An open pilot study using tacrolimus ointment in the treatment of seborrheic dermatitis

2003 ◽  
Vol 49 (1) ◽  
pp. 145-147 ◽  
Author(s):  
Azin Meshkinpour ◽  
Joannie Sun ◽  
Gerald Weinstein
Keyword(s):  
Pilot Study ◽  
Seborrheic Dermatitis ◽  
Tacrolimus Ointment ◽  
Open Pilot

Short-Term Ultramicronized Palmitoylethanolamide Therapy in Patients with Myasthenia Gravis: a Pilot Study to Possible Future Implications of Treatment

2019 ◽  
Vol 18 (3) ◽  
pp. 232-238 ◽  
Author(s):  
Emanuela Onesti ◽  
Vittorio Frasca ◽  
Marco Ceccanti ◽  
Giorgio Tartaglia ◽  
Maria Cristina Gori ◽  
...  
Keyword(s):  
Pilot Study ◽  
Myasthenia Gravis ◽  
Repetitive Nerve Stimulation ◽  
Beneficial Effects ◽  
Antibody Titers ◽  
The Stability ◽  
Ultramicronized Palmitoylethanolamide ◽  
Open Pilot

Background: The cannabinoid system may be involved in the humoral mechanisms at the neuromuscular junction. Ultramicronized-palmitoylethanolamide (μm-PEA) has recently been shown to reduce the desensitization of Acetylcholine (ACh)-evoked currents in denervated patients modifying the stability of ACh receptor (AChR) function. <p> Objective: To analyze the possible beneficial effects of μm-PEA in patients with myasthenia gravis (MG) on muscular fatigue and neurophysiological changes. <p> Method: The duration of this open pilot study, which included an intra-individual control, was three weeks. Each patient was assigned to a 1-week treatment period with μm-PEA 600 mg twice a day. A neurophysiological examination based on repetitive nerve stimulation (RNS) of the masseteric and the axillary nerves was performed, and the quantitative MG (QMG) score was calculated in 22 MG patients every week in a three-week follow-up period. AChR antibody titer was investigated to analyze a possible immunomodulatory effect of PEA in MG patients. <p> Results: PEA had a significant effect on the QMG score (p=0.03418) and on RNS of the masseteric nerve (p=0.01763), thus indicating that PEA reduces the level of disability and decremental muscle response. Antibody titers did not change significantly after treatment. <p> Conclusion: According to our observations, μm-PEA as an add-on therapy could improve muscular response to fatigue in MG. The possible modulation of AChR currents as a means of eliciting a direct effect from PEA on the conformation of ACh receptors should be investigated. The co-role of cytokines also warrants an analysis. Given the rapidity and reversibility of the response, we suppose that PEA acts directly on AChR, though further studies are needed to confirm this hypothesis.

Effectiveness of Lamotrigine in the Prophylaxis of Migraine with Aura: an Open Pilot Study

Cephalalgia ◽  
1999 ◽  
Vol 19 (1) ◽  
pp. 64-66 ◽  
Author(s):  
G D'Andrea ◽  
F Granella ◽  
M Cadaldini ◽  
GC Manzoni
Keyword(s):  
Pilot Study ◽  
Migraine With Aura ◽  
High Frequency ◽  
Controlled Trial ◽  
Open Pilot

We report a small open pilot study to evaluate the efficacy of lamotrigine (100 mg/day) in the prevention of migraine with aura attacks. We studied 24 patients affected by migraine with aura with a high frequency of attacks. Following a 1-month run-in period, the patients took lamotrigine for 3 months. Mean attack number per month was reduced from 6.1 ± 4.1 during the run-in period to 0.7 ± 1.3 at the 3rd month of treatment ( p< 0.0001). In 13 out of 21 patients who completed the study, the attacks were completely abolished at the 3rd month of treatment, while only one patient was completely unresponsive to the drug. Lamotrigine seems worthy of a controlled trial as prophylaxis of a migraine with aura.

Olanzapine Versus Haloperidol in Children With Autistic Disorder: An Open Pilot Study

2001 ◽  
Vol 40 (8) ◽  
pp. 887-894 ◽  
Author(s):  
RICHARD P. MALONE ◽  
JACQUELINE CATER ◽  
ROOMANA M. SHEIKH ◽  
MUNIYA S. CHOUDHURY ◽  
MARY ANNE DELANEY
Keyword(s):  
Pilot Study ◽  
Autistic Disorder ◽  
Open Pilot

Enteric-coated mycophenolate sodium in psoriasis vulgaris: an open pilot study

2013 ◽  
Vol 25 (1) ◽  
pp. 46-49 ◽  
Author(s):  
Shiva Fallah Arani ◽  
Rick Waalboer Spuij ◽  
Tamar Nijsten ◽  
H. A. Martino Neumann ◽  
Bing Thio
Keyword(s):  
Pilot Study ◽  
Psoriasis Vulgaris ◽  
Mycophenolate Sodium ◽  
Enteric Coated ◽  
Open Pilot
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