A randomized clinical trial comparing oral ondansetron with placebo in children with vomiting from acute gastroenteritis

2002 ◽  
Vol 39 (4) ◽  
pp. 397-403 ◽  
Author(s):  
Chris Ramsook ◽  
Ivonne Sahagun-Carreon ◽  
Claudia A. Kozinetz ◽  
Donna Moro-Sutherland
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Acute Gastroenteritis ◽  
Oral Ondansetron

scholarly journals Oral Versus Intramuscular Ondansetron for Reducing Vomiting in Children with Acute Gastroenteritis: A Single-Blind Randomized Clinical Trial

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Kambiz Eftekhari ◽  
Sahar Mohammadpour ◽  
Elham Shahgholi ◽  
Hosein Shabani Mirzaee ◽  
Mohsen Vigeh ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Success Rate ◽  
Randomized Clinical Trial ◽  
Drug Administration ◽  
Acute Gastroenteritis ◽  
Intramuscular Injection ◽  
High Rate ◽  
Significant Difference ◽  
Single Blind ◽  
Oral Ondansetron

Background: Acute gastroenteritis is one of the most common diseases in children with a high rate of nausea and vomiting. Drugs such as ondansetron are used to treat vomiting. Objectives: The aim of the study was to compare the success rate of oral vs intramuscular ondansetron to reduce vomiting in children with acute gastroenteritis. Methods: A single-blind randomized clinical trial study was conducted on 100 children with acute gastroenteritis. Two groups of patients were created; one group received an intramuscular injection of ondansetron and the other received oral ondansetron. The vomiting rate, hospitalization, and side effects were evaluated 30 minutes, 4, and 48 hours after drug administration. Results: Fifty-nine (59%) boys with a mean age between 3.07 ± 2.20 years were included. There were no significant differences between the groups in terms of age, weight, and rate of vomiting before the treatment was launched. No significant difference between the drug administration route and the outcome of vomiting during the first half, 4, and 48 hours after receiving the drug was found either. Conclusions: The study showed that the success rate of oral ondansetron did not vary significantly compared to intramuscular injection in terms of reducing the vomiting rate in children with acute gastroenteritis.

Randomized Clinical Trial of Rapid Versus 24-Hour Rehydration for Children With Acute Gastroenteritis

PEDIATRICS ◽  
2011 ◽  
Vol 128 (4) ◽  
pp. e771-e778 ◽  
Author(s):  
C. V. E. Powell ◽  
S. J. Priestley ◽  
S. Young ◽  
R. G. Heine
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Acute Gastroenteritis

scholarly journals Oral Ondansetron Administration to Dehydrated Children in Pakistan: A Randomized Clinical Trial

PEDIATRICS ◽  
2019 ◽  
Vol 144 (6) ◽  
pp. e20192161 ◽  
Author(s):  
Stephen B. Freedman ◽  
Sajid B. Soofi ◽  
Andrew R. Willan ◽  
Sarah Williamson-Urquhart ◽  
Emaduddin Siddiqui ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Oral Ondansetron

Randomized clinical trial of LigasureTM versus open haemorrhoidectomy

2002 ◽  
Vol 89 (2) ◽  
pp. 154-157 ◽  
Author(s):  
F. F Palazzo ◽  
D. L Francis ◽  
M. A Clifton
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial
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