Immunostaining for cytokeratin 20 improves detection of micrometastatic Merkel cell carcinoma in sentinel lymph nodes

2002 ◽  
Vol 46 (5) ◽  
pp. 661-666 ◽  
Author(s):  
Lyndon D. Su ◽  
Lori Lowe ◽  
Carol R. Bradford ◽  
Alan I. Yahanda ◽  
Timothy M. Johnson ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Sentinel Lymph Nodes ◽  
Cytokeratin 20 ◽  
Merkel Cell

scholarly journals Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma

Cancer ◽  
2001 ◽  
Vol 92 (6) ◽  
pp. 1650-1655 ◽  
Author(s):  
Peter J. Allen ◽  
Klaus Busam ◽  
Arnold D. K. Hill ◽  
Alexander Stojadinovic ◽  
Daniel G. Coit
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Immunohistochemical Analysis ◽  
Sentinel Lymph Nodes ◽  
Merkel Cell

scholarly journals Detection of Merkel cell virus and correlation with histologic presence of Merkel cell carcinoma in sentinel lymph nodes

2012 ◽  
Vol 106 (7) ◽  
pp. 1314-1319 ◽  
Author(s):  
M Loyo ◽  
J Schussel ◽  
E Colantuoni ◽  
J Califano ◽  
M Brait ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Sentinel Lymph Nodes ◽  
Merkel Cell

Prognostic Significance of “Nonsolid” Microscopic Metastasis in Merkel Cell Carcinoma Sentinel Lymph Nodes

2019 ◽  
Vol 43 (7) ◽  
pp. 907-919 ◽  
Author(s):  
Emily M. Erstine ◽  
Michael T. Tetzlaff ◽  
Xuefei Jia ◽  
Phyu P. Aung ◽  
Victor G. Prieto ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Prognostic Significance ◽  
Sentinel Lymph Nodes ◽  
Merkel Cell

scholarly journals Merkel Cell Carcinoma: Recent Progress and Current Priorities on Etiology, Pathogenesis, and Clinical Management

2009 ◽  
Vol 27 (24) ◽  
pp. 4021-4026 ◽  
Author(s):  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Clinical Management ◽  
Expression Profiles ◽  
T Antigen ◽  
Neuroendocrine Cells ◽  
Human Polyomavirus ◽  
Adjuvant Radiation ◽  
Cytokeratin 20 ◽  
Merkel Cell

Purpose To expedite improved understanding, diagnosis, treatment, and prevention of Merkel cell carcinoma (MCC), a rare malignancy of cutaneous neuroendocrine cells that has a 28% 2-year mortality rate. Methods This article summarizes a workshop that discussed the state-of-the-art research and priorities for research on MCC and on a new human polyomavirus (ie, MCPyV) recently discovered in 80% of MCC tumors. Results Normal Merkel cells are widely distributed in the epidermis near the end of nerve axons and may function as mechanoreceptors or chemoreceptors. Malignant MCC cells typically stain for cytokeratin 20 as well as for other epithelial and neuroendocrine markers. MCC subtypes, which are based on histology, on cell line growth properties, and on gene expression profiles, have been reported but have not been linked to prognosis. Clinical management has been empiric. MCPyV is clonally integrated at various sites in the human genome of MCC tumors, with truncating mutations in the viral, large T antigen gene that interrupt viral replication. MCPyV seroprevalence may be high, as with previously known human polyomaviruses. MCC risk is increased 11-fold with AIDS and with other cell-mediated immune deficiencies, B-cell neoplasms, and ultraviolet radiation exposure. Conclusion Development and validation of a range quantitative polymerase chain reaction and serologic assays for detection of MCPyV, as well as an infectious clone of the virus, would clarify the fundamental biology, natural history, and epidemiology of the virus, of MCC, and of other diseases. Contingent on standardized histologic diagnosis and staging of MCC, consortia are needed to clarify the risks and benefits of sentinel lymph node biopsy, adjuvant radiation therapy, and salvage therapies; consortia are needed also for epidemiologic studies of MCC etiology.

Immunostaining for Thyroid Transcription Factor 1 and Cytokeratin 20 Aids the Distinction of Small Cell Carcinoma From Merkel Cell Carcinoma, But Not Pulmonary From Extrapulmonary Small Cell Carcinomas

2001 ◽  
Vol 125 (2) ◽  
pp. 228-231 ◽  
Author(s):  
W. Cheuk ◽  
M. Y. Kwan ◽  
Saul Suster ◽  
John K. C. Chan
Keyword(s):  
Transcription Factor ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Small Cell ◽  
Cytokeratin 20 ◽  
Merkel Cell ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Transcription Factor 1

Abstract Objective.—To study the expression of thyroid transcription factor 1 (TTF-1) and cytokeratin 20 (CK20) in pulmonary small cell carcinomas, extrapulmonary small cell carcinomas, and Merkel cell carcinomas, and thereby determine whether these markers are helpful in distinguishing these 3 groups of small cell neuroendocrine carcinomas. Materials and Methods.—Immunostaining for TTF-1 and CK20 was performed in 102 cases of small cell carcinoma (pulmonary, 52; extrapulmonary, 50) and 23 cases of Merkel cell carcinoma. The results for the 3 groups were compared. Results.—Thyroid transcription factor 1 was expressed in 82.7% of pulmonary small cell carcinomas, 42.0% of extrapulmonary small cell carcinomas (range, 33.3–53.3% for the various sites), and 0% of Merkel cell carcinomas. Cytokeratin 20 staining was consistently negative in pulmonary small cell carcinomas, and positive in 4.0% of extrapulmonary small cell carcinomas and 100% of Merkel cell carcinomas. Conclusions.—Immunostaining for TTF-1, especially when combined with immunostaining for CK20, can aid in the distinction between Merkel cell carcinoma and small cell carcinoma (both pulmonary and extrapulmonary). However, in individual cases, these markers cannot be used to distinguish between pulmonary and extrapulmonary small cell carcinomas due to the extensive overlap in immunophenotypes.

scholarly journals Comment on ‘Cytokeratin 20-negative Merkel cell carcinoma is infrequently associated with the Merkel cell polyomavirus’

2015 ◽  
Vol 29 (1) ◽  
pp. 89-90 ◽  
Author(s):  
Takeshi Iwasaki ◽  
Michiko Matsushita ◽  
Daisuke Nonaka ◽  
Ichiro Murakami ◽  
Kazuhiko Hayashi
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell Polyomavirus ◽  
Cytokeratin 20 ◽  
Merkel Cell

Differentiating Merkel cell carcinoma of lymph nodes without a detectable primary skin tumor from other metastatic neuroendocrine carcinomas: The ELECTHIP criteria

2018 ◽  
Vol 78 (5) ◽  
pp. 964-972.e3 ◽  
Author(s):  
Thibault Kervarrec ◽  
Julia Zaragoza ◽  
Pauline Gaboriaud ◽  
Amélie Le Gouge ◽  
Agnès Beby-Defaux ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Skin Tumor ◽  
Merkel Cell ◽  
Neuroendocrine Carcinomas
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