fraction measured by echocardiography: 47.1±15.5%). Cardiac MIBG imaging, echocardiography and venous blood sampling were performed just before discharge. The cardiac MIBG heart-to-mediastinum ratio (H/M) and washout rate were calculated from the chest anterior view images obtained at 20 and 200min after isotope injection. The endpoints were unplanned hospitalization for worsening heart failure (WHF) and pump failure death (PFD). Results: During a follow-up period of 2.0±0.8 years, 32 patients had WHF and 15 patients had PFD. At multivariate Cox analysis, out of the variables including clinical, hemodynamic, biochemical, echocardiographic and MIBG parameters, H/M on delayed image (late H/M) was independently associated with WHF (p=0.0003) and PFD (p=0.0255), although brain natriuretic peptide showed the significant association with the endpoints at univariate analysis. Kaplan-Meier analysis showed that the patients with late H/M <1.65 (mean value) had a significantly higher risk of both WHF and PFD than those with late H/M ≧1.65 (Figure). Conclusions: Cardiac MIBG imaging could predict poor outcome even in patients admitted with ADHF.

Sign in / Sign up

Export Citation Format

Share Document