Chronic hibernation and chronic stunning: A continuum

2000 ◽  
Vol 7 (5) ◽  
pp. 509-527 ◽  
Author(s):  
J CANTYJR ◽  
J FALLAVOLLITA
Keyword(s):  
Chronic Hibernation

Hibernating Myocardium

1998 ◽  
Vol 78 (4) ◽  
pp. 1055-1085 ◽  
Author(s):  
GERD HEUSCH
Keyword(s):  
Blood Flow ◽  
Myocardial Ischemia ◽  
Contractile Function ◽  
Myocardial Dysfunction ◽  
Experimental Studies ◽  
Reperfusion Therapy ◽  
Myocardial Contraction ◽  
Hibernating Myocardium ◽  
Short Term ◽  
Chronic Hibernation

Heusch, Gerd. Hibernating Myocardium. Physiol. Rev. 78: 1055–1085, 1998. — Decreased myocardial contraction occurs as a consequence of a reduction in blood flow. The concept of hibernation implies a downregulation of contractile function as an adaptation to a reduction in myocardial blood flow that serves to maintain myocardial integrity and viability during persistent ischemia. Unequivocal evidence for this concept exists in scenarios of myocardial ischemia that lasts for several hours, and sustained perfusion-contraction matching, recovery of energy and substrate metabolism, the potential for recruitment of inotropic reserve at the expense of metabolic recovery, and lack of necrosis are established criteria of short-term hibernation. The mechanisms of short-term hibernation, apart from reduced calcium responsiveness, are not clear at present. Experimental studies with chronic coronary stenosis lasting more than several hours have failed to continuously monitor flow and function. Nevertheless, a number of studies in chronic animal models and patients have demonstrated regional myocardial dysfunction at reduced resting blood flow that recovered upon reperfusion, consistent with chronic hibernation. Further studies are required to distinguish chronic hibernation from cumulative stunning. With a better understanding of the mechanisms underlying short-term hibernation, it is hoped that these adaptive responses can be recruited and reinforced to minimize the consequences of acute myocardial ischemia and delay impending infarction. Patients with chronic hibernation must be identified and undergo adequate reperfusion therapy.

Structural correlates of regional myocardial dysfunction in patients with critical coronary artery stenosis: Chronic hibernation?

1993 ◽  
Vol 2 (4) ◽  
pp. 237-245 ◽  
Author(s):  
Marcel Borgers ◽  
Fred Thoné ◽  
Luc Wouters ◽  
Jannie Ausma ◽  
Bharati Shivalkar ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Stenosis ◽  
Myocardial Dysfunction ◽  
Artery Stenosis ◽  
Chronic Hibernation

Effect of repetitive stunning on myocardial metabolism in pig hearts

1997 ◽  
Vol 273 (3) ◽  
pp. H1395-H1402 ◽  
Author(s):  
T. A. Hacker ◽  
B. Renstrom ◽  
S. H. Nellis ◽  
A. J. Liedtke
Keyword(s):  
Animal Studies ◽  
Glucose Utilization ◽  
Initial Conditions ◽  
Acid Oxidation ◽  
Mechanical Function ◽  
Short Term ◽  
Progressive Decline ◽  
Myocardial O2 Consumption ◽  
Animal Preparation ◽  
Chronic Hibernation

Recent animal and clinical studies have suggested that chronic hibernation, a condition of depressed mechanical function and enhanced glycolysis in viable but downregulated myocardium, may result from chronic repetitive ischemia and reperfusion. The present study was conducted to test whether similar trends could be reproduced in an acute animal preparation of repetitive stunning. Eight intact pig hearts were extracorporeally perfused for 115 min and subjected to four cycles of ischemia [60% decrease in anterior descending flow for 5 min each, interspersed with 15 min of aerobic reperfusion]. Each bout of ischemia caused a progressive decline in regional systolic shortening such that systolic shortening was 37% lower at end-reperfusion (P < 0.05 vs. initial conditions). Regional myocardial O2 consumption was reduced during ischemia but was not significantly lower at end-reperfusion compared with that under initial conditions. Fatty acid oxidation was unchanged at any point during the trials. Although glucose utilization was increased by an average of 264% during the four ischemic periods, it was not significantly or progressively increased during the reperfusion periods. Therefore, although this acute stunning protocol depressed mechanical function, it did not cumulatively increase glycolysis during reperfusion. This absence of accelerated glycolysis is at variance with the metabolic findings reported in clinical hibernation and raises concerns regarding this protocol in animal studies designed to simulate short-term hibernation.

scholarly journals Downregulation of Immunodetectable Connexin43 and Decreased Gap Junction Size in the Pathogenesis of Chronic Hibernation in the Human Left Ventricle

Circulation ◽  
1998 ◽  
Vol 97 (7) ◽  
pp. 651-660 ◽  
Author(s):  
Raffi R. Kaprielian ◽  
Mark Gunning ◽  
Emmanuel Dupont ◽  
Mary N. Sheppard ◽  
Stephen M. Rothery ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Gap Junction ◽  
Human Left Ventricle ◽  
Chronic Hibernation
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